ATC Abstracts

American Transplant Congress abstracts

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  • 2017 American Transplant Congress

    Analysis of Differences in Living Donor and Recipient Pairs Estimated GFR at Six Months Over Time.

    D. Keith.

    Medicine, Division of Nephrology, Sacred Heart Hospital, Pensacola, FL

    Previous studies of the United States Kidney Transplant Database revealed that the median estimated GFR (eGFR) has improved over the last decade for living donor…
  • 2017 American Transplant Congress

    First Report of Human Liver Transplantation After Normothermic Machine Perfusion (NMP) in the United States.

    Q. Liu, B. Soliman, G. Iuppa, A. Nassar, A. Hassan, T. Diago Uso, K. Hashimoto, F. Aucejo, M. Fujiki, B. Eghtesad, J. Cywinski, S. Irefin, J. Fung, K. Abu-Elmagd, C. Miller, C. Quintini.

    Cleveland Clinic, Cleveland

    NMP is a novel preservation method for liver grafts. We transplanted 10 human livers after NMP to test the safety and feasibility of NMP on…
  • 2017 American Transplant Congress

    Safety and Activity of Anti-C1s Humanized Monoclonal Antibody TNT009 in Late Antibody-Mediated Kidney Allograft Rejection – Results of a First-in-Human Phase 1 Trial.

    F. Eskandary,1 B. Jilma,2 J. Muehlbacher,3 M. Wahrmann,1 H. Regele,4 N. Kozakowski,4 S. Panicker,5 J. Reeve,6 P. Halloran,6 J. Gilbert,5 G. Bohmig.1

    1Department of Medicine III, Medical University Vienna, Vienna, Austria; 2Department of Clinical Pharmacology, Medical University Vienna, Vienna, Austria; 3Department of Surgery, Medical University Vienna, Vienna, Austria; 4Department of Clinical Pathology, Medical University Vienna, Vienna, Austria; 5True North Therapeutics Inc., San Frnacisco; 6Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, Canada

    Study purpose:The classical pathway (CP) of complement may significantly contribute to antibody-mediated rejection (ABMR). Blockade of CP key component C1 may be a promising strategy…
  • 2017 American Transplant Congress

    Antibodies Specific for HLA Class I and Lung Associated Self-Antigens, Kα1Tubulin and Collagen V, Induces Exosomes Following In Vitro Binding to Human Airway Epithelial Cells.

    M. Gunasekaran, M. Sharma, S. Bansal, S. Biswas Roy, R. Walia, M. Smith, R. Bremner, T. Mohanakumar.

    Norton Thoracic Institute, St. Joseph's Hospital and Med Center, Phoenix

    Background: It is generally accepted that antibody (Ab) binding to its specific antigen, in addition to activating complement pathway, can induce intracellular signals leading to…
  • 2017 American Transplant Congress

    A Humanized Anti-CD47 Monoclonal Antibody Therapy Alleviates Ischemia-Reperfusion Injury of Porcine Renal Allografts Donated After Cardiac Death.

    M. Xu,1 B. Banan,1 X. Wang,1 D. Chirumbole,1 B. Rabe,1 S. Garcia-Aroz,1 D. Nayak,1 Z. Zhang,1 J. Jia,1 G. Upadhya,1 J. Gaut,2 P. Manning,3 Y. Lin,1 W. Chapman.1

    1Department of Surgery, Washington University School of Medicine, St. Louis; 2Department of Pathology and Immunology, Washington University School of Medicine, St. Louis; 3Tioma Therapeutics, Inc, St. Louis

    PURPOSE: This study investigated whether the blockade of the CD47 signaling pathway, which is involved in vascular endothelial nitric oxide regulation, reduces ischemia-reperfusion injury (IRI)…
  • 2017 American Transplant Congress

    Fosfomycin Tromeltamol (FOS) Is an Effective Alternative in Post Renal Transplant Urinary Tract Infection Prophylaxis Caused by Escherichia coli and Enterococcus faecalis without Increasing Resistance Rate.

    J. Arreola-Guerra,1 J. Alberu,2 L. Morales-Buenrostro,2 E. Maravilla,3 R. Rosado,3 J. Sifuentes.3

    1Nephrology and Transplantation, Centenario Hospital Miguel Hidalgo, Aguascalientes, Mexico; 2Transplantation, Instituto Nacional de Nutrición Salvador Zubirán, Mexico, Mexico; 3Medicine, Instituto Nacional de Nutrición Salvador Zubirán, Mexico, Mexico

    Urinary tract infection (UTI) is one of the most important complications in renal transplant recipients (rTR) during the first year after renal transplantation (RT). Antimicrobial…
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