2017 American Transplant Congress
Utility of Weighted Composite Endpoints in Kidney Transplantation.
Cleveland Clinic, Cleveland, OH
IntroductionAdvances in therapeutic development and innovation are stifled in transplantation based on difficulties demonstrating efficacy of novel interventions using standard endpoints. Current RCTs are constrained…2017 American Transplant Congress
Identifying the Specific Causes and the Determinants of Outcome in Kidney Recipients with Transplant Glomerulopathy: A Multicenter Study.
BackgroundUnderstanding the specific causes of TG and its long-term consequences at population scale is lacking.MethodsThis study includes all kidney allograft biopsies performed between 2004 and…2017 American Transplant Congress
Center-Level Differences in Outcomes Following High-KDPI Kidney Transplants.
The SRTR reports regularly about center-level differences in graft failure after deceased donor kidney transplantation (DDKT). While these models are adjusted, they provide only information…2017 American Transplant Congress
Glucocorticoid Receptor – Relaxin Signaling in Liver Transplant Ischemia-Reperfusion Injury (IRI): From Bench-to-Bedside.
Background: Glucocorticoid receptor (GR) serves as a receptor for relaxin (RLX), a pregnancy hormone, with novel vasoactive and tissue remodeling properties. A phase III clinical…2017 American Transplant Congress
Costimulation Independent Acute Rejection Requires CD127 Signaling.
Department of Surgery, Emory University, Atlanta, GA
Clinical costimulation blockade with belatacept leads to improved survival and graft function. However, a subset of patients experience costimulation independent rejection. We identified a critical…2017 American Transplant Congress
Steroid Withdrawal and De Novo Donor-Specific HLA Antibodies in Renal Transplant Patients: A Prospective, Randomized, Controlled Study in Parallel Groups. Preliminary Results.
Introduction: Steroids represent a mainstay of immunosuppression after kidney transplant (KT). Steroid withdrawal reduces metabolic and cardiovascular complications, but whether it increases the risk of…2017 American Transplant Congress
Mycophenolate Dose Reductions Are Not Associated with De Novo Donor-Specific Antibodies.
University of Colorado, Aurora, CO
De novo donor-specific antibodies (dnDSA) are central to the development of antibody-mediated rejection, which is the most important cause of death-censored graft loss. It is…2017 American Transplant Congress
Antioxidant Thermoresponsive Hydrogel as a Versatile Islets Scaffolds for Treating Type I Diabetes.
Introduction: Hepatic islets transplantation procedure to treat type I diabetes often results in limited islets survival presumably due to uneven islet distribution, acute inflammatory response…2017 American Transplant Congress
Successful Launch of an ABO-Incompatible Kidney Transplantation Program to Overcome the Shortage of Compatible Living Donors: Experience at a Single Center.
Introduction:ABO-incompatible (ABOi) kidney transplantation (KT) is being increasingly performed to overcome donor shortages. However, debate persists regarding the post-transplant outcomes of ABOi KT versus that…2017 American Transplant Congress
Which Way to Go, Liver Resection or Liver Transplantation for Hepatocellular Carcinoma in Child A Liver Cirrhosis.
Introduction: Hepatocellular carcinoma(HCC) has high recurrence rate after liver resection(LR). The recurrence within Milan after LR is only 61- 79% in patient with child A.…
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