Am J Transplant, Volume 17, Suppl 3 Archives - Page 171 of 181 - ATC Abstracts

2017 American Transplant Congress
Geographic Disparity in Kidney Transplantation After KAS.
S. Zhou,¹ A. Massie,¹ X. Luo,¹ E. Chow,¹ S. Bae,¹ S. Gentry,² S. Gustafson,³ A. Wey,³ B. Thompson,³ N. Salkowski,³ J. Snyder,³ D. Segev.¹
¹JHU, Baltimore; ²USNA, Annapolis; ³CDRG, Minneapolis
The Kidney Allocation System (KAS), implemented in 12/2014, increased regional and national sharing of kidneys. Ideally, broader sharing would also reduce some of the stark…
2017 American Transplant Congress
The Innate Immune-System May Play an Enhanced Role in Acute Cellular Rejection in Patients on Belatacept-Based Immunosuppression.
D. Dobi,¹ Q. Tang,² S. Chandran,³ F. Vincenti,³ Z. Laszik.¹
¹Department of Pathology, University of California, San Francisco, San Francisco, CA; ²Department of Surgery, Division of Transplant Surgery, University of California, San Francisco, San Francisco, CA; ³Department of Medicine, Division of Nephrology, University of California, San Francisco, San Francisco, CA
Purpose. The incidence of acute cellular rejection (ACR) in kidney transplant patients on Belatacept (Bela-ACR) is higher than in those with CNI-based regimens (CNI-ACR). However,…
2017 American Transplant Congress
Antibody Mapping by Protein Microarray Revealed a Unique Repertoire in Lung Transplant Recipients That Developed Chronic Lung Allograft Dysfunction.
D. Nayak,¹ K. Garcia,² P. Pirrotte,² R. Hachem,³ R. Bremner,¹ M. Smith,¹ T. Mohanakumar.¹
¹Norton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ; ²Translational Genomics Research Institute, Phoenix, AZ; ³Washington University, St. Louis, MO
Background: Development of chronic lung allograft dysfunction (CLAD) limits long-term success from lung transplantation (LTx). Elicitation of de novo antibody (Ab) to mismatched donor HLA…
2017 American Transplant Congress
Multiple Dosing of Anti-C1s Antibody TNT009 – Effect on HLA Antibody-Triggered Complement Activation in Healthy Volunteers and Kidney Transplant Recipients with Antibody-Mediated Rejection.
J. Muhlbacher,¹ B. Jilma,² M. Wahrmann,³ F. Eskandary,³ J. Gilbert,⁴ S. Panicker,⁴ G. Böhmig.³
¹Department of Surgery, Medical University Vienna, Vienna, Austria; ²Department of Clinical Pharmacology, Medical University Vienna, Vienna, Austria; ³Department of Medicine III, Medical University Vienna, Vienna, Austria; ⁴True North Therapeutics, Inc., San Francisco, CA
Study purpose. Complement inhibition may be an attractive strategy to prevent antibody-mediated allograft injury. One promising therapeutic target may be the enzymatic activity of key…
2017 American Transplant Congress
2B4-Mediated Inhibition of Proliferation and Glycolytic Function Attenuates T Cell Alloreactivity.
S. Laurie, D. Liu, M. Cortes, M. Wagener, M. Ford.
Emory Transplant Center, Atlanta, GA
Current thinking holds that costimulation-blockade resistant graft rejection may be mediated by CD28null T cells. To further investigate this possibility, we performed a retrospective immunophenotypic…
2017 American Transplant Congress
Applicability and Safety of a Regulatory T Cell Therapy in Adult Liver Transplantation: The “ThRIL” Phase I First-in-Human Trial.
G. Whitehouse, N. Safinia, S. Thirkell, L. Fry, N. Grageda, M. Martinez-Llordella, R. Lechler, N. Heaton, G. Lombardi, A. Sanchez-Fueyo.
MRC Centre for Transplantation, King's College London, London, United Kingdom
Aim“ThRIL” is a multiple site, open-label, uncontrolled, phase I clinical trial assessing the safety and applicability of a CD4+CD25+FOXP3+ regulatory T cell (Treg) immunotherapy in…
2017 American Transplant Congress
Kidney Injury Molecule-1 Mitigates Tissue Damage from Transplant Renal Ischemia Reperfusion Injury.
J. Lee,^1,2 X. Zhang,² A. Haig,³ D. Lian,² P. Anderson,² R. Navaratnam,² L. Gunaratnam.^1,2
¹Department of Microbiology and Immunology, Western University, London, ON, Canada; ²Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, ON, Canada; ³Department of Pathology, Western University, London, ON, Canada
Ischemia reperfusion injury (IRI) at the time of organ harvesting is unavoidable, may cause delayed renal graft function, and is associated with premature graft loss.…
2017 American Transplant Congress
Chagas Disease and Outcome in Kidney Transplant.
M. Taylor, A. Martinoia, S. Di PIetrantonio, M. Torres, H. Petrone.
Renal Transplant Unit, CRAI Sur - CUCAIBA, La Plata, Buenos Aires, Argentina
Introduction: Chagas disease is one of the most expanded endemic in Latin America with 8 people from every 10.000.000 being infected. In Argentina its estimated…
2017 American Transplant Congress
Contemporary Outcomes and Risk Factors of Acute Graft-versus-Host Disease After Liver Transplant.
J. Markus, A. Bukannan, B. Kashat, R. Salgia.
Gastroenterology and Hepatology, Henry Ford Hospital, Detroit, MI
Introduction:Acute graft-versus-host-disease (GVHD) is a rare complication of orthotopic liver transplant (LT) that has an estimated incidence of 0.1%-2% per year. This complication of OLT…
2017 American Transplant Congress
Epigenetic Modifications in the Progression to Chronic Renal Allograft Injury.
V. Bontha,¹ D. Maluf,¹ M. Dozmorov,² K. Archer,³ L. Gallon,⁴ V. Mas.¹
¹UVA, Charlottesville; ²VCU, Richmond; ³OSU, Columbus; ⁴NWU, Chicago
Background: The renal allograft is exposed to a milieu of environmental/metabolic stimuli that trigger epigenetic modifications and thereby gene expression patterns which influence function and…