Am J Transplant, Volume 17, Suppl 3 Archives - Page 17 of 181 - ATC Abstracts

2017 American Transplant Congress
Preventing of Rejection of Vascularized Composite Allografts by Targeting T Cell Metabolism.
B. Oh,¹ C. Cheng,² G. Furtmüller,¹ W. Lee,¹ J. Powell,² G. Brandacher.¹
¹Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; ²Oncology, Johns Hopkins University School of Medicine, Baltimore, MD
[Background] Upon antigen recognition and co-stimulation, T lymphocytes upregulate the metabolic machinery necessary to proliferate and sustain effector function. This metabolic reprogramming in T cells…
2017 American Transplant Congress
Unintended Consequence of the New Kidney Allocation System – Disproportionate Allocation of High Quality Kidneys to Highly Sensitized Recipients.
B. Murthy, N. Galvan, J. Moffett, C. O'Mahony, J. Goss, A. Rana.
Division of Abdominal Transplantation, Baylor College of Medicine, Houston, TX
Purpose: We hypothesize that improving access to highly sensitized candidates in new KAS would compromise the prime objective of matching the best kidney allografts and…
2017 American Transplant Congress
Short-Term Adverse Effects of Early Borderline Changes in Renal Allograft Biopsies.
S. Bhusal, P. Sood, A. Cherukuri, C. Wu, C. Puttarajappa, W. Hoffman, P. Randhawa, A. Tevar, N. Shah, S. Hariharan, R. Mehta.
Department of Medicine and Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA
Background: The short and long-term impact of borderline changes noted on renal allograft biopsies remains unclear.Methods: A total of 379 patients underwent renal transplantation at…
2017 American Transplant Congress
Does Cirrhosis Regress in HCV Liver Transplant Recipients Achieving Sustained Virologic Response in the Era of Direct-Acting Antiviral Agents?
J. Putra,¹ T. Schiano,² M. Fiel.¹
¹Pathology, Icahn School of Medicine at Mount Sinai, New York, NY; ²Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY
Background: Treatment with direct-acting antiviral agents (DAAs) in HCV patients is associated with high sustained virologic response (SVR) rates. It is hoped that cirrhosis regresses…
2017 American Transplant Congress
Experience with the Bacterial Enzyme IdeS (IgG Endopeptidase) for Desensitization of Highly-HLA Sensitized (HS) Kidney Allograft Recipients.
S. Jordan,¹ J. Choi,¹ C. Kjellman,² L. Winstedt,² X. Zhang,⁴ S. Louie,¹ A. Kang,¹ M. Haas,³ A. Vo.¹
¹Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA; ²Hansa Medical, Lund, Sweden; ³Dept of Pathology, Cedars-Sinai Medical Center, Los Angeles, CA; ⁴HLA, Cedars-Sinai Medical Center, Los Angeles, CA
Donor specific antibodies (DSA) create an impenetrable immunologic barrier to transplantation. Current rx aimed at modification of DSAs are not effective in the most HS…
2017 American Transplant Congress
Tracking the In Vitro Phenotype and Proliferative Capacity of CD57+ CD4 T Cells.
J. Espinosa,¹ J. Lockley,¹ F. Shaw,¹ R. Osborne,¹ M. Joshi,¹ T. Woody,¹ M. Ellis,¹ B. Hollister,¹ J. Cheeseman,¹ R. Townsend,² A. Kirk.¹
¹Duke University, Durham; ²Bristol-Meyers Squibb, Princeton
CD57+PD1- CD4 T cells are primed effectors with increased expression of adhesion molecules capable of infiltrating allografts and mediating belatacept-resistant rejection (BRR). Whether CD57 is…
2017 American Transplant Congress
Dominant Role of Clonal Deletion in Achieving Immune Tolerance After Unrelated Cord Blood Transplantation.
P. Szabolcs,^1,2 X. Chen,¹ M. Hill.¹
¹BMT and Cell Therapy, Children Hospital of Pittsburgh UPMC, Pittsburgh, PA; ²Immunology, University of Pittsburgh, Pittsburgh, PA
The mechanism of immune tolerance after successful hematopoietic stem cell transplantation is not fully understood. Both central (clonal deletion) and peripheral (anergy, Treg, Tr1) mechanisms…
2017 American Transplant Congress
Expression of Injury and Repair Genes in Ex Vivo Perfused Swing Lung Transplants.
P. Dromparis,¹ S. Wagner,¹ N. Aboelnaz,² J. Luc,² D. Freed,² J. Nagendran,² M. Mengel,¹ B. Adam.¹
¹Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada; ²Surgery (Cardiac Surgery), University of Alberta, Edmonton, Canada
Due to acute lung injury (ALI), only 20% of donated lungs are suitable for transplant and of those, 25% develop primary graft dysfunction. Ex vivo…
2017 American Transplant Congress
Hepatitis E Virus-Associated Cryoglobulinemia in Solid-Organ-Transplant Recipients: A Prospective Study.
O. Marion,¹ F. Abravanel,² L. Esposito,¹ S. Lhomme,² A. Del Bello,¹ J. Izopet,² N. Kamar.¹
¹Nephrology and Organ Transplant Unit, CHU Rangueil, Toulouse, France; ²Laboratory of Virology, CHU Purpan, Toulouse, France
Hepatitis E virus (HEV) is responsible for acute and chronic autochthonous hepatitis in developed countries, particularly in Western Europe. Conversely to hepatitis B or C,…
2017 American Transplant Congress
Factors Predicting 30-Day Hospital Readmission After Kidney Transplant.
J. Ostrem, M. Brokhof, N. Kenyon, E. Hollinger, S. Jensik, O. Olaitan, M. Hertl, N. Alvey.
Rush University Medical Center, Chicago, IL
Background: Hospital readmissions after kidney transplant have been associated with increased morbidity, mortality, decreased quality of life, and increased healthcare costs. The objective of this…