ATC Abstracts

American Transplant Congress abstracts

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  • 2017 American Transplant Congress

    Assessment of Donor-Reactive T-Cell Immunity by the Novel Urine Cell-Derived Alloantigen Assay Allows Prediction of Acute Rejection in Renal Transplant Patients.

    C. Thieme,1 B. Weist,1 A. Müskes,1 P. Reinke,1 T. Westhoff,2 N. Babel.1,2

    1BCRT (Berlin-Brandenburg Center for Regenerative Therapies), Berlin, Germany; 2Ruhr University Bochum, Bochum, Germany

    Presensitization and donor-specific immunity play a major role in acute and chronic rejection of kidney transplant patients. While assessment of humoral sensitization is well standardised…
  • 2017 American Transplant Congress

    Tacrolimus and Mycophenolic Acid Have a Limited Inhibitory Effect on Monocyte Signaling Pathway Phosphorylation, Function and Differentiation.

    N. Kannegieter,1 D. Hesselink,1 M. Dieterich,1 R. Kraaijeveld,1 A. Rowshani,1 P. Leenen,2 C. Baan.1

    1Internal Medicine, Erasmus MC, Rotterdam, Netherlands; 2Immunology, Erasmus MC, Rotterdam, Netherlands

    Introduction Monocytes and macrophages play key roles in cellular and humoral rejection after solid organ transplantation, but little is known about the effects of the…
  • 2017 American Transplant Congress

    Down-Regulation of Nuclear HMGB1 by Small Interfering RNA Protects Against Liver Ischemia-Reperfusion Injury.

    G. Zhao, C. Fu, L. Wang, L. Zhu, S. Chen, G. Chen.

    Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, HUST, Wuhan, Hubei, China

    Background:High mobility group box 1 (HMGB1) was found to have both a beneficial intracellular role and injurious extracellular role after a sterile inflammatory insult.Hepatocyte-specific HMGB1…
  • 2017 American Transplant Congress

    Chronic Hepatitis E-Genotype 3 Infection in Transplant Recipients: A Single Kidney and Pancreas Transplant Centre Experience.

    A. Kousios,1 R. Charif,1 E. Sanchez,2 S. Khan,3 F. Regan,4 S. Ijaz,5 D. Muir,2 B. Smith,3 R. Tedder,5 D. Taube,1 J. Galliford.1

    1Renal and Transplant Centre, Imperial College NHS Trust, London, United Kingdom; 2Department of Infection and Immunity, Imperial College NHS Trust, London, United Kingdom; 3Department of Hepatology, Imperial College NHS Trust, London, United Kingdom; 4Department of Hematology, Imperial College NHS Trust, London, United Kingdom; 5Blood Borne Virus Unit, Virus Reference Department, MS-Colindale, Public Health England, London, United Kingdom

    Introduction:In the UK, Hepatitis E virus-genotype 3 (HEV3), is endemic and has now become the major cause of enterically transmitted viral hepatitis. Unlike HEV-genotype 1…
  • 2017 American Transplant Congress

    Risk Prediction Model for Delayed Graft Function in a Cohort of Brazilian Kidney Transplantation from Deceased Donors: What You See Is Not What You Get.

    S. Costa,1,2 T. Sandes-Freitas,1,2 E. Daher,2 R. Esmeraldo.1

    1Hospital Geral de Fortaleza, Fortaleza, Brazil; 2Federal University of Ceara, Fortaleza, Brazil

    Introduction: The estimated frequency of delayed graft function (DGF) in Brazil ranges from 50 to 70%, despite deceased donor and recipient characteristics similar to those…
  • 2017 American Transplant Congress

    Alemtuzumab Induction Is Associated with a Lower Incidence of BK Virus Nephropathy Compared with IL2RA Induction.

    A. Gueret-Wardle, S. Hassan, G. Lucisano, C. Roufosse, M. Willicombe, D. Taube.

    Renal Medicine, West London Renal and Transplant Centre, London, United Kingdom

    Introduction:BK polyoma virus associated nephropathy [BKVAN] is a major cause of allograft dysfunction and graft loss occurring in up to 10% of kidney allograft recipients…
  • 2017 American Transplant Congress

    Cross-sectional and Serial Evolution of Quality of Life in Elderly Kidney Donors.

    S. Ake,1 D. Berglund,2 S. Jackson,3 A. Matas,2 C. Gross,2 H. Ibrahim.2

    1Saint Catherine University, St. Paul; 2U of MN, Mpls; 3M Health, Mpls

    Little is known regarding long-term health-related quality of life (HRQOL) in elderly (those donating when ≥65 yrs) living kidney donors (LKDs). Using the SF-36, we…
  • 2017 American Transplant Congress

    Influence of an Enhanced Recovery Protocol in Laparoscopic Living Donor Nephrectomy.

    A. Rege, D. Vikraman, K. Ravindra, T. Brennan, H. Leraas, D. Sudan.

    Surgery, Duke University Medical Center, Durham, NC

    Background/Introduction: Enhanced recovery programs (ERPs) in colorectal surgery have decreased the duration of postoperative ileus and hospital stay while showing equivalent morbidity, mortality and readmission…
  • 2017 American Transplant Congress

    Modulating Ischemia-Reperfusion Injuries with Pharmacological Agents: A Bench-to-Bedside Approach.

    M. Thomas, G. Tardif, A. Melanger, P. Berna.

    Balmes Transplantation, Marseille, France

    Ischemia–reperfusion (IR) is a complex pathophysiological process encompassing activation of inflammatory responses and cell death programs, the severity of which critically influences both the short…
  • 2017 American Transplant Congress

    ASP0113 Elicits an Immune Response in CMV-Seronegative Dialysis Patients: Comparison to Healthy Subjects.

    P. Bonate,1 C. Van Sant,2 K. Cho,1 E. Zook,1 L. Smith,3 S. Boutsaboualoy, X. Wang,1 R. Wu,1 A. Koester,4 D. Rammelsberg,6 R. Goldwater,4 T. Marbury.5

    1Astellas Pharma Global Development, Northbrook; 2Astellas Research Institute of America, Skokie; 3Vical Inc, San Diego; 4PAREXEL International, Baltimore; 5Orlando Clinical Research Center, Orlando; 6Randstad Pharma, Deerfield, IL, United States (on assignment at Astellas Pharma Global Development, Northbrook, United States)

    Introduction: ASP0113 is a first-in-class, DNA-based vaccine in development for the prevention of CMV infection in at-risk hematopoietic cell transplant.Methods: A Phase 1, single-blind, parallel-group,…
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