Am J Transplant, Volume 17, Suppl 3 Archives - Page 174 of 181 - ATC Abstracts

2017 American Transplant Congress
Banff 2013 Classification of Renal Allograft Pathology Is Superior to Banff 2007 in Detecting and Managing Milder and Earlier Cases of Antibody-Mediated Rejection.
J. Hassler,¹ V. Ariyamuthu,² A. Hendricks,¹ B. Tanriover,² J. Torrealba.¹
¹Pathology, University of Texas Southwestern Medical Center, Dallas, TX; ²Medicine, Nephrology, University of Texas Southwestern Medical Center, Dallas, TX
The 2013 Banff meeting updated the requirements for the diagnosis of acute/active antibody-mediated rejection (AAMR) in kidney allografts. There has been speculation that the changes…
2017 American Transplant Congress
Cibinetide (ARA 290), the Innate Repair Receptor Ligand, Improves Engraftment in Pancreatic Islet Transplantation by Protecting Islets and Reducing Inflammatory Reactions.
M. Watanabe,¹ M. Han Yao,¹ H. Zemack,¹ B.-G. Ericzon,¹ A. Cerami,² M. Brines,² T. Lundgren,¹ M. Kumagai-Braesch.¹
¹Department of Transplantation Surgery, CLINTEC, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; ²Araim Pharmaceuticals, Tarrytown, NY
Purpose. Cibinetide, an innate repair receptor ligand, exerts anti-inflammatory, anti-apoptotic, and cytoprotective effects. We have shown that cibinetide protected mouse pancreatic islets from cytokine-induced damage…
2017 American Transplant Congress
Outcome of ABO-Incompatible Kidney Transplantation After Stratified Desensitization.
K. Nanmoku, A. Kurosawa, T. Kubo, T. Shinzato, T. Shimizu, T. Kimura, T. Yagisawa.
Surgical Branch, Institute of Kidney Diseases, Jichi Medical University Hospital, Shimotsuke, Tochigi, Japan
Background. Plasmapheresis for antibody removal and rituximab for antibody production suppression are performed for desensitization against ABO-incompatible kidney transplantation. We evaluated clinical outcome for optimizing…
2017 American Transplant Congress
Pre-TACE Immune Status Correlates with Treatment Response and Tumor Biology in HCC as a Bridge to Transplant.
T. Sandow,¹ H. Bohorquez,² D. Kirsch,¹ A. Albar,¹ P. Thevenot,³ K. Nunez,³ D. DeVun,¹ J. Gimenez,¹ G. Galliano,⁴ A. Cohen,² G. Loss,² D. Kay,¹ P. Gulotta.¹
¹Radiology, Ochsner Clinic Foundation, New Orleans, LA; ²Transplant Surgery, Ochsner Clinic Foundation, New Orleans, LA; ³Institute of Translational Research, Ochsner Clinic Foundation, New Orleans, LA; ⁴Pathology, Ochsner Clinic Foundation, New Orleans, LA
Purpose:Immune factors are pivotal against disease progression after transplant in hepatocellular carcinoma (HCC). With chemoembolization (TACE) as a bridge to liver transplant, this study compares…
2017 American Transplant Congress
An OPO Offer Acceptance Report for Hard-to-Place Kidneys.
A. Wey, N. Salkowski, B. Kasiske, A. Israni, J. Snyder.
Scientific Registry of Transplant Recipients, Minneapolis, MN
Transplant program offer acceptance behavior varies substantially for kidneys after 100 previous offers (i.e., “hard-to-place offers”). An organ procurement organization (OPO) offer acceptance report could…
2017 American Transplant Congress
Donor Factors Show Low Impact on Patient and Kidney Allograft Outcomes: A Paired Analysis of Left/Right Deceased Donor Kidney Pairs.
T. Schachtner,^1,2,3 M. Stein,² P. Reinke.^1,2
¹Nephrology and Internal Intensive Care, Charite Campus Virchow Clinic, Berlin, Germany; ²Berlin-Brandenburg Center for Regenerative Therapies, Charite Campus Virchow Clinic, Berlin, Germany; ³Charite and Max-Delbrück Center, Berlin Institute of Health BIH, Berlin, Germany
The impact of donor factors on kidney allograft outcomes and infectious complications has been suggested in many previous studies. However, analyses of left/right donor kidney…
2017 American Transplant Congress
Plasma Extracellular Vesicles MicroRNA Signatures Associate with Graft Function Recovery Post-Acute Renal Allograft Injury.
V. Bontha, A. Fernandez-Pineros, D. Bagchi, D. Maluf, E. Rhone, V. Mas.
Surgery, UVA, Charlottesville
Background: Early host-allograft cell-to-cell communications have been reported to occur via extracellular vesicles (EVs)/protein-miRNA complexes that might determine early allograft outcomes like delayed graft function…
2017 American Transplant Congress
Blockade of Tim-3 and PD-1 Reverses Dysfunctions of Tumor Infiltrating Lymphocytes in HBV Related Hepatocellular Carcinoma.
A. Hu, F. Liu, X. Zhu, X. He.
The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
The immunosuppression of tumor infiltrating lymphocytes (TILs) is associated with rapid progress of hepatitis B virus related hepatocellular carcinoma (HBV-HCC). The inhibition molecules of T…
2017 American Transplant Congress
Neutering Worsens Liver Ischemia/Reperfusion Injury in Both Male and Female Mice.
D. Murken,¹ D. Aufhauser Jr,¹ S. Concors,¹ Z. Wang,¹ G. Ge,¹ W. Hancock,² M. Levine.¹
¹Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA; ²Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA
Introduction: Ischemia/reperfusion injury (IRI) causes significant morbidity in liver transplantation and other surgical scenarios. A better understanding of the molecular mechanisms of IRI is required…
2017 American Transplant Congress
Liver Regeneration in Porcine Hepatectomy Model.
H. Chen, D. Joo, M. Shaheen, J. Yang, S. Nyberg.
Department of Transplantation Surgery, Mayo Clinic, Rochester, MN
Background: Acute Liver Failure (ALF) is a serious condition. A substantial number of donor livers (10%) are used to save ALF patients. Supportive therapies such…