ATC Abstracts

American Transplant Congress abstracts

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  • 2017 American Transplant Congress

    Low Dose Valganciclovir for CMV Prophylaxis in the First Year of Kidney Transplantation.

    P. Klem,1 L. Al-Omar,2 J. Cooper,2 S. Davis,2 J. Gralla,2 D. Choe,1 A. Wiseman.2

    1Pharmacy, University of Colorado, Aurora, CO; 2Nephrology, University of Colorado, Aurora

    Valganciclovir (VGC) is the standard antiviral agent used for the prevention of CMV diseases in moderate and high risk renal transplant recipients, yet the optimal…
  • 2017 American Transplant Congress

    Kidney Transplant Allocation with CMV Matching Reduces CMV Infection and Related Costs.

    J. Lockridge,1 E. Langewisch,2 D. Basuli,1 A. Olyaei,3 C. Shaut,4 D. Norman.1

    1Division of Nephrology, Department of Medicine, Oregon Health and Science University, Portland, OR; 2Nephrology, University of Nebraska, Omaha, NE; 3Pharmacy, Oregon Health and Sciences University, Portland, OR; 4Immunogenetics and Transplant, Oregon Health and Sciences University, Portland, OR

    Cytomegalovirus (CMV) infection is a major cause of morbidity, mortality, and shortened graft survival in kidney transplant recipients. Efforts to prevent CMV infection have traditionally…
  • 2017 American Transplant Congress

    Cost Effectiveness of Post-Prophylaxis Screening Strategies for Cytomegalovirus Viremia in CMV D+R- Kidney Transplant Recipients.

    C. Puttarajappa,1 S. Hariharan,1 K. Smith.2

    1Renal-Electrolyte Division, University of Pittsburgh, Pittsburgh, PA; 2Section of Decision Sciences, Department of Medicine, University of Pittsburgh, Pittsburgh, PA

    Purpose: To assess cost-effectiveness(CE) of screening for CMV after 6 months of valganciclovir prophylaxis in CMV high-risk (D+R-) kidney transplant recipients.Methods: A Markov model was…
  • 2017 American Transplant Congress

    Defining a BKV Cutt-Off and Profile for Early Detection of BKV Associated Nephropathy.

    C. Nihei,1 F. Agena,1 F. Paula,1 D. David,1 M. Fink,3 L. Pierrotti,2 E. David-Neto.1

    1Renal Transplantation Service, Universidade de São Paulo, São Paulo, SP, Brazil; 2Parasitic and Infectious Diseases Division, Universidade de São Paulo, São Paulo, SP, Brazil; 3Tropical Medicine Institute, Universidade de São Paulo, São Paulo, SP, Brazil

    BK polyomavirus-associated nephropathy (BKPyVAN) represents a challenge to transplant centers. Prevention using early detection of BKPy viremia (BKPyV) and immunosuppression(IS) reduction is the best current…
  • 2017 American Transplant Congress

    Functional Gain in eGFR Among Living Kidney Donors and Its Association with Remaining Kidney Volume.

    S. Hussain, A. Khalil, M. Yaqub, T. Taber, O. Adebiyi, C. Sundaram, J. Powelson, W. Goggins, A. Diez, A. Sharfuddin.

    Indiana University Health, Indianapolis

    Background:CT volumes have good correlation with nuclear imaging to measure split renal function. Kidney volume can be a surrogate marker for nephron mass. Our objectives…
  • 2017 American Transplant Congress

    Obesity Predicts New-Onset Diabetes After Live Kidney Donation.

    K. Lentine,1 A. Naik,2 N. Lam,3 M. Schnitzler,1,6 H. Xiao,1 D. Axelrod,4 G. Hess,5 B. Kasiske,6 A. Garg,7 S. Gustafson,6 D. Brennan,8 D. Segev.9,6

    1St. Louis Univ, St. Louis; 2U Michigan, Ann Arbor; 3U Alberta, Edmonton, Canada; 4E Carolina Univ, Greenville; 5Symphony Health, Philadelphia; 6Scientific Registry of Transplant Recipients, Minneapolis; 7Western Univ, London, Canada; 8Washington Univ, St. Louis; 9Johns Hopkins, Baltimore

    End-stage renal disease is uncommon in living kidney donors (LKD), but recent data suggest that most kidney failure developing late after donation is due to…
  • 2017 American Transplant Congress

    Improving Value by Standardizing the Use of IVIG Amongst Pediatric Solid Organ Transplant (SOT) Patients.

    J. Sawyer,1 J. Bucuvalas,2 L. Danziger-Isakov,3 J. Gossett,3 L. Burkhart,3 A. Lorts.3

    1Division of Pharmacy, Cincinnati Children's Hospital Medical Center, Cincinnati; 2Division of Gastroenterology, Cincinnati Children's Hospital Medical Center, Cincinnati; 3Solid Organ Transplant Center, Cincinnati Children's Hospital Medical Center, Cincinnati

    Background: Given the high cost of pharmaceuticals (i.e. IVIG), we sought to determine if unnecessary variation in drug use may be an opportunity to improve…
  • 2017 American Transplant Congress

    Improving Donor Screening for Cytomegalovirus (CMV): Is CMV IgG Avidity Better Than CMV IgM?

    H. Prince,1 M. Nowicki.1,2

    1Donor Screening Laboratory, VRL Eurofins, Los Angeles, CA; 2Mendez National Institute of Transplantation Foundation, Los Angeles, CA

    Study purpose: It is standard practice to test organ donors for CMV IgM as a marker of recent CMV infection (defined as primary infection within…
  • 2017 American Transplant Congress

    Antiretroviral Therapy Modification of HIV+ Patients Listed for Kidney Transplantation.

    D. Lee,1 G. Malat,3 T. Bias,1 S. Epstein,1 L. Levin Mizrahi,2 M. Harhay,2 S. Talluri,2 K. Ranganna.2

    1Division of Infectious Diseases and HIV Medicine, Drexel University College of Medicine, Philadelphia; 2Division of Nephrology, Drexel University College of Medicine, Philadelphia; 3Department of Surgery, Drexel University College of Medicine, Philadelphia

    Introduction:HIV+ individuals can receive kidney transplant (KT) safely and effectively but face additional challenges from potential drug interactions between antiretroviral therapy (ART) and immunosuppression(IS). Little…
  • 2017 American Transplant Congress

    Differences in Kinetics of IFN-y Production Between Endogenous and Allotransplant-Induced Memory T Cells.

    B. Gonzalez-Nolasco, J. Marino, W. Orent, G. Benichou.

    Center for Transplantation Sciences, Massachusetts General Hospital / Harvard Medical School, Boston, MA

    Background:CD8+ memory T cells produce IFN-g in a faster and stronger fashion than their naïve counterparts after allorecognition. Unmanipulated mice possess a proportion of endogenous…
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