Am J Transplant, Volume 17, Suppl 3 Archives - Page 181 of 181 - ATC Abstracts

2017 American Transplant Congress
Inhibition of Bruton Tyrosine Kinase Blocks Sensitization in Response to Allogeneic Skin Transplantation and Prolong Skin Graft Survival.
N. Datta, T. Palumbo, J. Kupiec-Weglinski, A. Zarrinpar.
Surgery, University of California, Los Angeles, CA
Antibody mediated rejection and donor specific antibodies are important causes of both early (hyperacute) and late (chronic) graft loss. Bruton tyrosine kinase (Btk) is required…
2017 American Transplant Congress
Recipient iNOS Deficiency Reduces Spontaneous Kidney Allograft Acceptance by Accelerating Allograft Loss.
I. Aljabban, B. Jiang, C. Yang, D. Ndishabandi, R. White, P. Russell, J. Madsen, R. Colvin, A. Alessandrini.
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA
Nitric oxide (NO) production by inducible nitric oxide synthase (iNOS), encoded by NOS2, is a hallmark of the innate immune axis, and is typically associated…
2017 American Transplant Congress
Suppression of T Cell Proliferation by CpG-Activated B Cells Depends on Granzyme-B and Cell-Cell Contact, but Not on IL-10.
L. Kojima,¹ S. Kimura,^1,2 K. Lee,¹ C. Schuetz,¹ L. Washburn,¹ K. Deng,¹ H. Tector,¹ B. Amundsen,^1,2 D. Ndishabandi,^1,2 A. Markmann,¹ M. Markmann-Porch,¹ T. Oura,¹ A. Alessandrini,^1,2 J. Kim,¹ H. Yeh,^1,2 J. Markmann.^1,2
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA; ²Transplantation Unit, Department of Surgery, Massachusetts General Hospital, Boston, MA
Background: Our previous studies document the potent capacity of regulatory B cells (Bregs) to mitigate allograft immunity. However, we have been largely unsuccessful in demonstrating…
2017 American Transplant Congress
Ex-Vivo Mitomycin-C Exposure Reduced Immunogenicity and Prolonged Survival of Islets by Suppressing the Secretion of Multiple Chemotaxis Factors.
N. Sato,¹ T. Anazawa,² A. Kenjyo,¹ T. Kimura,¹ R. Okada,¹ T. Ishigame,¹ Y. Kofunato,¹ J. Watanabe,¹ M. Muto,¹ A. Nishimagi,¹ M. Gotoh,¹ S. Marubashi.¹
¹Department of Surgery, Division of Hepato-Biliary-Pancreatic and Transplant, Fukushima Medical University, Fukushima, Japan; ²Department of Surgery, Graduate School of Midicine, Kyoto University, Kyoto, Japan
Background. Strategies to reduce immunogenicity of islets, and to prevent activation of pro-inflammatory events are essential to successful islet engraftment. We previously demonstrated that ex-vivo…
2017 American Transplant Congress
Pre-Transplant Non-Cytotoxic Donor Specific HLA Antibodies Do Not Increase the Risk of Graft Dysfunction in Kidney Transplant Recipients with Thymoglobulin and IVIG Induction.
A. Colovai, M. Ajaimi, N. Hayde, L. Kamal, S. Chan, C. Savchik, J. Rocca, E. Akalin.
Surgery, Montefiore Medical Center, Bronx, NY
The aim of this study was to evaluate the impact of pre-formed donor specific HLA antibodies (DSA) in a large population of kidney transplant (tx)…
2017 American Transplant Congress
Biopsies (Bx) of Renal Allografts with Antibody- + Cell-Mediated Rejection (ABMR/CMR) Exhibit Gene Expression Signatures from Both Types of Rejection.
H. Zhang,¹ C. Nast,² J. Doldron,² M. Cheung,² J. Mirocha,³ J. Kahwaji,¹ A. Vo,¹ S. Jordan,¹ M. Toyoda.¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles; ²Pathology, Cedars-Sinai Medical Center, Los Angeles; ³Biostatistics Center, Cedars-Sinai Medical Center, Los Angeles
Background: In HLA-sensitized kidney transplant patients (Pts) the concomitant presence of ABMR/CMR on Bx is associated with a more severe and (&) usually irreversible injury…