2017 American Transplant Congress
Predicting Immunologic Risk for Acute Rejection in Pediatric Liver Transplantation.
Yale University, New Haven, CT
Background: Studies in heart, lung, kidney, & liver transplantation (LT) indicate an increased negative impact of antibodies (Ab) to HLA on allograft outcome.Aim: To describe…2017 American Transplant Congress
Educational Strategies for Increased Wait-Listing Rates: Opportunities for Dialysis Center Intervention.
1UCLA, Los Angeles, CA; 2SLU, St. Louis, MO
Dialysis centers vary in how well they educate patients about kidney transplant (KT). This study categorized common groups of educational strategies used by dialysis staff;…2017 American Transplant Congress
Characterization of Human Plasma Cell Proteasome Adaptations to Proteasome Inhibitor Therapy: A Precision Medicine Approach to Overcome Drug Resistance in Desensitization.
1U of Cincinnati, Cincinnati, OH; 2Cincinnati Children's, Cincinnati, OH
Purpose: Bone marrow niche-resident plasma cells (BMNRPCs) exhibit variable sensitivity to proteasome inhibitor (PI) therapy. Here, we characterized alterations in the gene and protein expression…2017 American Transplant Congress
Causes and Long-Term Consequences of Diarrhea After Kidney Transplantation.
BackgroundThe causes and effects of diarrhea on graft outcomes have been poorly investigated in a large cohort of well-phenotyped kidney transplant recipients (KT). The epidemiological…2017 American Transplant Congress
MELD-Based Allocation Leads to Inferior Survival After Liver Transplantation.
Department of Surgery, Campus Virchow and Mitte, Charité-Universitätsmedizin Berlin, Berlin, Germany
Introduction and BackgroundThe MELD-based allocation system has been implemented in Germany in 2006 in order to decrease waiting list mortality in patients with end stage…2017 American Transplant Congress
Risk Factors for Post-Transplant Lymphoproliferative Disorders in Epstein-Barr Virus Mismatch Lung Transplant Recipients.
Brigham and Women's Hospital, Boston
Background: Post-transplant lymphoproliferative disorders (PTLD) are associated with significant morbidity and morality. Lung transplant patients appear to have higher rates of PTLD than other solid…2017 American Transplant Congress
Lessons Learned from Simultaneous Biopsies of Both Kidney and Pancreas Grafts in Recipients of Simultaneous Kidney-Pancreas Transplants.
University of Wisconsin, Madison
It is commonly assumed that in simultaneous kidney and pancreas (SPK) recipients the rejection of the two organs will be concordant. As a result, simultaneous…2017 American Transplant Congress
Regulation of T Cell Migration by Specifically Targeting Lymphotoxin β Receptor (LTβR)-Mediated Non-Canonical NFkB Signaling.
Background:Selective recruitment of regulatory T cells (Treg) to draining lymph nodes is crucial for graft survival, and LTαβ-LTβR signaling is required to direct Treg into…2017 American Transplant Congress
Induction of Delayed Renal Allograft Tolerance Using Only Clinically Available Reagents in Non-Human Primates.
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA
Background: We have previously reported successful induction of renal allograft tolerance following a period of conventional immunosuppression (Delayed tolerance) using nonmyeloablative conditioning that included anti-CD154…2017 American Transplant Congress
Validation of a Prediction Model for Cardiac Allograft Vasculopathy.
Cedars-Sinai Heart Institute, Los Angeles
Introduction: Cardiac allograft vasculopathy (CAV) continues to limit the long-term success of heart transplantation. Although the progression of CAV can be slowed by tailored immunosuppression,…
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