2017 American Transplant Congress
Elevated Donor HbA1C Confers Impaired Overall Survival Following Renal Allotransplantation in Recipients of Allografts from Donors with Diabetes Mellitus: A National Analysis.
Surgery, Duke University Medical Center, Durham, NC
Introduction: Donor diabetes mellitus (DM) is a risk factor for impaired outcomes following renal transplant. Donor DM is factored into the Kidney Donor Risk Index…2017 American Transplant Congress
Lymph Node Stromal Laminins Differentially Regulate T Cell Activation.
University of Maryland, Baltimore
Background:Our recent work demonstrated that laminins α4β1γ1 and α5β1γ1, components of the lymph node (LN) stroma, are differentially regulated. Tolerance is associated with relatively higher…2017 American Transplant Congress
Five Year Experience with Laparoscopic Sleeve Gastrectomy in Obese Renal Transplant Candidates.
University of Cincinnati, Cincinnati
INTRODUCTION: Obesity in end stage renal disease (ESRD) patients may not be adequately addressed by medical management, and represents a barrier to renal transplantation. We…2017 American Transplant Congress
CTLA4Ig Suppresses Memory Responses to HLA-A2+ Skin Grafts in a Mouse Model of Allosensitization by Reducing CD138+ Plasma Cells.
Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
Purpose: In previous studies we demonstrated that CTLA4Ig suppresses de novo T-cell activation through blocking CD28 co-stimulation and attenuates recall alloantibody responses following re-exposure to…2017 American Transplant Congress
Geographic Disparities in Access to Deceased Donor Kidney Transplant.
In 2015, SRTR was asked by HRSA to investigate geographic disparities in access to deceased donor kidney transplant. To account for the potential impact of…2017 American Transplant Congress
The Impact of Delayed Graft Function on Long Term Graft Survival Adjusted for Donor Kidney Quality Assessed by the KDPI.
Nephrology Charite Campus Mitte, Charite Universitaetsmedizin Berlin, Berlin, Germany
IntroductionDelayed graft function (DGF) is associated with impaired graft survival in kidney transplant recipients. The kidney donor profile index (KDPI) is increasingly evaluated as a…2017 American Transplant Congress
Determinants of Severe Interstitial Fibrosis in Kidney Allografts: Major Impact of Circulating Donor-Specific Anti-HLA Antibodies.
Paris Translational Research Center for Organ Transplantation, Paris, France
Interstitial fibrosis represents a major cause of kidney allograft failure. We investigated the independent contribution of circulating donor-specific anti-HLA antibodies (DSA) in the development of…2017 American Transplant Congress
Donor-Derived Nonclassical Monocytes Produce MIP-2 to Recruit Recipient Neutrophils and Cause Ischemia Reperfusion Injury After Lung Transplant.
1Northwestern University, Chicago; 2Washington University, St Louis
Purpose: Primary graft dysfunction (PGD), the primary cause of early mortality after lung transplant, is mediated by neutrophils. However, neutrophil depletion may not be clinically…2017 American Transplant Congress
Blood and Biopsy Genomic Signatures of Acute Rejection in Liver Transplant Recipients.
Background: Biomarker profiles diagnostic of acute rejection (AR) could enhance the diagnosis and management of liver transplant (LT) recipients. Our aim was to identify diagnostic…2017 American Transplant Congress
Complement Binding Activity (C3d, C1q) of De Novo Donor-Specific HLA Antibody Is Associated with Increased Risk of Antibody-Mediated Rejection in Non-Sensitized Kidney Transplant Recipients.
Despite advances in therapeutic strategies and medicine, antibody mediated rejection (AMR) is a leading cause of kidney graft loss. The complement binding activity of donor-specific…
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