ATC Abstracts

American Transplant Congress abstracts

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  • 2017 American Transplant Congress

    CD4+CD28null T Cells Require IL-15 & IL-21 to Become Alloresponsive.

    B. Dedeoglu, N. Litjens, R. Kraaijeveld, W. Verschoor, C. Baan, M. Betjes.

    Internal Medicine, Nephrology & Transplantation, Erasmus MC, University Medical Center, Rotterdam, Netherlands

    IntroductionAgeing and a pro-inflammatory milieu, such as present in patients with end-stage renal disease, are important drivers of increased T-cell differentiation, which is accompanied by…
  • 2017 American Transplant Congress

    CD19+CD38hiCD24hi Immature Transitional B Cells in PBMCs of Tolerant Kidney Recipients of Facilitating Cell-Enriched Hematopoietic Stem Cells and Renal Allografts.

    Y. Wen,1 A. Merchak,1 Y. Huang,1 H. Xu,1 L. Kahn,1 J. Leventhal,2 S. Ildstad.1

    1Institute for Cellular Therapeutics, University of Louisville, Louisville, KY; 2Comprehensive Transplant Center, Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL

    CD19+CD38hiCD24hi immature transitional B cells may represent a biomarker for transplantation tolerance in kidney transplant (KTx) recipients (Cherukuri A, et al. J Am Soc Nephrol.…
  • 2017 American Transplant Congress

    The Novel Establishment of Neuroma in Continuity Animal Model Based on Buccal Nerve in Rats.

    Y.-H. Hsieh,1,2 C.-J. Wen,1,3 C.-H. Lin,1,2,3,4 F.-C. Wei,1,2,3 Y.-C. Pei.3,5

    1Center for Vascularized Composite Allotransplantation, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 2Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 3College of Medicine, Chang Gung University, Taoyuan, Taiwan; 4Division of Trauma and Emergency Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 5Department of Physical Medicine & Rehabilitation, Chang Gung Memorial Hospital, Taoyuan, Taiwan

    Introduction: Peripheral nerve regeneration is a challenging and a rapid growing field. Its application is no longer restricted to trauma reconstruction but also in vascularized…
  • 2017 American Transplant Congress

    Life Confocal Imaging of Murine Liver Biopsies as Novel Tool to Assess Graft Viability Prior to Transplantation.

    R. Oberhuber, M. Fodor, B. Cardini, M. Maglione, M. Hermann, J. Troppmaier.

    Visceral, Transplant and Thoracic Surgery, Medical University Innsbruck, Innsbruck, Austria

    Prolonged ischemia time due to organ procurement and transport are main contributors to a decrease in organ quality, which is further enhanced during reperfusion. This…
  • 2017 American Transplant Congress

    Preservation Solution Affects the Immunological Milieu in Lung Transplantation and Alters the Inflammatory Balance.

    R. Bellmàs Sanz,1 M. Seyda,1 B. Wiegmann,2 C. Neudoerfl,1 A. Haverich,2,3 C. Falk,1,4 G. Warnecke.2,3

    1Institute of Transplant Immunology, IFB-Tx, Hannover Medical School, Hannover, Germany; 2Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany; 3German Center for Lung Research (DZL), Hannover, Germany; 4German Center for Infection Research (DZIF), Hannover, Germany

    Background: The pro-/ anti-inflammatory balance in lung transplantation is shaped by the pulmonary immune compartments, i.e. the T and NK cell repertoire. At present, it…
  • 2017 American Transplant Congress

    Deciphering the Mechanism of Remote Ischemic Preconditioning and Its Potential Benefits in Ischemia/Reperfusion Injury by Metabolomics.

    S. Cho, S.-I. Min, S.-Y. Kim, M.-J. Cho, W. Cho, S. Ahn, S.-K. Min, J. Ha.

    Surgery, Seoul National University Hospital, Seoul, Korea

    IntroductionRemote ischemic preconditioning (RIPC) is a strategy inducing resistance against ischemia and reperfusion(IR) injury. But the mechanism and the time window of protection representing RIPC…
  • 2017 American Transplant Congress

    Pre Transplant Donor Specific Antibodies and Clinical Outcomes in Kidney Transplant Recipient on Steroid Free Maintenance Immunosupression Regimen.

    O. Adebiyi,1 A. Sharfuddin,2 M. Yaqub,1 S. Hussain,1 D. Mishler,1 A. Sharfuddin,1 W. Goggins,1 T. Taber.1

    1Renal Transplant, Indiana University School of Medicine, Indianapolis, IN; 2Internal Medicine, Baqai University Hospital, Karachi, Pakistan

    Background: The clinical relevance of pre transplant donor specific antibodies has been reported in few clinical studies with respect to its effect on the risk…
  • 2017 American Transplant Congress

    A Novel Endpoint for Evaluating the Effect of Everolimus with Reduced Calcineurin Inhibitor on Long-Term Kidney Graft Outcome: The TRANSFORM Study Protocol.

    T. Srinivas,1 C. Legendre,1 F. Oppenheimer,1 H. Tedesco-Silva,1 W.-L. Luo,2 P. Bernhardt,2 C. Sommerer,1 S. Chadban,1 F. Vincenti,1 J. Pascual.1

    1TRANSFORM Study Group, Murray; 2Novartis Pharma AG, Basel, Switzerland

    Purpose: With the advancement of immunosuppressive (IS) agents, while short-term graft outcomes improved significantly, long-term outcomes remain a concern. Both acute rejection (AR) and nephrotoxicity…
  • 2017 American Transplant Congress

    Evaluation of the Conversion from Brand Name to Generic Immunosuppression in Hospitalized Organ Transplant Recipients.

    L. DeZotell,1 K. Blunck,1 J. Guy,1 M. Woods,1 M. Reffett,2 J. Terrell,2 A. Palermo,2 K. Gosch,3 L. Cummings.4

    1Department of Pharmacy, Saint Luke's Hospital, Kansas City, MO; 2Transplant Quality Department, Saint Luke's Hospital, Kansas City, MO; 3Cardiovascular Outcomes Research, Saint Luke's Hospital, Kansas City, MO; 4Abdominal Transplant and HPB Surgery, Saint Luke's Transplant Specialists, Kansas City, MO

    Purpose: Safe and effective immunosuppressant medications are critical to accomplish good graft and patient survival rates. The availability of “AB-rated” generic immunosuppression affords the opportunity…
  • 2017 American Transplant Congress

    Prediction of Renal Allograft Acute Rejection Using a Novel Non-Invasive Model Based on Acoustic Radiation Force Impulse.

    C. Yang,1 Y. Jin,2 S. Wu,3 T. Zhu,1 W. He.2

    1Urology, Zhongshan Hospital, Fudan University, Shanghai, China; 2Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, China; 3Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, China

    Point shear wave elastography (p-SWE) based on acoustic radiation force impulse (ARFI) is a novel technology to quantify tissue stiffness by measuring shear wave speed…
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