Am J Transplant, Volume 17, Suppl 3 Archives - Page 128 of 181 - ATC Abstracts

2017 American Transplant Congress
Alcohol-Induced Hepatic Cirrhosis Is Rising Among Young Adults.
C. Kling,¹ J. Perkins,¹ D. Donovan,² R. Carithers,³ L. Sibulesky.¹
¹Division of Transplant Surgery, University of Washington, Seattle, WA; ²Department of Psychiatry & Behavioral Sciences, University of Washington, Seattle, WA; ³Division of Hepatology, University of Washington, Seattle, WA
Background: Alcoholic cirrhosis is a common indication for liver transplantation. Recent population studies have shown no change in the overall prevalence of alcohol use, but…
2017 American Transplant Congress
Myeloid-Derived Suppressor Cells (MDSC) Accumulate in Intestinal Transplant (IT) Recipients (rc) and Suppress Recipient T-Cell (T) Response Against Donor Antigen.
S. Okano,¹ D. Kish,² K. Keslar,² W. Baldwin,² R. Fairchild,¹ C. Miller,¹ K. Abu-Elmagd,¹ A. Khanna,¹ M. Fujiki,¹ J. Fung,¹ G. Costa,¹ K. Hashimoto.¹
¹Transplant Center, Dept. General Surgery, Digestive Disease & Surgery Institute, Cleveland Clinic, Cleveland, OH; ²Dept. Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH
[Introduction] Recent advances of immunosuppressive regimens have decreased rejection rate and improved rc survival of IT. MDSC are potent immature myeloid cells capable of suppressing…
2017 American Transplant Congress
Prolonged Survival with Co-Stimulatory Blockade Based Immunosuppression in Pig-to-Primate Liver Xenotransplantation.
J. Shah, M. Patel, N. Elias, I. Rosales, N. Navarro-Alvarez, M. Hertl, A. Cosimi, R. Colvin, J. Markmann, D. Sachs, P. Vagefi.
Massachusetts General Hospital, Boston, MA
Background: Since the first attempt in 1968, survival following pig-to-baboon liver xenotransplantation (LXT) has been limited to <9-days due to a lethal coagulopathy. To improve…
2017 American Transplant Congress
Higher Mortality Among Candidates Who Refused Increased-Infectious Risk Kidney Offers.
M. Bowring, L. Kucirka, A. Massie, C. Holscher, D. Segev.
JHU, Baltimore
Increased infectious risk donors (IRD) are younger and healthier than most deceased donors, but IRD kidneys are discarded at higher rates despite potential benefit to…
2017 American Transplant Congress
The New Kidney Allocation System in France Meets it's Targets: Improving Age and HLA DR-QD Matching for Young Adults.
C. Jacquelinet, B. Audry, F. Bayer, M. Macher.
Direction Medicale et Scientifique, Agence de la Biomedecine, Saint-Denis, France
A new KAS was implemented in France as of February 2015, resulting from an intensive 3 yrs-simulation work in interaction with KTx advisory committee and…
2017 American Transplant Congress
Long-Term Outcomes After Liver Transplantation (tx) with Everolimus (EVR) and Mycophenolic Acid (MPA) in a Calcineurin Inhibitor-Free Regimen: The CERTITUDE Trial.
F. Saliba,¹ C. Duvoux,² S. Dharancy,³ J. Dumortier,⁴ Y. Calmus,⁵ F. Di Giambattista,⁶ F. Conti.⁵
¹AP-HP Hôpital Paul Brousse, Villejuif, France; ²AP-HP Hôpital Henri Mondor, Créteil, France; ³CHRU de Lille, Lille, France; ⁴Hôpital Edouard Herriot, Lyon, France; ⁵AP-HP Hôpital Pitié Salpêtrière, Paris, France; ⁶Novartis Pharma SAS, Rueil-Malmaison, France
Background. Long-term outcomes under EVR with MPA and no calcineurin inhibitor are undocumented after liver tx.Methods. CERTITUDE is a prospective, multicenter, observational study of liver…
2017 American Transplant Congress
A Novel Belatacept Regimen to Optimize Efficacy and Safety.
D. Wojciechowski,¹ S. Chandran,² M. Sarwal,² J. Yang,² F. Vincenti.²
¹MGH, Boston; ²UCSF, San Francisco
Despite superior long term graft survival when compared to cyclosporine, the use of the FDA approved belatacept regimen in clinical practice has been constrained by…
2017 American Transplant Congress
Rituximab Desensitization (DES) and Alemtuzumab Induction Significantly Reduced EBV Viremia and Post-Transplant Lymphoproliferative Disorder (PTLD) in HLA-Sensitized (HS) Kidney Transplant Patients.
B.-H. Shin,¹ S. Ge,¹ J. Mirocha,² D. Thomas,¹ E. Rodriguez,¹ C. Chao,¹ O. Galera,¹ A. Vo,¹ J. Choi,¹ A. Peng,¹ J. Kahwaji,¹ S. Jordan,¹ M. Toyoda.¹
¹Transplant Immunology Laboratory and Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA; ²Biostatistics Core, Cedars-Sinai Medical Center/UCLA School of Medicine, Los Angeles, CA
Background: PTLD is a serious complication in KTx pts and is usually associated with EBV infection. Recent studies showed that rituximab treatment prior to Tx…
2017 American Transplant Congress
Inflammasome, Unfolded Protein Response, and T Cell Immunity in DAIH.
A. Arterbery,¹ M. Martinez,³ S. Lobritto,³ Y. Avitzur,² U. Ekong.¹
¹Ped Gastro. and Hep., Yale University, New Haven, CT; ²Gastro., Hep., and Nutr., Hospital for Sick Children, Toronto, ON, Canada; ³Ped. Gastro., Hep., and Nutr., Columbia University, New York, NY
Background: Regulatory T cells (Tregs) of patients with de novo autoimmune hepatitis (DAIH) secrete IL-17A & IFN-g; display TH1 & TH17 pehnotypes & are functionally…
2017 American Transplant Congress
Circulating Donor-Specific Memory B Cells (mBc) Discriminates Kidney Transplant Patients with Histological Lesions of ABMR in Absence of Circulating DSA.
S. Luque,² M. Lúcia,⁴ M. Jarque,² E. Crespo,² E. Melilli,¹ J. Martorell,³ J. Cruzado,^1,2 J. Torras,^1,2 J. Grinyó,^1,2 O. Bestard.^1,2
¹Kidney Transplant Unit, Nephrology Department, Bellvitge University Hospital, Barcelona, Catalunya, Spain; ²Experimental Nephrology Laboratory, IDIBELL, Barcelona, Catalunya, Spain; ³Immunogenetics Laboratory, Hospital Clínic, Barcelona, Catalunya, Spain; ⁴Transplant Immunology, School of Medicine, Stanford
Chronic (c)ABMR is a main cause of immune-mediated kidney allograft loss. For its diagnosis, specific histological lesions together with presence of circulating donor-specific alloantibodies (DSA)…