Am J Transplant, Volume 17, Suppl 3 Archives - Page 139 of 181 - ATC Abstracts

2017 American Transplant Congress
Induction Therapy in Low Risk Elderly Kidney Transplant Recipients: Donor Factors.
F. Al Ammary, M. DeMarco, Q. Huang, E. King, S. Bay, A. Muzaale, A. Wiseman, D. Segev.
Johns Hopkins, Baltimore; University of Colorado, Denver
It is not known whether depleting induction is needed in low-risk elderly kidney transplant (KT) recipients in whom concern for infectious and complications is higher…
2017 American Transplant Congress
A Mutation of the Erythropoietin Receptor Correlates with Improved Function of Deceased-Donor Renal Transplants.
M. Fischereder,¹ S. Friedrich,¹ U. Klingmüller,² T. Kauke,³ T. Breidenbach,⁴ D. Boesebeck,⁵ E. Angelika,⁵ C. Cohen,¹ B. Banas,⁶ M. Guba,⁷ M. Stangl,⁸ B. Krämer,⁹ C. Hugo,¹⁰ K. Lopau,¹¹ M. Stadtler,¹² T. Mone.¹²
¹Medizinische Klinik IV, Klinikum der LMU, Munich, Germany; ²DKFZ, Heidelberg, Germany; ³Klinikum der LMU, Munich, Germany; ⁴Chirurgische Klinik, Klinikum Augsburg, Augsburg, Germany; ⁵DSO Bayern, Munich, Germany; ⁶Nephrologie, Universitätsklinikum, Regensburg, Germany; ⁷Surgery, Klinikum der LMU, Munich, Germany; ⁸Surgery, Klinikum der TU, Munich, Germany; ⁹Innere Medizin IV, Universitätsklinikum, Mannheim, Germany; ¹⁰Innere Medizin, Universität Erlangen, Erlangen, Germany; ¹¹Innere Medizin 2, Universitätsklinikum, Würzburg, Germany; ¹²OneLegacy, Los Angeles
Erythropoietin (Epo) protects renal tubular cells from ischemia/reperfusion injury in experimental transplantation, suggesting a relevant effect of erythropoietin receptor (EPOR) mediated signalling. Previously 6 mutations…
2017 American Transplant Congress
Donor Derived Transmission Events in 2015-2016: Analysis of the OPTN Ad Hoc Disease Transmission Advisory Committee (DTAC).
C. Wolfe,¹ M. Clark,² S. Tlusty,² D. Kaul,¹ M. Michaels.¹
¹DTAC, Richmond; ²United Network for Organ Sharing, Richmond
The OPTN DTAC, a multidisciplinary committee, evaluates potential donor derived transmission events (PDDTE), including mostly infections (I) & malignancies (M), to assess for likelihood of…
2017 American Transplant Congress
Outcomes Following Cholecystectomy in Kidney Transplant Recipients.
S. DiBrito, C. Holscher, I. Olorundare, C. Haugen, Y. Alimi, D. Segev, J. Garonzik-Wang.
JHU, Baltimore
Cholecystectomy is one of the most common general surgical procedures. Given the need for lifelong immunosuppression and the physiologic impact of years of renal replacement,…
2017 American Transplant Congress
CD8+ TAb-supp Cells Suppress the Production of Multiple Alloantibody Isotypes in Response to MHC-Mismatched Cellular and Vascularized Allografts.
J. Zimmerer, C. Avila, S. Elzein, B. Ringwald, G. Bumgardner.
Surgery, The Ohio State University Wexner Medical Center, Columbus, OH
We have reported that a CD8+ T cell subset, we termed CD8+ TAb-supp cells, inhibits the production of alloAb after hepatocyte transplant (HcTx) in part…
2017 American Transplant Congress
Dramatic Shifts in Prognosis, Outcomes and Baseline Risk Among Wait Listed Kidney Transplant Candidates in the United States.
J. Schold, E. Poggio, L. Buccini, S. Flechner, J. Augustine, D. Goldfarb.
Cleveland Clinic, Cleveland, OH
Introduction and MethodsOver the past decades there have been numerous clinical advances and policy changes affecting candidates for kidney transplantation. Our aim was to evaluate…
2017 American Transplant Congress
Belatacept Conversion in Kidney Recipients with Low GFR Does Not Improve Renal Function.
D. Abdelwahab,¹ S. Byron,² B. Kaplan,¹ R. Heilman.¹
¹Transplant, Mayo Clinic, Scottsdale, AZ; ²Biostatistics and Informatics, Mayo Clinic, Rochester, MN
Background:Belatacept interferes with signal 2 of T cell activation via blockade CD80/86 which doesn't adversely impact renal function. We tested a hypothesis that Belatacept conversion…
2017 American Transplant Congress
Clinical Outcomes of ABO and HLA Incompatible Kidney Transplantation – Nationwide Cohort Study.
E. Ko,^1,2 J. Yu,^1,2 C. Yang,^1,2 B. Chung,^1,2 Korean Organ Transplantation Registry (KOTRY).
¹Transplantation Research Center, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea; ²Division of Nephrology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
Background This is a nationwide cohort study to investigate the impact of anti-A/B antibody or donor specific anti-HLA antibody (HLA-DSA) on the clinical outcomes in…
2017 American Transplant Congress
Accumulating Mitochondrial DNA in Aging Augments Inflammatory Responses Subsequent to IRI.
M. Seyda,^1,2 M. Quante,¹ T. Heinbokel,¹ G. Liu,¹ H. Uehara,¹ J. Schuitenmaker,¹ R. Abdi,³ C. Falk,² A. Elkhal,¹ S. Tullius.¹
¹Division of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women's Hospital/Harvard Medical School, Boston; ²Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany; ³Renal Division, Schuster Family Transplant Center, Brigham and Women's Hospital, Boston
Background: Older donor organs are increasingly utilized to close the gap between demand and supply. We submit that aging-associated kinetics of damage associated molecular patterns…
2017 American Transplant Congress
Tissue Transcriptional Profile of Portal Inflammation with Interface Activity in Pediatric Liver Transplant (LT) Recipients with Normal Liver Tests Closely Resembles T Cell Mediated Rejection (TCMR).
A. Sanchez-Fueyo, S. Feng, A. Demetris, J. Bucuvalas, J. Lozano, J. Magee, K. Spain, S. Kanaparthi, iWITH Investigators.
KCL, London, United Kingdom; UCSF, SF; Pittsburgh, Pittsburgh; Cincinnati, Cincinnati; CiberEHD, Barcelona, Spain; Michigan, Ann Arbor; Rho, Chapel Hill; ITN, Bethesda; NIDDK/NIAID/NIH, Bethesda
Background: Significant inflammation±fibrosis is frequently seen in biopsies (bxs) of pediatric LT recipients with normal liver tests assessed for immunosuppression withdrawal. The pathogenesis of these…