Am J Transplant, Volume 17, Suppl 3 Archives - Page 181 of 181 - ATC Abstracts

2017 American Transplant Congress
Suppression of T Cell Proliferation by CpG-Activated B Cells Depends on Granzyme-B and Cell-Cell Contact, but Not on IL-10.
L. Kojima,¹ S. Kimura,^1,2 K. Lee,¹ C. Schuetz,¹ L. Washburn,¹ K. Deng,¹ H. Tector,¹ B. Amundsen,^1,2 D. Ndishabandi,^1,2 A. Markmann,¹ M. Markmann-Porch,¹ T. Oura,¹ A. Alessandrini,^1,2 J. Kim,¹ H. Yeh,^1,2 J. Markmann.^1,2
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA; ²Transplantation Unit, Department of Surgery, Massachusetts General Hospital, Boston, MA
Background: Our previous studies document the potent capacity of regulatory B cells (Bregs) to mitigate allograft immunity. However, we have been largely unsuccessful in demonstrating…
2017 American Transplant Congress
Ex-Vivo Mitomycin-C Exposure Reduced Immunogenicity and Prolonged Survival of Islets by Suppressing the Secretion of Multiple Chemotaxis Factors.
N. Sato,¹ T. Anazawa,² A. Kenjyo,¹ T. Kimura,¹ R. Okada,¹ T. Ishigame,¹ Y. Kofunato,¹ J. Watanabe,¹ M. Muto,¹ A. Nishimagi,¹ M. Gotoh,¹ S. Marubashi.¹
¹Department of Surgery, Division of Hepato-Biliary-Pancreatic and Transplant, Fukushima Medical University, Fukushima, Japan; ²Department of Surgery, Graduate School of Midicine, Kyoto University, Kyoto, Japan
Background. Strategies to reduce immunogenicity of islets, and to prevent activation of pro-inflammatory events are essential to successful islet engraftment. We previously demonstrated that ex-vivo…
2017 American Transplant Congress
Pre-Transplant Non-Cytotoxic Donor Specific HLA Antibodies Do Not Increase the Risk of Graft Dysfunction in Kidney Transplant Recipients with Thymoglobulin and IVIG Induction.
A. Colovai, M. Ajaimi, N. Hayde, L. Kamal, S. Chan, C. Savchik, J. Rocca, E. Akalin.
Surgery, Montefiore Medical Center, Bronx, NY
The aim of this study was to evaluate the impact of pre-formed donor specific HLA antibodies (DSA) in a large population of kidney transplant (tx)…
2017 American Transplant Congress
Biopsies (Bx) of Renal Allografts with Antibody- + Cell-Mediated Rejection (ABMR/CMR) Exhibit Gene Expression Signatures from Both Types of Rejection.
H. Zhang,¹ C. Nast,² J. Doldron,² M. Cheung,² J. Mirocha,³ J. Kahwaji,¹ A. Vo,¹ S. Jordan,¹ M. Toyoda.¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles; ²Pathology, Cedars-Sinai Medical Center, Los Angeles; ³Biostatistics Center, Cedars-Sinai Medical Center, Los Angeles
Background: In HLA-sensitized kidney transplant patients (Pts) the concomitant presence of ABMR/CMR on Bx is associated with a more severe and (&) usually irreversible injury…
2017 American Transplant Congress
Describing the Effects of the Antibiotic Regimen Immediate Post Multi-Visceral Transplant in the Pediatric Population on the Time to First Serious Bacterial Infection.
B. Chatani,¹ J. Garcia,² C. Biaggi,² T. Beduschi,³ A. Tekin,³ R. Vianna,⁴ I. Gonzalez.⁵
¹Pediatrics, Jackson Memorial Hospital, Miami, FL; ²Pediatric Gastroenterology, University of Miami Miller School of Medicine, Miami, FL; ³Miami Transplant Institute, Miami, FL; ⁴Surgery, University of Miami Miller School of Medicine, Miami, FL; ⁵Pediatric Infectious Diseases, University of Miami Miller School of Medicine, Miami, FL
This study is designed to elucidate the effect a tailored antibiotic regimen administered immediately post multi visceral transplantation may have on the duration until first…
2017 American Transplant Congress
Estrogen Receptor Alpha Mediates Female Protection from Renal Ischemia-Reperfusion Injury Through Mechanisms Extrinsic to the Kidney.
D. Aufhauser,¹ D. Murken,¹ Z. Wang,¹ G. Ge,¹ S. Concors,¹ T. Bhatti,² W. Hancock,^2,3 M. Levine.^1,4
¹Surgery, University of Pennsylvania, Philadelphia, PA; ²Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA; ³Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA; ⁴Surgery, Children's Hospital of Philadelphia, Philadelphia, PA
Introduction: Female protection from renal ischemia-reperfusion injury (IRI) is observed in both mouse and human renal transplantation. We wished to assess the role of estrogen…