Am J Transplant, Volume 17, Suppl 3 Archives - Page 173 of 181 - ATC Abstracts

2017 American Transplant Congress
Donor Recipient Matching Based on HLA Epitopes Improves Outcome in Kidney Transplant Recipients.
O. Staeck,¹ M. Niemann,³ F. Halleck,¹ D. Khadzhynov,¹ C. Schönemann,² P. Reinke,¹ E. Spierings,⁴ K. Budde,¹ N. Lachmann.²
¹Nephrology, Charité Universitaetsmedizin, Berlin, Germany; ²HLA Laboratory, Charité Universitaetsmedizin, Berlin, Germany; ³PIRCHE, Berlin, Germany; ⁴Laboratory of Translational Immunology, UMC Utrecht, Utrecht, Netherlands
Background: HLA mismatches of the donor and recipient causing de novo donor-specific HLA antibodies (dnDSA) are a risk factor for immunologic complications and poor graft…
2017 American Transplant Congress
Gut Microbial Metabolite Improves Function and Prolongs Kidney Allograft Survival in Mice.
H. Wu,^1,2 T. Kwan,¹ Y. Loh,¹ X. Chen,¹ L. Macia,^2,3 S. Alexander,^2,4 S. Chadban.^1,2
¹Kidney Node Laboratory, The Charles Perkins Centre and Renal Medicine, Sydney Medical School and Royal Prince Alfred Hospital, Sydney, Australia; ²University of Sydney, Sydney, Australia; ³Nutritional Immunometabolism Lab, The Charles Perkins Centre, Sydney Medical School, Sydney, Australia; ⁴Nephrology Department, The Children Hospital at Westmead, Sydney, Australia
To determine the impact of dietary administration of the gut microbial metabolite sodium acetate (SA) on kidney rejection and survival in a fully MHC-mismatched murine…
2017 American Transplant Congress
Effect of Preformed Donor-Specific Antibodies in Intestine/Multivisceral Transplantation.
M. Safwan,¹ M. Rizzari,¹ K. Collins,¹ A. Yoshida,¹ S. Skorupski,² O. Fagoaga,² M. Abouljoud,¹ S. Nagai.¹
¹Divison of Transplant and Hepatobiliary Surgery, Henry Ford Transplant Institute, Detroit, MI; ²Transplant Immunology, Henry Ford Hospital, Detroit, MI
Aim: To analyze the effect of preformed donor-specific antibodies (DSA) in intestine/multivisceral transplantation patients.Methods: Retrospective review of preformed and de novo DSAs of all intestine/multivisceral…
2017 American Transplant Congress
CD28 Directed Immunotherapy Is More Potent Than Belatacept in a Nonhuman Primate Xenotransplant Model.
S. Kim,¹ L. Higginbotham,¹ D. Mathews,¹ C. Breeden,¹ A. Stephenson,¹ C. Larsen,¹ M. Ford,¹ J. Tector,² A. Adams.¹
¹Emory Transplant Center, Emory University, Atlanta, GA; ²University of Alabama Birmingham, Birmingham, AL
Introduction. Xenotransplantation may alleviate the organ shortage, yet experimental renal xenotransplantation has met limited success. T cell-mediated damage remains a critical problem. Our group has…
2017 American Transplant Congress
How to Improve Pre-Kidney Transplant Education for Hispanics: Preferences and Perceptions of Northwestern Memorial Hospital's Hispanic Transplant Program.
H. Gomez, E. Malagon-Blackwell, J. Caicedo.
The Comprehensive Transplantation Center, Northwestern University Feinberg School of Medicine, Chicago, IL
Context: Pre-Transplant educational sessions improve access to transplantation. Currently, however, there is lack of culturally competent approaches to improve living kidney donation for Hispanics Americans.…
2017 American Transplant Congress
Long-Term Drug-Free Survival of Tiny Cynomolgus Islet Allografts.
M. Koulmanda, V. Chipashivili, M. Duggan, T. Strom.
Surgery and Medicine, Beth Israel Deaconess Medical Center, Boston, MA; Surgery, Massachusetts General Hospital, Boston, MA
Following upon highly beneficial effects observed with short-term alpha 1-antitrypsin (AAT) treatment in the marginally sized autologous cynomolgus islet transplant model, we are testing the…
2017 American Transplant Congress
The Combined Effects of Induction Regimens and Antiviral Prophylaxis on the Risk of CMV Infection in Different Serostatus Subgroups After Liver Transplantation.
C. Low,² S. Hosseini-Moghaddam,^1,2 C. Rotstein,² E. Renner,² A. Humar,² D. Kumar,² S. Husain.²
¹Medicine, Western University, London Health Sciences Centre, London, Canada; ²University Health Network, Toronto, Canada
Introduction: Simultaneous effects of anti-CMV prophylaxis and induction regimens on cytomegalovirus (CMV) infection after liver transplantation (LTRs) have not been studied. We determined the magnitude…
2017 American Transplant Congress
TRPV4 Channels Mediate Pulmonary Edema and Inflammation During Ischemia-Reperfusion Injury.
E. Charles, Y. Zhao, K. Hong, C. Marziano, J. Mehaffey, I. Kron, S. Sonkusare, V. Laubach, A. Sharma.
University of Virginia, Charlottesville, VA
Rationale: Lung ischemia-reperfusion (IR) injury remains a major challenge in post-transplant patients. Transient receptor potential vanilloid 4 (TRPV4) cation channels mediate cellular calcium influx, and…
2017 American Transplant Congress
Phase 3 Trial of Transplantation of Human Islets in Type 1 Diabetes (T1D) Post Renal Transplantation.
J. Markmann, R. Alejandro, M. Bellin, N. Bridges, W. Clarke, T. Eggerman, E. Foster, B. Hering, D. Kaufman, O. Korsgren, X. Luo, A. Naji, J. Oberholzer, A. Posselt, M. Rickels, C. Ricordi, M. Robien, P. Senior, A. Shapiro, N. Turgeon.
CIT Consortium
Introduction: From a risk-benefit perspective, patients with type 1 diabetes (T1D) who are already obligated to long-term immunosuppression to support a kidney transplant and who…
2017 American Transplant Congress
Chronic Antibody Mediated Rejection (cABMR) in ABO-Incompatible and ABO-Compatible Kidney Transplants: A Single US Center Experience.
S. Sethi, A. Vo, E. Huang, L. Varanasi, J. Choi, A. Peng, R. Najjar, S. Jordan.
Comprehensive Transplant Center, Cedars Sinai Medical Center, Los Angeles, CA
Introduction:Similar patient and graft outcomes have been previously reported for ABO compatible (ABOc) and ABO incompatible (ABOi) kidney transplants. However, data are limited on the…