Am J Transplant, Volume 17, Suppl 3 Archives - Page 140 of 181 - ATC Abstracts

2017 American Transplant Congress
Graft Immunocomplex Capture Fluorescence Analysis to Detect Donor Specific Antibodies and HLA Antigen Complexes in the Renal Allograft.
T. Nakamura,¹ H. Ushigome,¹ K. Watabe,² Y. Imanishi,² S. Harada,¹ S. Nobori,¹ K. Masuda,¹ N. Yoshimura.¹
¹Department of Organ Transplantation and General Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan; ²Department of Blood Transfusion and Cell Therapy, Kyoto Prefectural University of Medicine, Kyoto, Japan
Background: Immunocomplex Capture Fluorescence Analysis (ICFA) is an attractive method to detect donor specific anti-HLA antibodies (DSA) and HLA antigen complexes. Currently, antibody-mediated rejection (AMR)…
2017 American Transplant Congress
C3d-Binding Anti-DQ DSA Is Associated with a High Risk for Late ABMR and Graft Failure in Stable Kidney Transplant Recipients.
D. Lee,¹ B. Kim,² J. Kim,³ I. Kim,⁴ M. Chun.⁵
¹Medicine, Maryknoll Medical Center, Busan, Republic of Korea; ²Laboratyory Medicine, Maryknoll Medical Center, Busan, Republic of Korea; ³Surgery, Maryknoll Medical Center, Busan, Republic of Korea; ⁴Urology, Maryknoll Medical Center, Busan, Republic of Korea; ⁵Pathology, Maryknoll Medical Center, Busan, Republic of Korea
Introduction:Donor specific anti-HLA antibodies (DSA) are a major cause of antibody-mediated rejection (ABMR) and poor graft outcome in kidney transplant recipients (KTR). Critical issue is…
2017 American Transplant Congress
Inflammatory Conditions Dictate the Effect of MSC on B Cell Function.
F. Luk,¹ L. Carreras-Planella,² S. Korevaar,¹ S. de Witte,¹ F. Borràs,² M. Betjes,¹ C. Baan,¹ M. Hoogduijn,¹ M. Franquesa.^1,2
¹Nephrology and Transplantation, Dept. of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands; ²Nephrology and Transplantation, Institut d'Investigació Germans Trias i Pujol, Badalona, Spain
The immunomodulatory capacity of mesenchymal stem or stromal cells (MSC) makes them a promising therapeutic tool for immune disease and organ transplantation. The effects of…
2017 American Transplant Congress
Avoidance or Reduction of Rituximab Might Improve Clinical Outcomes in ABO-Incompatible Renal Transplantation: Advantages and Disadvantages of Rituximab.
M. Okada,¹ Y. Watarai,¹ K. Iwasaki,² K. Murotani,³ T. Hiramitsu,¹ M. Tsujita,¹ N. Goto,¹ S. Narumi,¹ T. Kobayashi.²
¹Transplant and Endocrine Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Japan; ²Renal Transplant Surgery, Aichi Medical University, Nagakute, Japan; ³Clinical Research Center, Aichi Medical University, Nagakute, Japan
BACKGROUNDPretransplant desensitization with rituximab has contributed to drastic improvements in ABO-incompatible renal transplantation (ABO-I). However, ABO-I outcomes are still worse than those of ABO-identical or…
2017 American Transplant Congress
Recurrent HCC After Radiofrequency Ablation or Liver Resection Can Be Effectively Treated with Salvage Transplantation.
H. Muaddi,¹ D. Al-Adra,¹ J. Shaw,¹ D. Grant,¹ P. Greig,¹ I. McGilvray,¹ M. Cattral,¹ A. Wei,¹ C.-A. Moulton,¹ J. Kachura,² R. Beecroft,² M. Selzner,¹ A. Ghanekar,¹ S. Gallinger,¹ S. Cleary,¹ G. Sapisochin.¹
¹General Surgery, University of Toronto, Toronto, ON, Canada; ²Medical Imaging, University of Toronto, Toronto, ON, Canada
Background:Liver resection (LR) and radiofrequency ablation (RFA) represent curative therapies for early stages of hepatocellular carcinoma (HCC). If tumour recurrence occurs, salvage liver transplant (SLT)…
2017 American Transplant Congress
Variations in Risk-Appetite Between UK Kidney Transplant Centres and Impact on Patient and Graft Outcomes.
P. Trotter,^1,2 M. Robb,² D. Summers,^1,2 J. Bradley,¹ J. Neuberger,^2,4 C. Callaghan.^2,3
¹Department of Surgery, University of Cambridge, Cambridge, United Kingdom; ²Organ Donation and Transplantation, NHS Blood and Transplant, Bristol, United Kingdom; ³Transplant Unit, Guys and St Thomas' NHS Foundation Trust, London, United Kingdom; ⁴Liver Unit, Queen Elizabeth Hospital, Birmingham, United Kingdom
Introduction: Risks associated with deceased donors may be donor-related, organ-related, or both. Variations between transplant centres in the risks they are prepared to accept ('risk…
2017 American Transplant Congress
Successful Utilization of Deceased Donor Kidney Allografts with KDPI>85: A Single Center Experience.
A. Agarwal, W. Ally, K. Brayman.
University of Virginia, Charlottesville, VA
In December 2014, UNOS implemented broad changes in the new Kidney Allocation System (KAS). Recent UNOS summary reports suggest that nationally, organ discard rates have…
2017 American Transplant Congress
MicroRNAs Differentiate Between Antibody and T-Cell Mediated Renal Allograft Rejection.
T. van den Bosch,¹ M. Clahsen-van Groningen,² F. Rezaee,³ D. Nieboer,⁴ E. Steyerberg,⁴ C. Baan,¹ A. Rowshani.¹
¹Internal Medicine, Section of Nephrology and Transplantation, Erasmus University Medical Center, Rotterdam, Netherlands; ²Pathology, Erasmus University Medical Center, Rotterdam, Netherlands; ³Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, Netherlands; ⁴Public Health, Erasmus University Medical Center, Rotterdam, Netherlands
Purpose: MicroRNAs are important immune regulators of gene and protein expression. Both circulating and intragraft expression of microRNAs have been related to renal allograft rejection.…
2017 American Transplant Congress
Medicinal Herb Cordyceps Sinensis Promotes Long-Term Allograft Survival by Tipping the Balance Between CD4+FoxP3+ Tregs and CD8+ Tcm Cells.
Z. Dai,¹ H. Dai.²
¹Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China; ²University of Pittsburgh, Pittsburgh, PA
Achieving long-term allograft survival or tolerance without continuously global immunosuppression is highly desirable in transplantation. This study was set to induce long-term allograft survival using…
2017 American Transplant Congress
Hypoxia Induces Tissue Factor Upregulation in Isolated Human Islets.
B. Sandhu,¹ M. Prendecki,¹ G. Rutter,¹ A. Martinez-Sanchez,¹ N. Kanda,¹ N. Galloway-Phillips,¹ R. Smith,² C. Pusey,¹ V. Papalois.¹
¹Imperial College, London, United Kingdom; ²King's College, London, United Kingdom
Purpose: Early islet loss post-infusion remains a significant problem in islet transplantation, despite the use of heparinised media to abrogate the effects of Tissue Factor…