Am J Transplant, Volume 17, Suppl 3 Archives - Page 127 of 181 - ATC Abstracts

2017 American Transplant Congress
Strategy for Analysis of Donor-Specific Antibody Repertoire: Paired Immunoglobulin Heavy and Light Chain Analysis of Individual Memory B Cells.
M. Lucia,¹ A. Gomez,² S. Luque,³ O. Bestard,³ W. Robinson,² O. Martinez.¹
¹Surgery, Stanford School of Medicine, Stanford; ²Medicine, Stanford School of Medicine, Stanford; ³Nephrology, IDIBELL, Barcelona, Catalonia, Spain
Antibody-mediated rejection (ABMR) is the most challenging immunological barrier to overcome in human transplantation and one of the most prevalent causes of kidney allograft loss.…
2017 American Transplant Congress
Training for Transplant: Frailty Assessment and Optimization in Kidney Transplant Candidates.
M. Mrdutt, D. Doherty, S. Tanner, J. Lappin.
Surgery, Scott & White Medical Center, Temple, TX
Purpose: To design and implement a frailty assessment and optimization program addressing potential modifiable risk factors that would ordinarily disqualify patients from kidney and/or pancreas…
2017 American Transplant Congress
How Much Is a Kidney Worth? Comparing Kidney Transplant Strategies in Liver Transplant Candidates.
X. Cheng,¹ W. Kim,² J. Tan,¹ J. Goldhaber-Fiebert.³
¹Div Nephrology, ; ²Div Gastroenterology & Hepatology, ; ³Ctr Health Policy, Stanford U, Palo Alto
The number of simultaneous liver-kidney (SLK) transplants for renal failure complicating end-stage liver disease (ESLD) is rising. The Organ Procurement and Transplant Network (OPTN) will…
2017 American Transplant Congress
Impact of Type of Recipient Diabetes on 1 and 3-Year Kidney Allograft and Patient Outcomes.
S. Kim, F. Wu, D. Cibrik, Y. Li, A. Naik.
University of Michigan, Ann Arbor
The pathophysiology of type 1 (T1DM) and type 2 (T2DM) diabetes is different and has been conjectured to impact transplantation outcomes differently over time especially…
2017 American Transplant Congress
Largest US Series of Minimally Invasive Full and Laparoscopy-Assisted Living Donor Hepatectomy.
K. Collins, J. Emond, A. Fox, B. Samstein.
Surgery, New York Presbyterian/Columbia University, New York, NY
Columbia University Medical Center (CUMC) has offered minimally invasive donor hepatectomies since 2008. Donor hepatectomies have been performed using 3 access routes (1) hybrid technique;…
2017 American Transplant Congress
Utility of IL-2 Complexes in Promoting Vascularized Composite Allograft Survival.
H. Xu,¹ S. Dahiya,² L. Wang,² T. Akimova,² W. Hancock,^2,4 S. Levin.³
¹Plastic and Reconstructive Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; ²Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia; ³Orthopaedic Surgery, Hospital of the University of Pennsylvania, Philadelphia; ⁴Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia
Vascularized composite allografts (VCA) are a novel, life-enhancing form of transplantation (Tx). The complexity of host immune responses to VCA tissues, especially those involving skin,…
2017 American Transplant Congress
Specific Gene Expression Signature of Complement-Activating Donor Specific Anti-HLA Antibody-Mediated Rejection in Kidney Allografts.
C. Lefaucheur,¹ D. Viglietti,¹ L. Hidalgo,² O. Aubert,¹ A. Zeevi,³ P. Halloran,² A. Loupy.¹
¹Paris Translational Research Center for Organ Transplantation, Paris, France; ²University of Alberta, Edmonton, Canada; ³University of Pittsburgh Medical Center, Pittsburgh
Complement-binding anti-HLA DSA have demonstrated higher rejection rate and decreased allograft survival. However, their specific effects on rejection pathogenesis have not been identified. We investigated…
2017 American Transplant Congress
Assessment of Simple Indices Based on a Single Fasting Blood Sample in Search for an Optimal Tool to Estimate Beta Cell Function After Islet Transplantation.
J. Golebiewska,¹ J. Solomina,² E. Konsur,² K. Cieply,² L. Basto,² A. Kotukhov,² K. Golab,² C. Thomas,³ A. Debska-Slizien,¹ P. Witkowski.²
¹Department of Nephrology, Medical University of Gdansk, Gdansk, Poland; ²Departemt of Surgery, University of Chicago, Chicago; ³Department of Medicine, University of Chicago, Chicago
Background:Precise yet logistically feasible evaluation of beta-cell function is extremely important after islet allotransplantation. We investigated the utility and possible limitations of indices using only…
2017 American Transplant Congress
Donor Recipient Matching Based on HLA Epitopes Improves Outcome in Kidney Transplant Recipients.
O. Staeck,¹ M. Niemann,³ F. Halleck,¹ D. Khadzhynov,¹ C. Schönemann,² P. Reinke,¹ E. Spierings,⁴ K. Budde,¹ N. Lachmann.²
¹Nephrology, Charité Universitaetsmedizin, Berlin, Germany; ²HLA Laboratory, Charité Universitaetsmedizin, Berlin, Germany; ³PIRCHE, Berlin, Germany; ⁴Laboratory of Translational Immunology, UMC Utrecht, Utrecht, Netherlands
Background: HLA mismatches of the donor and recipient causing de novo donor-specific HLA antibodies (dnDSA) are a risk factor for immunologic complications and poor graft…
2017 American Transplant Congress
Gut Microbial Metabolite Improves Function and Prolongs Kidney Allograft Survival in Mice.
H. Wu,^1,2 T. Kwan,¹ Y. Loh,¹ X. Chen,¹ L. Macia,^2,3 S. Alexander,^2,4 S. Chadban.^1,2
¹Kidney Node Laboratory, The Charles Perkins Centre and Renal Medicine, Sydney Medical School and Royal Prince Alfred Hospital, Sydney, Australia; ²University of Sydney, Sydney, Australia; ³Nutritional Immunometabolism Lab, The Charles Perkins Centre, Sydney Medical School, Sydney, Australia; ⁴Nephrology Department, The Children Hospital at Westmead, Sydney, Australia
To determine the impact of dietary administration of the gut microbial metabolite sodium acetate (SA) on kidney rejection and survival in a fully MHC-mismatched murine…