Am J Transplant, Volume 17, Suppl 3 Archives - Page 119 of 181 - ATC Abstracts

2017 American Transplant Congress
Achieving Ideal Outcome After Intestinal Transplantation: How Close Are We?
A. Ganoza,¹ N. Celik,¹ G. Bond,¹ K. Soltys,¹ J. Rudolph,² R. Sindhi,¹ G. Mazariegos.¹
¹Hillman Center for Pediatric Transplantation, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA; ²Intestinal Care and Rehabilitation Center, Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA
Aim:To determine the incidence of factors affecting ideal outcome after pediatric intestinal transplantation (ITx).Methods: Children that underwent primary ITx with intact grafts at one year…
2017 American Transplant Congress
High-Dose Acyclovir for Cytomegalovirus Prevention in Seropositive Solid Organ Transplant Recipients.
J. Fose,¹ E. McCreary,¹ M. Jorgenson,¹ M. Lucey,² J. Smith.²
¹Pharmacy, University of Wisconsin Hospital and Clinics, Madison, WI; ²Medicine, University of Wisconsin Hospital and Clinics, Madison, WI
Purpose: Evaluate the incidence of cytomegalovirus (CMV) infection in seropositive (R+) solid organ transplant recipients (SOT) receiving high-dose acyclovir (HD-A, 800 mg QID) prophylaxis.Methods: Retrospective…
2017 American Transplant Congress
Ambiguous Nucleic Acid Tests (NAT) Results – Case of a Donor with Intermittent HCV NAT(+) but No HCV Transmission.
M. Nowicki,^1,2 H. Prince,² C. Chinchilla,² C. De Los Santos,² J. Trageser,³ L. Stocks.³
¹Mendez National Institute of Transplantation Foundation, Los Angeles, CA; ²VRL-Eurofins, Los Angeles, CA; ³Lifesharing OPO, San Diego, CA
Background Less than 0.2 % of initially NAT(+) upon retesting are reported as NAT negative. However, there is a concern that these results could be…
2017 American Transplant Congress
Type-1 Interferon Impairs the Immunoregulatory Activity of IL-10: A Mechanism in the Abrogation of Transplant Tolerance.
M. Iglesias, A. Arun, B. Lam, W. Lee, G. Raimondi, G. Brandacher.
Plastic Surgery, Johns Hopkins University. School of Medicine, Baltimore, MD
PurposeA growing body of experimental evidence shows that engagement of toll like receptors (TLR) can abrogate or revert the tolerogenic effect of “costimulation blockade” in…
2017 American Transplant Congress
CMV-Specific CD4⁺ T Cells in CMV-IgG-Seronegative Individuals Protect from CMV Viremia Following Transplantation with a CMV-Seropositive Donor Kidney.
N. Litjens, L. Huang, B. Dedeoglu, R. Meijers, M. Betjes.
Internal Medicine, Nephrology and Transplantation, Erasmus Medical Center, Rotterdam, Netherlands
A primary infection with cytomegalovirus (CMV) is one of the major threats following transplantation of a CMV-IgG-seropositive donor organ into a CMV-IgG-seronegative individual. Therefore, prophylactic…
2017 American Transplant Congress
Persistent Donor Antigen Leads to Dysfunctional CD4⁺Memory T Cell Development.
M. Miller,¹ Y. Wang,¹ L. Chen,¹ Y. Lei,¹ M. Daniels,^2,3 E. Watkins,⁴ C. Mora Solano,² C. McIntosh,¹ N. Isaad,⁵ A. Chong,² M.-L. Alegre.¹
¹Medicine, University of Chicago, Chicago, IL; ²Surgery, University of Chicago, Chicago, IL; ³Chicago State University, Chicago, IL; ⁴Institute for Molecular Engineering, University of Chicago, Chicago, IL; ⁵Committee on Cancer Biology, University of Chicago, Chicago, IL
Tolerance to alloantigens is characterized by low alloreactive T cell responses upon restimulation with donor antigens, a state that can result from deletion of donor-specific…
2017 American Transplant Congress
The Inhibitory Effect of Plasma on T Cell Activation: Possible Role of Plasma Exchange in Anti Rejection Therapy.
A. Assounga,^1,2 S. Omarjee.¹
¹Dept Nephrology, University of KwaZulu-Natal, Durban, South Africa; ²Inkosi Albert Luthuli Central Hospital, Durban, South Africa
Reduction of lymphocyte proliferation by human plasma has been previously reported. Reduced activation of lymphocytes of patients on immunosuppressive drugs is well documented.Aim: To compare…
2017 American Transplant Congress
Outcome of Systemic Monitoring of DSA and Protocol Management to Optimize Renal Allograft Outcome in a Single Transplant Center.
S. Chang,¹ I. Mallawaarachchi,² C. Yip,¹ T. Shanahan,³ A. Gundroo,¹ A. Dwivedi,² S. Patel,⁴ M. Zachariah.¹
¹Internal Medicine, University of Buffalo, Buffalo, NY; ²Biomedical Sciences, Texas Tech University, El Paso, TX; ³IMMCO Diagnostics, Buffalo, NY; ⁴Surgery, University of Buffalo, Buffalo, NY
Denovo (dn) donor specific antibody (DSA) development has been shown to adversely affect long-term allograft survival. To improve graft outcome for kidney (K) transplant (Tx)…
2017 American Transplant Congress
Does HLA Class of Complement Activating Donor Specific Antibodies Matter: Single Centre Retrospective Analysis of Renal Allograft Outcomes.
A. Babu,^1,2,3 D. Briggs,³ D. Mitchell,¹ N. Krishnan,² R. Higgins,¹ S. Daga.^1,2,4
¹Warwick Medical School, University of Warwick, Coventry, United Kingdom; ²Nephrology and Transplantation, University Hospitals Coventrya and Warwickshire, Coventry, United Kingdom; ³Histocompatibility and Immunogenetics, NHS Blood and Transfusion, Birmingham, United Kingdom; ⁴Nephrology and Transplantation, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
Introduction. Complement activating donor specific antibodies may be associated with worse outcomes in a cohort of patients who have undergone HLA-AIT. We looked for differences…
2017 American Transplant Congress
Increased Pro-Inflammatory and Decreased Interferon-Related Gene Expression in Older as Compared with Younger Kidney Transplant Recipients.
J. Schaenman, O. Beiard, E. Liang, T. Sidwell, V. Groysberg, M. Rosetti, B. Abdalla, E. Lum, S. Bunnapradist, T. Pham, G. Dannovitch, J. Veale, H. Gritsch, A. Karlamangla, S. Cole, E. Reed.
David Geffen School of Medicine at UCLA, Los Angeles, CA
Older transplant recipients experience increased rates of death and infection as compared with younger patients. Our previous studies demonstrated increased frequency of terminally differentiated and…