2017 American Transplant Congress
Necroptotic Cellular Death Modulates TNFα Mediated Inflammation and Cardiac Allograft Rejection in Mice.
Immunology Institute, Icahn School of Medicine at Mount Sinai, NYC, NY
While graft injury following cold ischemia reperfusion (IR) can accelerate graft rejection, mechanisms are incompletely understood. Evidence indicates that posttransplant IR injury is associated with…2017 American Transplant Congress
A Search for a Biomarker Which Predicts Belatacept-Resistant Rejection.
Belatacept, an inhibitor of the CD28-CD80/86 costimulatory pathway, has been associated with a higher acute rejection risk than ciclosporin. We sought to identify a biomarker…2017 American Transplant Congress
Assessment of Attitudes Toward Use of Hepatitis C Positive Liver Allografts in US Transplant Centers.
Background:Direct-acting antivirals (DAAs) have been shown to have high cure rates in hepatitis C (HCV)-positive liver transplantation (LT) recipients. The organ donor shortage has led…2017 American Transplant Congress
Knowledge and Attitudes Associated with Willingness to Accept HIV+ Organs Among Persons Living with HIV.
Surgery, Johns Hopkins, Baltimore
HIV-to-HIV organ transplants are a novel treatment for organ failure in HIV-positive (HIV+) individuals. However, attitudes of potential HIV+ recipients regarding HIV+ donors remain unknown.Methods:…2017 American Transplant Congress
Ectopic Lymphoid Structures Are Present in Type I T-Cell Mediated Kidney Transplant Rejection.
BackgroundIn renal transplantation, many allograft recipients develop donor-specific antibodies associated with an increased risk for graft rejection. Current immunosuppressive agents are principally aimed at T-cell-mediated…2017 American Transplant Congress
Relationship Between Mixed Chimerism and Tolerance in HLA-Matched and -Mismatched Recipients of Kidney and Hematopoietic Cell Transplants.
Twenty-eight fully HLA-matched and 18 HLA haplotype- matched recipients were given combined kidney and hematopoietic cell transplants using a completely post-transplant conditioning regimen consisting of…2017 American Transplant Congress
A Proof of Concept for Liver Graft Modification Using Warm Ex Vivo Perfusion – “It Is Not Just About Rescuing Marginal Grafts”.
Toronto General Hospital, University of Toronto, Toronto, Canada
Background: The active metabolism during normothermic ex vivo liver perfusion (NEVLP) offers a new opportunity to use the preservation time for graft modification and repair…2017 American Transplant Congress
Mutations in Influenza A Virus and Clinical Implications in Transplant Recipients.
1UHN, Toronto, Canada; 2REIPI, Seville, Spain; 3UPenn, Philadelphia; 4LUMC, Leiden, Netherlands
Background: Organ and hematopoietic stem cell transplant (HSCT) recipients are predisposed to complications of influenza infection and as such may constitute an important source of…2017 American Transplant Congress
Prescription Opioid Use Before and After Kidney Transplant: Implications for Post-Transplant Outcomes.
We previously identified associations of opioid use before kidney transplant (KTx) with post-KTx complications.To confirm and extend these findings, we examined a novel database wherein…2017 American Transplant Congress
Analysis of Differences in Living Donor and Recipient Pairs Estimated GFR at Six Months Over Time.
Medicine, Division of Nephrology, Sacred Heart Hospital, Pensacola, FL
Previous studies of the United States Kidney Transplant Database revealed that the median estimated GFR (eGFR) has improved over the last decade for living donor…
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