ATC Abstracts

American Transplant Congress abstracts

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  • 2017 American Transplant Congress

    Anastomosis Time During Liver Transplantation Impairs Transplant Survival.

    I. Jochmans,1 S. Fieuws,2 I. Tieken,3 U. Samuel,3 J. Pirenne.1

    1Abdominal Transplantation, UZLeuven, Leuven, Belgium; 2ICBSB, KULeuven, Leuven, Belgium; 3Eurotransplant, Leiden, Netherlands

    Warm ischemia sustained during implantation might harm the liver graft.We investigated the relationship between anastomosis time (AT) and transplant survival in 5223 recipients of deceased-donor…
  • 2017 American Transplant Congress

    A Multicenter, Prospective and Randomized Trial Comparing Pancreas versus Islet Transplantation: Should We Do It Now?

    D. Cantarovich, P.-Y. Benhamou.

    ITUN, Nantes University Hospital, Nantes, France; Endocrinology, Grenoble University Hospital, Grenoble, France

    Patients suffering from type 1 diabetes are at high risk of death. Our aim is to design a multicenter, prospective and randomized study comparing pancreas…
  • 2017 American Transplant Congress

    Outcomes Following Solitary Pancreas Transplantation – Do Steroids Matter?

    C. Chan, I. Tang, J. Oberholzer, M. Campara.

    University of Illinois Hospital, Chicago

    Background: Corticosteroids remain the cornerstone of maintenance immunosuppression following pancreas transplantation but are associated with significant short- and long-term complications. Data regarding steroid sparing regimens…
  • 2017 American Transplant Congress

    Initial Experince with Total Pancreatectomy-Islet Auto-Transplantation (TP-IAT) for Chronic Pancreatitis at the University of Louisville.

    M. Hughes,1 E. Davis,1 S. Mokshagundam,2 W. Tucker,1 G. Logananthan,1 S. Williams,3 B. Appakalai.1

    1Surgery, University of Louisville, Louisville, KY; 2Medicine, University of Louisville, Louisville, KY; 3Physiology, University of Louisville, Louisville, KY

    Chronic pancreatitis (CP) represents a highly significant healthcare challenge in Kentucky. To address this need, we created a TP-IAT program to cure patients of this…
  • 2017 American Transplant Congress

    Potential Barriers Hindering Non-Directed (Altruistic) Living Kidney Donors from Donating Their Kidneys.

    A. Maghen,1 L. Kwan,1 G. Vargas,1 S. Connor,1 S. Nassiri,1 E. Hicks,2 S. Maliski,3 J. Veale.

    1Urology, David Geffen School of Medicine at UCLA, Los Angeles, CA; 2Oregon Health and Science University, Portland, OR; 3University of Kansas Medical Center School of Nursing, Kansas City, KS

    A. While non-directed kidney donation in the United States is a growing concept that demonstrates the next level of altruism in the U.S., there are…
  • 2017 American Transplant Congress

    The Transcription Factor Batf and IRF1 Controls IL-10/IL-27 Expression in Dendritic Cells and Transplant Tolerance Induction.

    G. Gu, H. Hang, Q. Xia.

    Department of Hepatic Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China

    Objective: To explore the effect of Batf and IRF1 on IL-10/IL-27 expression in DCs during transplant tolerance induction.Methods: Allogeneic heart transplants were performed between WT…
  • 2017 American Transplant Congress

    The Intragraft Vascularized Bone Marrow Component and Recipient T Regulatory Cells Facilitate Tolerance Induction After Post Transplant High Dose Cyclophosphamide Treatment in VCA.

    G. Furtmüller, B. Oh, M. Fryer, S. Ganguly, V. Malek, X. Zhou, J. Dodd-o, G. Raimondi, D. Cooney, C. Brayton, W. Lee, L. Luznik, G. Brandacher.

    Johns Hopkins University School of Medicine, Baltimore, MD

    Background: VCA is a viable treatment option for devastating tissue defects. However, the life-long need for immunosuppression curtails the wider use of VCA. Unique VCA-features…
  • 2017 American Transplant Congress

    In Depth Characterization of Ex Vivo Expanded Polyclonal Regulatory T Cells Used in a Phase I Clinical Trial Following Kidney Transplantation.

    J. Heinrichs,1 J. Mathew,1,2 I. Konieczna,1 J. He,1 X. Haung,1 A. LeFever,1 J. Leventhal.1

    1Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL; 2Microbiology and Immunology, Northwestern University, Chicago, IL

    Initial clinical trials have investigated the safety of regulatory T cells (Tregs) as a therapy during aberrant immune activation, like graft-versus-host disease (GVHD) following stem…
  • 2017 American Transplant Congress

    Enhanced Hepatic Engraftment of Stem Cell Derivatives Using Magnetic Targeting into Structurally Normal Liver.

    N. Liu, S. Fagg, J. Fair.

    Surgery, University of Texas Medical Branch, Galveston, TX

    Attaining consistent robust engraftment in the structurally normal liver is an obstacle for cellular transplantation. Until now, many therapies to increase engraftment after cellular transplantation…
  • 2017 American Transplant Congress

    Blood Gene Expression Predicts Bronchiolitis Obliterans Syndrome Appearance After Lung Transplantation.

    R. Danger,1 P. Royer,2 D. Reboulleau,2 J. Loy,2 A. Tissot,2 P. Lacoste,2 A. Roux,3 M. Reynaud-Gaubert,4 R. Kessler,5 S. Mussot,6 C. Dromer,7 O. Brugière,8 J. Mornex,9 R. Guillemain,10 M. Dahan,11 C. Knoop,12 K. Botturi,2 C. Pison,13 L. Nicod,14 S. Brouard,1 A. Magnan,2 COLT and SysCLAD Consortia.

    1CRTI UMR1064, INSERM, Université de Nantes, ITUN, CHU Nantes, Nantes, France; 2UMR_S 1087 CNRS UMR_6291, Institut du Thorax, Université de Nantes, CHU de Nantes, Nantes, France; 3CHU de Marseille, Aix Marseille Université, Marseille, France; 4CHU de Strasbourg, Strasbourg, France; 5Service de Chirurgie Thoracique, Vasculaire et Transplantation Cardiopulmonaire, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France; 6CHU de Bordeaux, Bordeaux, France; 7Service de Pneumologie et Transplantation Pulmonaire, Hôpital Bichat, Paris, France; 8Université de Lyon, INRA, UMR754, Lyon, Hospices Civils de Lyon, Lyon, France; 9Hôpital Européen George Pompidou, Paris, France; 10CHU de Toulouse, Toulouse, France; 11Hôpital Erasme, Bruxelles, Belgium; 12Clinique Universitaire Pneumologie, Pôle Thorax et Vaisseaux, CHU de Grenoble, Université de Grenoble, Inserm U1055, Grenoble, France; 13Service de Pneumologie, Centre de Transplantation, Lausanne, Switzerland

    Bronchiolitis obliterans syndrome (BOS) is the main manifestation of chronic lung allograft dysfunction responsible for the poor long-term outcome after lung transplantation. While physiopathological mechanisms…
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