ATC Abstracts

American Transplant Congress abstracts

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  • 2017 American Transplant Congress

    Just Keeps Getting Worse: Racial and Ethnic Disparities in Access to Live Donor Kidney Transplantation in the US Over the Last Twenty Years.

    T. Purnell,1 X. Luo,1 L. Kucirka,1 M. Henderson,1 E. Gordon,2 L. Boulware,3 D. Segev.1

    1Johns Hopkins University, Baltimore; 2Northwestern University, Chicago; 3Duke University, Durham

    Over the past two decades, there has been increased attention and efforts to reduce racial/ethnic disparities in access to live donor kidney transplantation (LDKT) in…
  • 2017 American Transplant Congress

    IgM Immunotherapy Restores Immune Homeostasis in Type 1 Diabetes.

    P. Chhabra,1 C. Wilson,2 D. Moore,2 K. Brayman.1

    1Surgery, University of Virginia, Charlottesville, VA; 2Pediatric Endocrinology, Vanderbilt University, Nashville, TN

    Goal: To determine the mechanism(s) by which IgM immunotherapy restores immune homeostasis in Type 1 Diabetes (T1D).Background: IgM immunotherapy prevents the onset and progression of…
  • 2017 American Transplant Congress

    FOXP3 rs3761548 A/C+A/A Genotype Is a Risk Factor for Steroid Resistant Rejection After Liver Transplantation.

    Y. Tanaka, V. Sapana, H. Ohdan.

    Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan

    (Introduction) Previous studies found that preferential accumulation of regulatory T (Treg) cells in the liver allografts during acute cellular rejection (ACR) was associated with less…
  • 2017 American Transplant Congress

    A Phase-Two, Randomised, Placebo-Controlled Trial: Belimumab in Renal Transplantation Targets Naïve, Activated Memory and Antibody Producing B Cells Whilst Sparing Regulatory B Cells.

    G. Banham,1,2 S. Flint,3 N. Torpey,2 P. Lyons,1 D. Shanahan,3 A. Gibson,3 A.-M. O'Sullivan,2 R. Jones,1,2,3 L. Devey,3 A. Richards,3 L. Erwig,3 C. Savage,3 K. Smith,1,2 R. Henderson,3 M. Clatworthy.1,2

    1Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom; 2Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom; 3GlaxoSmithKline, Stevenage, United Kingdom

    This phase 2, double-blind, randomised controlled study (BEL114424) explores the safety and potential efficacy of addition of belimumab to standard of care in renal transplantation…
  • 2017 American Transplant Congress

    U.S. Outcomes in Early Liver Transplantation for Alcoholic Hepatitis: Results from the American Consortium of Early Liver Transplantation for Alcoholic Hepatitis (ACCELERATE-AH).

    B. Lee,1 N. Mehta,1 L. Platt,2 G. Im,3 G. Therapondos,4 H. Han,5 D. Victor,6 D. Dronamraju,7 I. Hanouneh,8 M. Voigt,9 M. Rinella,10 S. Eswaran,11 J. Hause,11 C. Hsu,12 J. Dodge,1 Z. Li,2 N. Terrault.1

    1UCSF, SF; 2Johns Hopkins, Baltimore; 3Mt Sinai, NYC; 4Ochsner, New Orleans; 5USC, LA; 6Houston Methodist, Houston; 7Maryland, Baltimore; 8Cleveland Clinic, Cleveland; 9Iowa, Iowa City; 10Northwestern, Chicago; 11Rush, Chicago; 12UPenn, Philadelphia

    INTRODUCTIONA Franco-Belgian protocol showed that early liver transplant (LT) in severe alcoholic hepatitis (AH) could improve survival with low incidence of alcohol relapse (AR). Application…
  • 2017 American Transplant Congress

    Risk Factors and Consequences of De Novo Anti-HLA Donor Specific Antibodies in Kidney Transplant Recipients: The Force Awakens.

    B. Javaid, S. Rosen-Bronson, D. Li, M. Awwad, A. Gilbert, S. Ghasemian, J. Verbesey, P. Abrams, M. Grafals, J. Fenton, C. Cannon, J. Rapisura, J. Moore, M. Cooper.

    Kidney and Pancreas Transplant Program, MedStar Georgetown Transplant Institute, MedStar Georgetown University Hospital, Georgetown University School of Medicine, Washington, DC

    Background: Presence of anti-HLA donor specific antibodies (DSAs) has been associated with inferior kidney transplant outcomes. Identification of risk factors for de novo DSAs could…
  • 2017 American Transplant Congress

    Development of De Novo Donor Specific Antibodies (dnDSAs) Not the Presence of Pre-Transplant Donor Specific Antibodies (Pre-DSAs) Increase Rejection Risk in Crossmatch Negative Kidney Transplant Recipients.

    H. Khamash, L. Archambault, M. Buras, H. Kosiorek, M. Pando, K. Reddy, B. Kaplan, R. Heilman.

    Mayo Clinic Arizona, Phoenix, AZ

    Aim: Study the impact of Pre-DSAs on allograft outcomes in crossmatch negative kidney transplant recipients.Methods: Single center retrospective analysis of characteristics and outcomes of kidney…
  • 2017 American Transplant Congress

    Timing of Mesenchymal Stem Cell Infusions Affects Rejection Free and Overall Islet Allograft Survival.

    N. Kenyon,1 M. Willman,1 D. Han,1 A. Rabassa,1 W. Diaz,1 R. Leeman,1 K. McHenry,2 D. Salomon,3 A. Bartholomew,4 N. Kenyon,1 D. Berman.1

    1Diabetes Research Institute, University of Miami, Miami, FL; 2University of Illinois at Urbana-Champaign, Champaign, IL; 3The Scripps Research Institute, La Jolla, CA; 4University of Illinois at Chicago, Chicago, IL

    We recently demonstrated that autologous, bone marrow-derived mesenchymal stem cells (MSC) promote allogeneic islet engraftment and survival in a streptozotocin induced, cynomolgus monkey model of…
  • 2017 American Transplant Congress

    Assessing the Impact of the New KAS on Transplant Rates in Highly-HLA Sensitized (HS) Patients After Desensitization (Des) 2 Years Post Implementation.

    A. Vo,1 S. Williamson,1 K. Myers,1 E. Huang,1 J. Choi,1 X. Zhang,2 A. Peng,1 R. Najjar,1 S. Jordan.1

    1Kidney Transplant, Cedars-Sinai Medical Center, LA, CA; 2HLA Laboratory, Cedars-Sinai Medical Center, LA, CA

    Introduction: The new KAS aims to improve access to transplantation for HS patients, specifically CPRA 99-100%. Our center has extensive experience w. DES to improve…
  • 2017 American Transplant Congress

    Effect of Embolization History and Tumor Treatment Response on Plasma TGFβ in HCC Patients Listed for Liver Transplantation.

    P. Thevenot,1 K. Núñez,1 J. Gonzalez-Rosario,1 T. Sandow,1 A. Alharbi,1 A. Bokhari,1 D. Wyczechowska,2 A. Ochoa,2 A. Cohen.1

    1Multi-Organ Transplant Institute, Ochsner Health System, New Orleans, LA; 2Stanley S Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA

    Purpose: TGFβ signaling is an integral pathway in hepatocellular carcinoma (HCC) metastasis. In this study, we monitored TGFβ levels and imaging response in HCC patients…
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