2017 American Transplant Congress
Inhibition of Heat Shock Protein 90 Suppresses the Expression of MHC Class I Molecules, but Not MHC Class II Molecules, on Endothelial Cells in Allografts.
Urology, Sapporo Medical University, Sapporo, Japan
Purpose: Heat shock protein 90 (HSP90) is a ubiquitously expressed molecular chaperone that is associated with the correct activation of client proteins. Important roles of…2017 American Transplant Congress
mTORC1 and 2 Regulate Dendritic Cell (DC) Metabolism and Allostimulatory Function of Donor DCs in Skin Transplantation.
Background/Hypothesis: The mechanistic target of rapamycin (mTOR) is a kinase that functions in two complexes: rapamycin (RAPA)-sensitive mTORC1 and RAPA-insensitive mTORC2. These complexes play critical…2017 American Transplant Congress
T-Cell Aging Parameters in the Lymph Node and Peripheral Blood Are Strongly Associated but Terminally Differentiated T Cells Are Mainly Located within the Circulation.
IntroductionAgeing is associated with changes in the peripheral T-cell immune system, which can be significantly influenced by latent cytomegalovirus (CMV)-infection. Therefore, we wanted to investigate…2017 American Transplant Congress
Second-Line Therapy After Standard of Care in Antibody-Mediated Rejection: A Prospective Study.
Paris Translational Research Center for Organ Transplantation, Paris, France
There is a marked heterogeneity in AMR patients' prognosis after SOC treatment including plasma exchange (PE) and intravenous immunoglobulins (IVIG). We investigated whether a composite…2017 American Transplant Congress
Bortezomib for Late Antibody-Mediated Rejection After Renal Transplantation: A Single Center Experience of 22 Cases.
Despite of tradifional treatments for AMR, such as plasapheresis, ingravenous immunoglobulin, and rituximab, current treatment for antibody-mediated rejection(AMR) after renal transplantation is insufficient. Recently, Bortezomib…2017 American Transplant Congress
Outcomes of Active Screening for Carbapenem-Resistant Enterobacteriaceae among Liver Transplant Recipients.
Background: Preventive strategies to combat the transmission of Carbapenem-Resistant Enterobacteriaceae (CRE) include the use of active screening for CRE colonization; however, this approach is not…2017 American Transplant Congress
Prevalence of Cutaneous Disease in Solid Organ Transplant Recipients: A 5-Year Study from a Medical -Surgical Transplant Dermatology Center.
Dermatology, Drexel University College of Medicine, Philadelphia, PA
Background: Solid organ transplant recipients (OTR) on chronic immunosuppression exhibit heightened risk of developing a myriad of cutaneous manifestations compared to non-transplant patients, including cutaneous…2017 American Transplant Congress
Gene Editing of Keap1/Nrf2 in Human T Cells Using CRISPR-Cas9 to Improve Outcome from Ischemia Reperfusion Injury and Other T Cell Mediated Diseases.
Background: T lymphocytes are important mediators of ischemia reperfusion injury (IRI) during organ transplantation. Using genetically engineered mice, we demonstrated that augmentation of Nrf2 dependent…2017 American Transplant Congress
Alternations in Amplitude of Low Frequency Fluctuation in Renal Allograft Recipients That Received Tacrolimus or Sirolimus: An fMRI Study.
Objective The side-effects of resting tremor was common in renal transplant receipts receive tacrolimus. But the mechanism of this side-effect was unknown. This study want…2017 American Transplant Congress
Immunosuppressant Costs for Medicare Part D and Kidney Transplant Recipients Since the Introduction of Generic Formulations in an Incident Kidney Transplant Population.
Background: Substitution of generics (GEN) for brand name (BN) immunosuppressants (IS) has increased in kidney transplant recipients (KTR) since the introduction of GEN mycophenolate mofetil…
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