ATC Abstracts

American Transplant Congress abstracts

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  • 2017 American Transplant Congress

    Allograft Cytokine Activation and Elevated Tissue Indoleamine 2,3-Dioxygenase Gene and Protein Expression in Rejecting Pig Transplants.

    T. Merchen,1 Y. Wang,2 R. Lassiter,1 D. Kleven,3 R. Jajosky,3 M. Winn,2 C.-S. Ho,5 N. Nahman.4

    1Surgery, MCG at Augusta University, Augusta, GA; 2Medicine, MCG at Augusta University, Augusta, GA; 3Pathology, MCG at Augusta University, Augusta, GA; 4Norwood VAMC, Augusta, GA; 5Gift of Life Michigan, Ann Arbor, MI

    Viral delivery of the indoleamine 2,3-dioxygenase (IDO) transgene results in transprotein synthesis and mitigates rejection in rodent kidney transplants (J Gene Med 13:373); but in…
  • 2017 American Transplant Congress

    Tofacitinib-Loaded Solid Lipid Nanoparticles Inhibits Dendritic Cell Antigen Presenting Functions and Achieve Selective In Vivo Targeting.

    G. Raimondi,1 X. Calderon-Colon,2 J. Budihardjo,1 A. Mirdad,1 M. Iglesias-Lozano,1 J. Walch,1 W. Lee,1 G. Brandacher,1 J. Patrone.2

    1Plastic & Reconstructive Surgery, Johns Hopkins University, Baltimore; 2Johns Hopkins Applied Physics Laboratory, Laurel

    BackgroundComplications from long-term use of calcineurin inhibitors are a major concern for transplant patients. To develop CNI-free therapies, we investigated an innovative drug delivery method…
  • 2017 American Transplant Congress

    A New and Potent Distal Enhancer of the IL2 Gene.

    R. Thomas,1 P. Mehra,1 M. Johnson,2 S. Grant,2 A. Wells.1

    1Pathology, The Children's Hospital of Philadelphia, Philadelphia, PA; 2Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA

    Interleukin-2 is a potent T cell growth factor with crucial roles in both immunity and tolerance. Genetic studies in humans and mice demonstrate a role…
  • 2017 American Transplant Congress

    Microvascular Inflammation at 4 Months Posttransplant Is Associated with Transplant Glomerulopathy at One and Two Years Independent of Rejection and Donor Specific Antibodies.

    H. Khamash, G. Mour, L. Archambault, M. Buras, H. Kosiorek, M. Pando, K. Reddy, H. Chakkera, J. Huskey, S. Nair, A. Jaramillo, M. Smith, B. Kaplan, R. Heilman.

    Mayo Clinic Arizona, Phoenix

    Aim: Study factors that are associated with transplant glomerulopathy (TG) in flowcytometric crossmatch negative kidney transplant recipients with no desensitization.Methods:Single center retrospective analysis of characteristics…
  • 2017 American Transplant Congress

    Incidence of Donor-Specific Anti-HLA Antibodies in Non-HLA Sensitized Patients Given Tacrolimus Once or Twice Daily During the First Two Years Post-Transplantation.

    N. Kamar, V. Hajj, I. Ferrandiz, E. Younes, L. Esposito, A. Hébral, A. Del Bello.

    Department of Nephrology and Organ Transplantation, Toulouse University Hospital, Toulouse, France

    Donor-specific anti-HLA antibody (DSA)-mediated rejection (AMR) is a main cause of graft loss after kidney transplantation. Non-adherence is a risk factor for AMR and graft…
  • 2017 American Transplant Congress

    Evaluation of Vancomycin Resistant Enterococcus (VRE) Colonization and Infection Rate in Adult Liver Transplant Patients.

    E. Aldag,1 G. Fouth,1 R. Pedersen,1 L. Fehrenbacher,1,2 A. Sahajpal,1 V. Gunabushanam,1 D. Kramer.1

    1Aurora St Luke's Medical Center, Milwaukee; 2Concordia University Wisconsin School of Pharmacy, Mequon

    Background: VRE infections are associated with higher morbidity and mortality among patients undergoing liver transplantation.Objective: The primary outcomes are to look at VRE infection rate…
  • 2017 American Transplant Congress

    AAV8 Delivery of TIMP-1 Prevents Hepatocyte Apoptosis After Liver Ischemia/Reperfusion Injury.

    S. Duarte, P. Matian, M. Miller, R. Busuttil, A. Coito.

    Dumont-UCLA Transplant Center, Los Angeles

    Matrix metalloproteinase-9 (MMP-9) is a key mediator of leukocyte migration across vascular barriers in hepatic ischemia/reperfusion injury (IRI). Tissue inhibitor of metalloproteinase-1 (TIMP-1) is the…
  • 2017 American Transplant Congress

    Nuclear Co-Repressor Complex Inhibition Reverses Benefit of HDAC2 Deletion in Renal Ischemia.

    D. Aufhauser Jr,1 D. Murken,1 Z. Wang,1 A. Samanta,2 G. Ge,1 T. Bhatti,3 P. Cole,4 J. Kalin,4 W. Hancock,2,3 M. Levine.1,5

    1Surgery, University of Pennsylvania, Philadelphia, PA; 2Pathology, University of Pennsylvania, Philadelphia, PA; 3Pathology, Children's Hospital of Philadelphia, Philadelphia, PA; 4Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, MD; 5Surgery, Children's Hospital of Philadelphia, Philadelphia, PA

    Introduction: Class I histone/protein deacetylases (HDACs) 1 and 2 bear >85% protein sequence homology and conventionally are thought to have similar function via occupancy in…
  • 2017 American Transplant Congress

    Model to Predict Prolonged Delayed Graft Function (DGF) Following Kidney Transplantation from Deceased Donor with Acute Kidney Injury (AKI Tx).

    R. Heilman,1 B. Smith,2 C. Johnson,1 H. Khamash,1 K. Reddy,1 W. Kremers,2 B. Kaplan.1

    1Mayo Clinic, Phoenix, AZ; 2Mayo Clinic, Rochester, MN

    Background Our aim is to develop a model to predict prolonged DGF following AKI Tx.Methods AKI Tx (donor terminal Cr>/=2) from 2003 to 2016 were…
  • 2017 American Transplant Congress

    Renal Transplant Outcomes in Primary FSGS Compared with Other Recipients: A National Review of the Irish Transplant Registry.

    S. Cormican,1 C. Kennedy,1,2 P. O'Kelly,1 B. Doyle,3 A. Dorman,3 P. Conlon.1,2

    1Nephrology, Beaumont Hospital, Dublin, Ireland; 2Medicine, Royal College of Surgeons, Dublin, Ireland; 3Pathology, Beaumont Hospital, Dublin, Ireland

    Primary focal segmental glomerular sclerosis (p-FSGS) raises specific peri-transplant concerns, one of which is disease recurrence (r-FSGS). We aimed to compare transplant outcomes in patients…
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