Am J Transplant, Volume 17, Suppl 3 Archives - Page 16 of 181 - ATC Abstracts

2017 American Transplant Congress
Combining Neural Stem Cell Transplantation with Mixed Hematopoietic Chimerism Promotes Restoration of Self-Tolerance in Established Experimental Autoimmune Encephalomyelitis.
W. Orent, J. Marino, B. Gonzalez Nolasco, J. Paster, A. Harney, D. Sachs, G. Benichou.
Surgery, Massachusetts General Hospital, Boston, MA
Multilineage mixed hematopoietic chimerism induces tolerance to alloantigens in rodents, large animals and kidney-transplanted patients. Here we combined mixed chimerism with neural stem cell (NSC)…
2017 American Transplant Congress
Human Islet-Derived Extracellular Vesicles Stimulate CD14+ Monocytes Resulting in Proinflammatory Cytokine Production.
A. Rutman, S. Negi, C. Hasilo, M. Gasparrini, J. Tchervenkov, S. Paraskevas.
Department of Surgery, McGill University Health Centre, Montreal, QC, Canada
Introduction: The cellular events involved in the generation of an auto and allo-reactive immune response in recipients of islet transplantation are not well understood. In…
2017 American Transplant Congress
Outcome of Living-Donor Kidney Transplantation in Cross-Match-Positive Recipients at a Single Center.
D. Okada,¹ M. Okumi,¹ K. Unagami,² T. Shimizu,¹ H. Ishida,¹ K. Tanabe.¹
¹Urology, Tokyo Women's Medical University, Tokyo, Japan; ²Nephrology, Tokyo Women's Medical University, Tokyo, Japan
BackgroundLiving-donor kidney transplantation in cross-match (XM)-positive patients remains high-risk and requires an optimal desensitization protocol. We started a desensitization protocol for XM-positive patients in January…
2017 American Transplant Congress
Predicting Recurrence Prior to Transplant: The Response of HCC to Chemoembolization.
T. Sandow,¹ H. Bohorquez,² D. Kirsch,¹ P. Thevenot,³ K. Nunez,³ A. Albar,¹ D. DeVun,¹ J. Gimenez,¹ G. Galliano,⁴ A. Cohen,² G. Loss,² D. Kay,¹ P. Gulotta.¹
¹Radiology, Ochsner Clinic Foundation, New Orleans, LA; ²Transplant Surgery, Ochsner Clinic Foundation, New Orleans, LA; ³Institute of Translational Research, Ochsner Clinic Foundation, New Orleans, LA; ⁴Pathology, Ochsner Clinic Foundation, New Orleans, LA
Purpose:This study assesses imaging response characteristics of patients with hepatocellular carcinoma (HCC) to chemoembolization (TACE) as a bridge to transplant and the risk of post-transplant…
2017 American Transplant Congress
A Multistate Modeling Analysis of Time-Varying CPRA States and Its Impact on Kidney Transplant: A Focus on KAS Implementation.
S. Kulkarni,¹ I. Hall,² R. Formica,¹ D. Stewart,³ E. Greene,⁴ Y. Deng.⁴
¹Surgery & Medicine, Yale School of Medicine, New Haven, CT; ²Medicine, Utah School of Medicine, Salt Lake City, UT; ³United Network of Organ Sharing, Richmond, VA; ⁴Center for Analytical Sciences, Yale School of Public Health, New Haven, CT
Background: Highly sensitized kidney transplant candidates are at higher risk of death on the waiting list(WL). OPTN policy change 8(Kidney Allocation System(KAS)) aimed to improve…
2017 American Transplant Congress
Short- and Long-Term Graft Survival After Kidney Transplantation in Western Europe.
M. Coemans,¹ G. Verbeke, D. Anglicheau, O. Bestard, M. Giral, M. Naesens.^1,2
¹Microbiology and Immunology, KU Leuven, Leuven, Belgium; ²Nephrology and Renal Transplantation, KU Leuven, Leuven, Belgium
Background: Improvement of kidney survival after transplantation has mainly been studied in the American population. There, it was found that improvement mostly occurred on the…
2017 American Transplant Congress
Post-Transplant Urinary Transglutaminase 2 Is a Potent Biomarker to Predict Kidney Allograft Inflammation or Fibrosis.
S. Shin,¹ Y.-M. Wee,¹ M. Choi,¹ Y. Cho,² H. Go,² Y. Kim,¹ D. Han.¹
¹Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; ²Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
Transglutaminase type 2 (TG2) is an extracellular matrix crosslinking enzyme with a pivotal role in kidney fibrosis. We tested the hypothesis that quantification of urinary…
2017 American Transplant Congress
Differential Effects of Immunosuppressive Drugs on DNA Methylation in T Cells.
F. Peters,¹ A. Peeters,¹ L. Hofland,² M. Betjes,¹ K. Boer,¹ C. Baan.¹
¹Nephrology and Transplantation, Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands; ²Endocrinology, Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands
Introduction The immune response after transplantation can be affected by DNA methylation – an epigenetic modification that regulates gene expression, including that of immune-related genes.…
2017 American Transplant Congress
Direct Intrahepatic Delivery of Pegylated-Catalase Is Protective in a Rat Ischemia-Reperfusion Injury Model.
E. Beal,¹ S. Black,¹ J. Kim,¹ V. Velazquez,² K. Washburn,¹ D. Hayes Jr.,³ B. Whitson.¹
¹Department of Surgery, Division of Transplant, The Ohio State University Wexner Medical Center, Columbus, OH; ²Center for Vaccines and Immunity, The Research Institute at Nationwide Childrens Hospital, Columbus, OH; ³Departments of Pediatrics and Internal Medicine, The Ohio State University College of Medicine, Columbus, OH
Introduction: Ischemia-reperfusion injury (IRI) is characterized by cessation of blood flow to an organ or tissue leading to accumulation of toxic metabolites and free radicals,…
2017 American Transplant Congress
Results of Stem Cell and Renal Transplantation in Patients with End Stage Renal Disease After Plasma Cell Dyscrasias.
C. Moliz,¹ B. Redondo,¹ M. Molina,¹ E. Morales,¹ E. Gonzalez,¹ J. Cabrera,² A. Andres.¹
¹Nephrology Department, Hospital Universitario 12 de Octubre, Madrid, Spain; ²Nephrology Department, Hospital Evangelico y Hospital Militar, Montevideo, Uruguay
Introduction: Plasma cell dyscrasias (PCD) are a cause of end stage renal disease (ESRD). Traditionally, renal transplantation (RT) has been avoided in these patients due…