2017 American Transplant Congress
Lymphotoxin (LT) β Receptor-Mediated Non-Classical NFκB Signaling in Lymphatic Endothelial Eells (LEC) is Required for Homeostatic T Cell Migration.
Background: The selective recruitment of regulatory T cells (Treg) or blockade of memory/effector T cell migration to the graft and draining lymph nodes (dLN) are…2017 American Transplant Congress
Graft-versus-Host Disease in Intestine Transplantation.
Surgery, Indiana University School of Medicine, Indianapolis, IN
PurposeThis study reports the incidence, location, and outcomes of graft-versus-host disease (GVHD) at an active intestine transplant center. Subgroup analysis is employed to assess for…2017 American Transplant Congress
CD4 Depletion Is Necessary and Sufficient for Long-Term Nonhuman Primate Xenotransplant Survival.
Introduction. Xenotransplantation may alleviate the organ shortage, yet experimental renal xenotransplant has met limited success. We have previously reported the longest surviving pig-to-nonhuman primate (NHP)…2017 American Transplant Congress
Just Keeps Getting Worse: Racial and Ethnic Disparities in Access to Live Donor Kidney Transplantation in the US Over the Last Twenty Years.
1Johns Hopkins University, Baltimore; 2Northwestern University, Chicago; 3Duke University, Durham
Over the past two decades, there has been increased attention and efforts to reduce racial/ethnic disparities in access to live donor kidney transplantation (LDKT) in…2017 American Transplant Congress
IgM Immunotherapy Restores Immune Homeostasis in Type 1 Diabetes.
Goal: To determine the mechanism(s) by which IgM immunotherapy restores immune homeostasis in Type 1 Diabetes (T1D).Background: IgM immunotherapy prevents the onset and progression of…2017 American Transplant Congress
FOXP3 rs3761548 A/C+A/A Genotype Is a Risk Factor for Steroid Resistant Rejection After Liver Transplantation.
Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan
(Introduction) Previous studies found that preferential accumulation of regulatory T (Treg) cells in the liver allografts during acute cellular rejection (ACR) was associated with less…2017 American Transplant Congress
A Phase-Two, Randomised, Placebo-Controlled Trial: Belimumab in Renal Transplantation Targets Naïve, Activated Memory and Antibody Producing B Cells Whilst Sparing Regulatory B Cells.
This phase 2, double-blind, randomised controlled study (BEL114424) explores the safety and potential efficacy of addition of belimumab to standard of care in renal transplantation…2017 American Transplant Congress
U.S. Outcomes in Early Liver Transplantation for Alcoholic Hepatitis: Results from the American Consortium of Early Liver Transplantation for Alcoholic Hepatitis (ACCELERATE-AH).
INTRODUCTIONA Franco-Belgian protocol showed that early liver transplant (LT) in severe alcoholic hepatitis (AH) could improve survival with low incidence of alcohol relapse (AR). Application…2017 American Transplant Congress
Risk Factors and Consequences of De Novo Anti-HLA Donor Specific Antibodies in Kidney Transplant Recipients: The Force Awakens.
Background: Presence of anti-HLA donor specific antibodies (DSAs) has been associated with inferior kidney transplant outcomes. Identification of risk factors for de novo DSAs could…2017 American Transplant Congress
Development of De Novo Donor Specific Antibodies (dnDSAs) Not the Presence of Pre-Transplant Donor Specific Antibodies (Pre-DSAs) Increase Rejection Risk in Crossmatch Negative Kidney Transplant Recipients.
Mayo Clinic Arizona, Phoenix, AZ
Aim: Study the impact of Pre-DSAs on allograft outcomes in crossmatch negative kidney transplant recipients.Methods: Single center retrospective analysis of characteristics and outcomes of kidney…
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