Am J Transplant, Volume 17, Suppl 3 Archives - Page 18 of 181 - ATC Abstracts

2017 American Transplant Congress
Kidney Transplant Rejection Associated with DQ Eplet Mismatches.
S. Chakola,¹ P. Warner,² N. Andeen,³ B. Najafian,³ N. Leca,¹ C. Blosser.¹
¹Medicine, University of Washington, Seattle, WA; ²Bloodworks Northwest, Seattle, WA; ³Pathology, University of Washington, Seattle, WA
The presence of anti-HLA antibodies is associated with acute rejection, allograft dysfunction and earlier graft loss. HLA antibodies are recognized as being specific to these…
2017 American Transplant Congress
A Pretransplant Model Incorporating Serum Biomarkers Is Superior to the Milan Criteria in Stratifying Risk of Hepatocellular Carcinoma Recurrence Following Liver Transplantation: Analysis of 4407 Patients from the US Multicenter HCC Transplant Consortium.
V. Agopian, On Behalf of the US Multicenter HCC Transplant Consortium.
UCLA, LA
Objective: While adoption of the Milan Criteria (MC) has improved outcomes following liver transplantation (LT) for hepatocellular carcinoma (HCC), recurrence remains a significant challenge. We…
2017 American Transplant Congress
The Ultimate Calculated Panel Reactive Antibody Value Predicts Mortality After Heart Transplantation.
E. Kransdorf,¹ M. Kittleson,¹ J. Patel,¹ M. Pando,² L. Czer,¹ J. Kobashigawa.¹
¹Cedars-Sinai Heart Institute, Los Angeles; ²Mayo Clinic Arizona, Phoenix
Background: Sensitized heart transplant (HT) candidates are known to be at higher risk for adverse events after transplantation, including a positive crossmatch, rejection, and death.…
2017 American Transplant Congress
Shared Epitopes Contribute to Accumulation of Highly Sensitized Patients in Kidney Paired Donation Program.
S. Stepkowski, B. Mierzejewska, C. Baum, D. Bekbolsynov, R. Brunner, J. Kopke, S. Rees, M. Rees.
University of Toledo, Toledo, OH
Introduction: Kidney Paired Donation (KPD) programs suffer from the accumulation of highly sensitized patients. We evaluated the sensitization patterns in our KPD program-by comparison of…
2017 American Transplant Congress
Impact of Antihypertensive (AHT) Choice and Advagraf^® Dose on Interstitial Fibrosis/Tubular Atrophy (IF/TA) and IF/TA Progression in Renal Allografts 24 Months Post-Transplantation (Tx).
S. Cockfield,¹ D. Rush,² S. Wilson,³ J. Howell,⁴ FKC-014 Study Group.
¹University of Alberta Hospital, Edmonton, AB, Canada; ²Health Sciences Centre, Winnipeg, MB, Canada; ³Astellas Pharma Global Development, Northbrook, IL; ⁴Astellas Pharma Global Development, Markham, ON, Canada
IF/TA may be delayed using ACEi- or ARB-type AHTs, which target the renin-angiotensin system (RAS), as well as by optimizing tacrolimus (TAC) exposure. The effect…
2017 American Transplant Congress
Novel Personalized Immune-Monitoring Assay for Predicting Operational Tolerance by Using Humanized Mouse Model.
Y. Fukasaku,¹ R. Goto,¹ Y. Ganchiku,¹ M. Zaitsu,¹ M. Watanabe,¹ N. Kawamura,¹ Y. Koshizuka,¹ K. Yamashita,² T. Shimamura,³ A. Taketomi.¹
¹Gastroenterological Surgery I, Hokkaido University, Sapporo, Japan; ²Transplant Surgery, Hokkaido University, Sapporo, Japan; ³Division of Organ Transplantation, Hokkaido University, Sapporo, Japan
Background: Biomarkers and immune-monitoring assays predicting operational tolerance in transplant recipients have not been established. Our aim was to develop an immune-monitoring assay to address…
2017 American Transplant Congress
Preventing of Rejection of Vascularized Composite Allografts by Targeting T Cell Metabolism.
B. Oh,¹ C. Cheng,² G. Furtmüller,¹ W. Lee,¹ J. Powell,² G. Brandacher.¹
¹Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; ²Oncology, Johns Hopkins University School of Medicine, Baltimore, MD
[Background] Upon antigen recognition and co-stimulation, T lymphocytes upregulate the metabolic machinery necessary to proliferate and sustain effector function. This metabolic reprogramming in T cells…
2017 American Transplant Congress
Unintended Consequence of the New Kidney Allocation System – Disproportionate Allocation of High Quality Kidneys to Highly Sensitized Recipients.
B. Murthy, N. Galvan, J. Moffett, C. O'Mahony, J. Goss, A. Rana.
Division of Abdominal Transplantation, Baylor College of Medicine, Houston, TX
Purpose: We hypothesize that improving access to highly sensitized candidates in new KAS would compromise the prime objective of matching the best kidney allografts and…
2017 American Transplant Congress
Short-Term Adverse Effects of Early Borderline Changes in Renal Allograft Biopsies.
S. Bhusal, P. Sood, A. Cherukuri, C. Wu, C. Puttarajappa, W. Hoffman, P. Randhawa, A. Tevar, N. Shah, S. Hariharan, R. Mehta.
Department of Medicine and Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA
Background: The short and long-term impact of borderline changes noted on renal allograft biopsies remains unclear.Methods: A total of 379 patients underwent renal transplantation at…
2017 American Transplant Congress
Does Cirrhosis Regress in HCV Liver Transplant Recipients Achieving Sustained Virologic Response in the Era of Direct-Acting Antiviral Agents?
J. Putra,¹ T. Schiano,² M. Fiel.¹
¹Pathology, Icahn School of Medicine at Mount Sinai, New York, NY; ²Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY
Background: Treatment with direct-acting antiviral agents (DAAs) in HCV patients is associated with high sustained virologic response (SVR) rates. It is hoped that cirrhosis regresses…