2017 American Transplant Congress
IP-10 Monoclonal Antibody Treatment Suppresses Inflammatory Components of IBMIR and Improves Pancreatic Islet Graft Function.
Introduction: An instant blood-mediated inflammatory response (IBMIR) causes acute loss of pancreatic islets. Interferon gamma-induced protein 10 (IP-10) is a key proinflammatory chemokine that may…2017 American Transplant Congress
Novel Biomarkers for Segregating Lung Transplant Rejection Phenotypes.
We sought to investigate biomarkers in BAL fluid and tissue for segregating BOS and RAS chronic rejection phenotypes in lung allografts. We had previously identified…2017 American Transplant Congress
Urine Biomarkers (UBio) Correlate Poorly with Pre-Liver Transplant (LT) Kidney Biopsy Findings and Post-LT Kidney Function.
UBio might be valuable in determining the etiology of renal dysfunction in LT candidates.Aim: Correlate UBio with pre-LT kidney biopsy and post-LT kidney function.Methods:78 LT…2017 American Transplant Congress
Human IL-10 Transfection of Porcine Lungs Significantly Increases IL-10 Levels in Vascular Perfusate During Human Blood Perfusion.
PurposePorcine organs are a potential source for clinical xenotransplantation. Pig lungs perfused with human blood exhibit inflammation and loss of vascular barrier function within hours.…2017 American Transplant Congress
Focal Segmental Glomerulosclerosis Recurrence in Renal Transplant Recipients Treated with Belatacept.
Emory Transplant Center, Atlanta, GA
Introduction: Focal segmental glomerulosclerosis (FSGS) is a cause of end-stage renal failure that frequently recurs following renal transplant, often leading to allograft loss. A recently…2017 American Transplant Congress
Comparison of Long Term Renal Function Outcomes for Everolimus (EVR) vs. Sirolimus (SIR) vs. Mycophenolate Acid (MPA) Immunosuppressive Regimens Post Kidney Transplant (Ktx).
MPA or mammalian target of rapamycin inhibitors (mTORi [EVR or SIR]) in combination with calcineurin inhibitors (CNI, tacrolimus [TAC] or cyclosporine) are used for maintenance…2017 American Transplant Congress
A Critical Analysis of Equations for MPA Exposure in Patients Under EC-MPS and Tacrolimus.
Hospital das Clinicas FMUSP, Sao Paulo, Brazil
Mycophenolic acid(MPA) PK, from enteric-coated mycophenolate sodium(EC-MPS) has a broad range of Tmax avoiding the use a single concentration to calculate the area-under-the-time-concentration curve(AUC). Either…2017 American Transplant Congress
Long-Term Outcomes in HIV(+) Kidney Re-Tranpslant (ReTx) Recipients vs. Primary Transplant (PrimTx) Recipients.
Drexel University College of Medicine, Philadelphia
Hahnemann University Hospital has performed 113 kidney transplants, including 7 ReTx. Herein we describe characteristics and allograft outcomes of HIV(+) kidney transplant recipients based on…2017 American Transplant Congress
Association Between Matrix-gla Protein Levels and Aortic Stiffness in Kidney Transplantation.
INTRODUCTIONAortic stiffness due to vascular calcifications is commonly observed among kidney transplant recipients and is considered as a predictive factor of poor events such as…2017 American Transplant Congress
Albuminuria in Kidney Transplant Patients Is Associated with Increased Urine Serine Proteases with the Ability to Activate ENaC.
Background In patients with renal transplant albuminuria is associated with salt-sensitive hypertension. Aberrantly filtered serine proteases e.g. plasmin has shown to activate ENaC through proteolytic…
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