Am J Transplant, Volume 17, Suppl 3 Archives - Page 131 of 181 - ATC Abstracts

2017 American Transplant Congress
IdeS, an IgG Endopeptidase, Effectively Cleaves Anti-HLA Antibody (Ab), Resulting in Inhibition of Anti-HLA Ab-Mediated NK Cell Activation and Ab-Dependent Cell-Mediated Cytotoxicity (ADCC) in HLA-Sensitized Kidney Transplant Patients (HS KTx Pts).
S. Ge, M. Chu, J. Choi, S. Louie, A. Kang, A. Vo, A. Peng, S. Jordan, M. Toyoda.
Transplant Immunology Laboratory and Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
Background: Ab-mediated rejection (ABMR) is a major obstacle in HS KTx Pts. ADCC is a mechanism responsible for ABMR. IdeS cleaves all 4 human IgG…
2017 American Transplant Congress
Donor-Derived Cell-Free DNA Normal Range and Biological Variation Defined in a Reference Population.
J. Bromberg,¹ D. Brennan,² E. Poggio,³ D. Hiller,⁴ R. Woodward,⁴ J. Yee,⁴ J. Sninsky,⁴ R. Bloom.⁵
¹University of Maryland, Baltimiore, MD; ²Washington University, St. Louis, MO; ³Cleveland Clinic, Cleveland, OH; ⁴CareDx, Brisbane, CA; ⁵University of Pennsylvania, Philadelphia, PA
Purpose: Donor-derived cell-free DNA (dd-cfDNA) in the circulating blood of transplant recipients has shown promise as a non-invasive biomarker of acute rejection. This analysis was…
2017 American Transplant Congress
Uromodulin and Toll-Like Receptor 4 Levels Predict Susceptibility to Bacterial Urinary Tract Infection After Renal Transplantation.
K. Stahl,¹ H. Lührs,¹ J. Schmitz,² I. Scheffner,¹ W. Gwinner,¹ J. Bräsen,² H. Haller,¹ M. Schiffer.¹
¹Internal Medicine, Nephrology, Hannover Medical School, Hannover, Germany; ²Pathology, Hannover Medical School, Hannover, Germany
Background: Urinary tract infection (UTI) remains the most common bacterial infection after kidney transplantation (kTx) and is associated with reduced allograft function as well as…
2017 American Transplant Congress
Risk Factors for Cryptococcal Disease in Transplant as Compared with Non-Transplant Patients: A Single Center Study.
O. Beaird,¹ O. Garner,² R. Humphries,² J. Schaenman.¹
¹David Geffen School of Medicine at UCLA, Los Angeles, CA; ²UCLA Pathology & Laboratory Medicine, Los Angeles, CA
Purpose: To examine clinical characteristics of non-HIV, immunocompromised patients diagnosed with cryptococcal disease, including solid-organ transplant (SOT) recipients.Methods: We performed retrospective chart review of non-HIV,…
2017 American Transplant Congress
Proteasome Modulation an Effective Strategy to Ameliorate Steatotic Liver Grafts Viability After Preservation.
M. Zaouali,¹ A. Panisello Roselló,¹ T. Carbonell,² A. Garcia-Gil,³ A. Lopez,⁴ R. Adam,⁴ J. Rosello-Catafau.¹
¹Patología Experimental, Instituto de Investigaciones Biomédicas de Barcelona, CSIC, Barcelona, Spain; ²Phisiology, Fac. of Biology, Universitat de Barcelona, Barcelona, Spain; ³Transplantation, Hospital Clínico, Zaragoza, Spain; ⁴Hepato- Biliare Unit, Hôpital Paul Brousse, INSERM U-776, Université Paris Sud, Paris, France
Recently we provided evidence for a possible protective role of proteasome inhibition during liver graft preservation. Although, several reported data confirmed that the proteolytic activity…
2017 American Transplant Congress
Outcomes of Renal Disease Related to Monoclonal Gammopathy After Kidney Transplantation: A Single Center Experience.
T. Kaur, E. Poggio, S. Nurko.
Nephrology, Cleveland Clinic, Cleveland
Kidneys are commonly involved in patients with monoclonal gammopathies (MG). However, the role of kidney transplants (KTx) in MG still needs to be more clearly…
2017 American Transplant Congress
The Adoption of Generic Immunosuppressant Medications Among Kidney and Liver Transplant Recipients Using the Colorado All Payer Claims Database.
Q. Liu,¹ A. Smith,¹ J. Park,² M. Oguntimein,³ S. Dutcher,³ G. Bello,¹ M. Helmuth,¹ M. Turenne,¹ R. Balkrishnan,⁴ M. Fava,¹ P. Sharma,² C. Beil,¹ A. Leichtman,¹ J. Zee.¹
¹Arbor Research Collaborative for Health, Ann Arbor, MI; ²U of Michigan, Ann Arbor, MI; ³Food and Drug Administration, Silver Spring, MD; ⁴U of Virginia, Charlottesville, VA
Background: Substitution of generic for brand-name immunosuppressants has increased in solid organ transplantation following the expiration of brand patents. Our aim was to describe the…
2017 American Transplant Congress
Does Choice of Induction Agent Affect Outcomes in Kidney Transplants from Deceased Donors with Acute Kidney Injury and Prolonged Cold Ischemia Time?
G. Dube, S. Mohan, M. Chiles.
Nephrology, Columbia University Medical Center, New York, NY
Kidneys with acute kidney injury (AKI) have a higher rate of DGF but similar outcomes to kidneys without AKI, although most data are with kidneys…
2017 American Transplant Congress
Early Rejection in the Elderly: Is It Predictable?
J. Clark, T. Sparkes, B. Masters, S. Jonchhe, A. Haririan, B. Thomas, B. Ravichandran.
University of Maryland Medical Center, Baltimore, MD
Introduction: Optimal induction for elderly kidney transplant recipients (KTR) remains unclear. Older age may be associated with decreased immunogenicity; however, clinical heterogeneity of the elderly…
2017 American Transplant Congress
Lactate Level Immediate Post-Liver Transplantation Is a Predictor of Early Allograft Dysfunction.
K. Takahashi,^1,2 S. Nagai,¹ M. Safwan,¹ K. Putchakayala,¹ K. Collins,¹ M. Rizzari,¹ A. Yoshida,¹ M. Abouljoud,¹ S.-M. Jafri.³
¹Transplant and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, MI; ²Surgery, University of Tsukuba, Tsukuba, Ibaraki, Japan; ³Gastroenterology, Henry Ford Hospital, Detroit, MI
Background; Early allograft dysfunction (EAD) after liver transplantation (LT) is defined as a peak values of aminotransferase >2000 IU/mL during the first week or an…