Am J Transplant, Volume 17, Suppl 3 Archives - Page 181 of 181 - ATC Abstracts

2017 American Transplant Congress
Identification of NKG2D as Senescence Marker in Zero-Hour Kidney Biopsies Is Indicative for Clinical Outcome.
T. Resch,¹ J. Günther,¹ H. Hackl,² A. Sattler,³ S. Ebner,¹ P. Ritschl,³ M. Biebl,³ R. Öllinger,³ S. Schneeberger,¹ G. Brandacher,⁴ H. Schwelberger,¹ B. Zelger,⁵ D. Stauch,³ A. Pascher,³ J. Pratschke,³ K. Kotsch.³
¹Center of Operative Medicine, Department for Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, Innsbruck, Austria; ²Division of Bioinformatics, Biocenter, Medical University of Innsbruck, Innsbruck, Austria; ³Department for General, Visceral and Transplantation Surgery, Charité-Universitätsmedizin Berlin, Berlin, Germany; ⁴Department of Plastic and Reconstructive Surgery, Vascularized Composite Allotransplantation Laboratory, John Hopkins University School of Medicine, Baltimore; ⁵Institute of Pathology, Medical University of Innsbruck, Innsbruck, Austria
The definition of biological donor organ age rather than chronological age seems an obvious factor for the establishment of valid pre-transplant risk assessment. We therefore…
2017 American Transplant Congress
Kidney-Specific Immunosuppression without Adverse Systemic Effects.
D. Kentrup,¹ K. Schuette-Nuetgen,¹ H. Pawelski,¹ H. Pavenstädt,¹ S. Hermann,² M. Schaefers,² G. Larbig,³ A. Kuebelbeck,³ S. Reuter.¹
¹Department of Medicine D, University Hospital Muenster, Muenster, Germany; ²European Institute for Molecular Imaging - EIMI, University Hospital Muenster, Muenster, Germany; ³Merck KGaA, Darmstadt, Germany
Purpose: Immunosuppressive therapy is often accompanied by severe adverse effects. To overcome this, the aim of this study was the evaluation of a kidney-specific drug…
2017 American Transplant Congress
CD4 T Cell Depletion Mitigates Ischemic Hepatocellular Damage and Promotes Immune Regulation in Mouse Liver Allografts.
S. Kageyama, K. Nakamura, R. Busuttil, J. Kupiec-Weglinski, Y. Zhai.
The Dumont-UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine at University of California, Los Angeles, CA
Background: Extended cold preservation contributes to organ ischemia-reperfusion injury (IRI), which stimulates host allo-reactivity, leading to inferior clinical outcomes. We have shown that CD4+ T…
2017 American Transplant Congress
Succinate Accumulation During Warm and Cold Ischemia in Mouse, Pig and Man: Mechanistic and Therapeutic Implications for Transplant Ischemia-Reperfusion Injury.
J. Martin,^1,3 A. Costa,² A. Gruszczyk,^1,3 M. Hamed,¹ N. Georgakopoulos,¹ G. Pettigrew,¹ A. James,³ C. Frezza,² M. Murphy,³ K. Saeb-Parsy.¹
¹Department of Surgery, Cambridge, United Kingdom; ²MRC Cancer Unit, Cambridge, United Kingdom; ³MRC Mitochondrial Biology Unit, Cambridge, United Kingdom
Introduction: The burst of reactive oxygen species associated with ischemia-reperfusion (IR) injury is mediated through a specific metabolic pathway involving mitochondrial accumulation of the metabolite…
2017 American Transplant Congress
Transcriptomic Analysis Revealed a Fibrotic Role of Epithelial Cells Originated from the Recipient in Kidney Transplant.
W. Zhang,¹ Z. Yi,¹ E. Stahl,² M. Menon,¹ K. Keung,³ K. Hao,² P. O'Connell,³ B. Murphy.¹
¹Medicine, Icahn School of Medicine at Mount Sinai, New York, NY; ²Department of Genetics and Genomic Science, Ichan School of Medicine at Mount Sinai, New York, NY; ³Renal Unit, University of Sydney at Westmead Hospital, Sydney, Australia
Renal fibrosis is one of major causes for chronic renal dysfunction in kidney diseases and graft loss in kidney transplant. With an aim to better…
2017 American Transplant Congress
Highly Sensitized Patients and the Association of Early Cardiovascular Disease: Analysis of Korean Organ Transplantation Registry(KOTRY) Data.
J. Jeong,¹ J. Yang,² M. Kim,³ S. Shin,⁴ B. Chung,⁵ S. Han,⁶ C. Ahn.⁷
¹Department of Nephrology, Ajou University School of Medicine, Suwon, Korea; ²Transplantation Center, Department of Surgery, Seoul National University Hospital, Seoul, Korea; ³Department of Transplant Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea; ⁴Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; ⁵Division of Nephrology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, the Catholic University of Korea, Seoul, Korea; ⁶Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea; ⁷Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
Introduction : In recent studies, immune sensitization was associated with increased mortality in wait-listed kidney transplant candidates. We investigated whether the risk of immune sensitization…