ATC Abstracts

American Transplant Congress abstracts

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  • 2017 American Transplant Congress

    Human IL-10 Transfection of Porcine Lungs Significantly Increases IL-10 Levels in Vascular Perfusate During Human Blood Perfusion.

    C. Laird,1 L. Burdorf,1 X. Cheng,1 N. O'Neill,1 S. Sendil,1 D. Parsell,1 M. Cypel,2 C. Phelps,3 D. Ayares,3 A. Azimzadeh,1 R. Pierson.1

    1University of Maryland School of Medicine, Baltimore, MD; 2Department of Surgery, Toronto, Canada; 3Revivicor, Inc, Blacksburg, VA

    PurposePorcine organs are a potential source for clinical xenotransplantation. Pig lungs perfused with human blood exhibit inflammation and loss of vascular barrier function within hours.…
  • 2017 American Transplant Congress

    Focal Segmental Glomerulosclerosis Recurrence in Renal Transplant Recipients Treated with Belatacept.

    W. Kitchens, A. Farris, S. Pastan, T. Pearson, C. Larsen, A. Adams.

    Emory Transplant Center, Atlanta, GA

    Introduction: Focal segmental glomerulosclerosis (FSGS) is a cause of end-stage renal failure that frequently recurs following renal transplant, often leading to allograft loss. A recently…
  • 2017 American Transplant Congress

    Comparison of Long Term Renal Function Outcomes for Everolimus (EVR) vs. Sirolimus (SIR) vs. Mycophenolate Acid (MPA) Immunosuppressive Regimens Post Kidney Transplant (Ktx).

    H. Tedesco,1 W. Irish,2 K. Dharmesh,3 D. Patel,3 D. Cibrik.4

    1Hospital do Rim UNIFESP, Sao Paulo, Brazil; 2CTI Consulting, Raleigh; 3Novartis Pharmaceuticals Corporation, East Hanover; 4University of Michigan, Ann Arbor

    MPA or mammalian target of rapamycin inhibitors (mTORi [EVR or SIR]) in combination with calcineurin inhibitors (CNI, tacrolimus [TAC] or cyclosporine) are used for maintenance…
  • 2017 American Transplant Congress

    A Critical Analysis of Equations for MPA Exposure in Patients Under EC-MPS and Tacrolimus.

    E. David-Neto, A. Triboni, F. Ramos, F. Agena, P. Romano, G. Freitas.

    Hospital das Clinicas FMUSP, Sao Paulo, Brazil

    Mycophenolic acid(MPA) PK, from enteric-coated mycophenolate sodium(EC-MPS) has a broad range of Tmax avoiding the use a single concentration to calculate the area-under-the-time-concentration curve(AUC). Either…
  • 2017 American Transplant Congress

    Long-Term Outcomes in HIV(+) Kidney Re-Tranpslant (ReTx) Recipients vs. Primary Transplant (PrimTx) Recipients.

    G. Malat, S. Guy, K. Ranganna, D. Reich, G. Xiao, S. Talluri, M. Harhay, L. Levin Mizrahi, C. Culkin.

    Drexel University College of Medicine, Philadelphia

    Hahnemann University Hospital has performed 113 kidney transplants, including 7 ReTx. Herein we describe characteristics and allograft outcomes of HIV(+) kidney transplant recipients based on…
  • 2017 American Transplant Congress

    Association Between Matrix-gla Protein Levels and Aortic Stiffness in Kidney Transplantation.

    M. Dinic,1 N. Maillard,1 P. Delanaye,2 J.-M. Krzesinski,2 A.-M. Saint-Remy,2 E. Cavalier,3 C. Mariat.1

    1Nephrology, Dialysis and Renal Transplantation, CHU Nord, Saint Etienne, France; 2Nephrology and Dialysis, University of Liège, CHU Sart Tilman, Liège, Belgium; 3Clinical Chemistry, University of Liège, CHU Sart Tilman, Liège, Belgium

    INTRODUCTIONAortic stiffness due to vascular calcifications is commonly observed among kidney transplant recipients and is considered as a predictive factor of poor events such as…
  • 2017 American Transplant Congress

    Albuminuria in Kidney Transplant Patients Is Associated with Increased Urine Serine Proteases with the Ability to Activate ENaC.

    G. Hinrichs,1 C. Bistrup,2 H. Birn,3 B. Jensen.1

    1University of Southern Denmark, Odense, Denmark; 2Odense University Hospital, Odense, Denmark; 3Aarhus University, Aarhus, Denmark

    Background In patients with renal transplant albuminuria is associated with salt-sensitive hypertension. Aberrantly filtered serine proteases e.g. plasmin has shown to activate ENaC through proteolytic…
  • 2017 American Transplant Congress

    Pediatric Recipients of Deceased Adult Donor Kidneys Have Equivalent Outcomes Compared with Pediatric Donors.

    D. Mikhail,1 H. Sharma,3,4 J. Chen,2 M. Cooper,4 A. Sener,1,3 P. Luke.1,3

    1Urology, Western University, London, ON, Canada; 2Schulich School of Medicine and Dentistry, Western University, London, ON, Canada; 3Multi-Organ Transplant Surgery, Western University, London, ON, Canada; 4Transplant Surgery, Georgetown University, Washington, DC

    INTRODUCTION:Efforts are made to transplant paediatric deceased donor kidneys into pediatric recipients. To our knowledge, data does not support better graft outcomes with matched pediatric…
  • 2017 American Transplant Congress

    Immediate vs. Delayed Kidney Implantation Is Associated with Improved Kidney Graft Survival in Combined Liver-Kidney Transplantation.

    J. Halldorson, S. Rayhill.

    Transplant Surgery, University of California, San Diego, CA; Transplant Surgery, University of Washington, Seattle, WA

    Simultaneous Liver/Kidney transplantation involves significant potential stress for the kidney graft. A surgeon needs to decide whether to place the kidney immediately to minimize cold…
  • 2017 American Transplant Congress

    Evaluation of Renal Function After a Transition to Everolimus or Mycophenolate Mofetil in Liver Transplant Recipients.

    C. Perez,1 J. Fleming,1 M. Sell,1 B. O'brien,1 A. Rogers,1 I. Lee,1 C. Mardis,1 A. Mardis,1 N. Patel,1 H. Meadows,1 N. Pilch,2 K. Chavin,2 D. Dubay,2 R. Vinayak,2 D. Taber.2

    1Pharmacy, Medical University of South Carolina, Chareleston, SC; 2Surgery, Medical University of South Carolina, Charleston, SC

    Purpose: The aim of this study was to assess if there is a difference in renal function over time when transitioning to everolimus vs. mycophenolate.Methods:…
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