Am J Transplant, Volume 17, Suppl 3 Archives - Page 123 of 181 - ATC Abstracts

2017 American Transplant Congress
Lymphoproliferative Disorders After Renal Transplantation Along Two Decades: A Large Longitudinal Study.
A. Franco,¹ D. Hernandez,² N. Maruri,³ A. Alonso,⁴ M. Crespo,⁵ A. Mazuecos,⁶ C. Diaz-Corte,⁷ M. Gentil.⁸
¹Nephrology, Hospital General, Alicante, Spain; ²Nephrology, Hospital Carlos Haya, Málaga, Spain; ³Nephrology, Hospital Cruces, Bilbao, Spain; ⁴Nephrology, Hospital Universitario, A Coruña, Spain; ⁵Nephrology, Hospital del Mar, Barcelona, Spain; ⁶Nephrology, Hospital Puerta del Mar, Cadiz, Spain; ⁷Nephrology, Hospital General, Oviedo, Spain; ⁸Nephrology, Hospital Virgen del Rocío, Sevilla, Spain
In a longuitudinal study,we evaluated the cumulative incidence of Posttransplant limphoproliferative disorders(PTLD),its relationship with Epstein Barr Virus (EBV),classical risk factors and outcome in 21546 single…
2017 American Transplant Congress
A Composite Score Associated with Spontaneous Operational Tolerance in Kidney Transplant Recipients.
R. Danger,¹ M. Chesneau,¹ C. Paul,¹ P. Guérif,¹ M. Durand,¹ K. Newell,² S. Kanaparthi,³ L. Turka,⁴ J.-P. Soulillou,¹ R. Houlgatte,⁵ M. Giral,^1,6 G. Ramstein,⁷ S. Brouard.^1,6
¹Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Université de Nantes, Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France; ²Department of Surgery, Emory University, Atlanta, GA; ³Immune Tolerance Network, Bethesda, MD; ⁴Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA; ⁵INSERM UMR 954,CHU de Nancy, DRCI, Nancy, France; ⁶CIC Biotherapy, CHU Nantes, Nantes, France; ⁷LINA DUKe, UMR 6241, Université de Nantes, Ecole des Mines de Nantes & CNRS, Nantes, France
New challenges in renal transplantation include using biological information to devise a useful clinical test for discerning high- and low-risk patients for individual therapy and…
2017 American Transplant Congress
Dendritic Cells That Highly Express SOCS1 Induce T-Cell Hypo-Responsiveness and Prolong Islet Allograft Survival.
R. Deng, X. Lu, M. Chen, Z. Xue, X. Zhang, J. Xu, L. Wu, Y. Ma.
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
The capability of dendritic cells (DCs) to induce an immune response or immune tolerance is dependent on their status. Suppressor of cytokine signaling 1 (SOCS1)…
2017 American Transplant Congress
Impact of Culture Expansion and Inflammatory Cytokine Challenge on DNA Methylation Profiles in MSC.
S. de Witte,¹ F. Peters,¹ A. Merino,¹ S. Korevaar,¹ S. Elliman,³ P. Newsome,² J. Meurs,¹ K. Boer,¹ C. Baan,¹ M. Hoogduijn.¹
¹Department of Internal Medicine, Erasmus MC, Rotterdam, Netherlands; ²Orbsen Therapeutics Ltd., Galway, Ireland; ³Department of NIHR Liver Biomedical Research Unit and Centre for Liver Research, University of Birmingham, Birmingham, United Kingdom
Mesenchymal stromal cells (MSC) are studied as possible immunotherapy after solid organ transplantation. However, to obtain sufficient numbers, cells need to be expanded in culture.…
2017 American Transplant Congress
Transcriptome Analysis of CD4-Lymphocyte Specifically Deleted of IKKbeta or NEMO in an Experimental Model of Rapid Progressive Glomerulonephritis (RPGN).
F. Thaiss,¹ J. Huang,² M. Chen,¹ H. Paust,¹ G. Zahner,¹ M. Alawi,² R. Geffers,³ L. Guo.¹
¹Nephrology, Univ. Hospital UKE, Hamburg, Germany; ²Bioinformatics, Univ. Hospital UKE, Hamburg, Germany; ³Genomics, Helmholtz Center Infection, Braunschweig, Germany
RPGN is T-cell mediated and can recur after kidney transplantation. T-cell receptor stimulation leads to intracellular signaling events ultimately causing activation of transcription factors such…
2017 American Transplant Congress
Imaging Cell Biology in Transplantation.
T. Ueno,¹ M. McGrath,¹ M. Yeung,¹ K. Jung,² Y. Kihara,³ O. Konno,³ Y. Nakamura,³ H. Iwamoto,³ S. Yun,² A. Chandraker.¹
¹Transplantation Research Center, Brighma and Women's Hospital, Harvard Medical School, Boston, MA; ²Department of Dermatology, Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA; ³Transplantation Surgery, Tokyo Medical University, Hachioji, Tokyo, Japan
Background: Following transplantation, a set of coordinated events occurs within the recipient immune system. Immature dendritic cells (DCs) migrate to sites of inflammation, become activated…
2017 American Transplant Congress
Direct Comparison of Hypothermic and Normothermic Organ Preservation in a Porcine Ex-Vivo Kidney Model.
N. Vallant,^1,2 B. Sandhu,¹ N. Wolfhagen,¹ C. Pusey,¹ V. Papalois.¹
¹Renal and Transplant Department, Imperial College, London, United Kingdom; ²Department of Visceral-, Transplant- and Thoracic Surgery, Medical University, Innsbruck, Austria
Background: Hypothermic machine perfusion is a well established method for deceased donor organ preservation as well as pre-transplant assessment and preconditioning. Recent translational and clinical…
2017 American Transplant Congress
Alloimmune Quiescence in Recipients with Long-Term Surviving Kidney Grafts.
K. Brown,¹ W. Baldwin,¹ E. Poggio,² W. Braun,² R. Fairchild.¹
¹Department of Immunology, Cleveland Clinic, Cleveland, OH; ²Nephrology and Glickman Urological Institue, Cleveland Clinic, Cleveland, OH
Recent studies of tolerant kidney transplant patients have identified increased numbers of circulating B cells expressing an immature/transitional phenotype (IgD+CD27-/IgD+CD27-CD24+CD38+). Similar frequencies of these immature/transitional…
2017 American Transplant Congress
One Year Outcomes of Low-Dose vs Very Low-Dose Extended-Release Tacrolimus/Mycophenolate mofetil in De Novo Kidney Transplantation: A Multi-Center Randomized Controlled Trial.
Y. Hidaka,¹ S. Yamanaga,¹ M. Toyoda,¹ S. Narumi,² Y. Watarai,² T. Kobayashi.³
¹Kidney Center, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan; ²Transplant Surgery, Japanese Red Cross Nagoya Daini Hospital, Nagoya, Aichi, Japan; ³Kidney Transplantation, Aichi Medical University, Nagoya, Aichi, Japan
Purpose: Once-daily tacrolimus extended-release formulation (TACER) has now been widely accepted in kidney transplant field. However, the optimal dosage for TACER is still not known.Patients…
2017 American Transplant Congress
Single-Center, Prospective, Open Label Pilot Study to Investigate the Effectiveness of Everolimus Associated with Mycophenolic Acid and Prednisone in Adult Patients Submitted to an Allograft Renal Transplant with Calcineurin Inhibitor Withdrawl on Week 16th.
L. Giordano,^1,2 M. Lasmar,^1,2 H. Vianna,^1,2 E. Lasmar.^1,2
¹Renal Transplant Unit, Hospital Universitário Ciências Médicas de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; ²Nephrology Department, Rede Mater Dei de Saúde, Belo Horizonte, Minas Gerais, Brazil
Although CI have proven efficacy in kidney transplantation worldwide, they are drugs with nephrotoxic potential and may contribute to chronic renal allograft nephropathy. As a…