2017 American Transplant Congress
Baseline Immune Assessment to Individualize Immunosuppression in SPK Recipients with Type 1 Diabetes.
Introduction:Type 1 diabetes (T1D) is an immune-mediated disorder associated with multiple immunological anomalies. Immunologic abnormalities might help to explain why recipients of simultaneous pancreas kidney…2017 American Transplant Congress
Role of Donor-Derived Tissue Resident Memory T cells in Modulating Alloimmunity.
Emory Transplant Center, Emory University, Atlanta, GA
Recipient-derived, graft-specific memory T cells play a critical role in mediating allograft rejection, particularly in the setting of immunosuppression with costimulation blockade. Recently, it is…2017 American Transplant Congress
Induction of Mixed Chimerism to Prolong Liver Allograft Survival in Cynomolgus Monkeys.
CCTI, Columbia University, New York, NY
Purpose: Spontaneous liver tolerance occurs in highly selected patients with stable liver function. There is an unmet need for a safe and reliable regimen allowing…2017 American Transplant Congress
High Titer De Novo Donor-Specific HLA Alloantibodies and Cardiac Allograft Vasculopathy After Pediatric Heart Transplantation.
Background: Cardiac allograft vasculopathy (CAV) continues to be a limiting factor in long-term survival after pediatric heart transplantation (HT). Criteria for early diagnosis of CAV…2017 American Transplant Congress
Urinary Retention Associated with Polyomavirus (BK) Viruria and Higher Peak Blood BK Following Kidney Transplant (KTx).
BACKGROUND: BK nephropathy is a major risk factor for allograft dysfunction and loss. BK viruria and viremia are early markers of BK nephropathy in KTx…2017 American Transplant Congress
Impact of Cold Ischemia Time on Outcomes in Kidney Paired Donation (KPD).
1UWHealth, Madison; 2UMN, Minneapolis
Cold ischemic time (CIT) is an established risk factor for delayed graft function (DGF) in DD kidney tx. Impact of prolonged CIT, in the context…2017 American Transplant Congress
Differential Effects of the Novel ATP-Competitive mTOR Inhibitor (TORKinib) AZD2014 and Rapamycin on Alloimmunity and Transplant Survival.
Surgery, Thomas Starzl Transplantation Institute, Pittsburgh, PA
Background: Rapamycin (RAPA), is an immunosuppressive agent that inhibits the mechanistic target of Rapamycin (mTOR), the kinase subunit of two mTOR- containing complexes (mTORC1 and…2017 American Transplant Congress
Vendor to Center in 0-60: A Safe and Effective Blueprint for Creating an In-House On-Call System for Organ Offers.
Transplant, Medical University of South Carolina, Charleston, SC
Introduction: Our center returned to an in-house nurse coordinator on-call program 7/2016 after using a vendor from 11/2012 to 7/2016 for organ allocation. It was…2017 American Transplant Congress
Comprehensive Functional Assessment of the Pathogenic Potential of Immunodominant Donor Specific Antibody Following Treatment of Late Antibody Mediated Rejection or Mixed Acute Rejection.
1U of Cincinnati, Cincinnati; 2Christ Hospital, Cincinnati
HLA donor specific antibody (DSA) mediates injury by both complement dependent and independent mechanisms, including direct signaling via HLA antigens and via Fc receptor (FcR)…2017 American Transplant Congress
Impact of Bariatric Surgery on Risk of Organ Rejection Among Solid Organ Transplant Recipients.
Medicine, Northwestern University, Chicago, IL; Surgery, Northwestern University, Chicago, IL
Background: Obesity is a common condition that contributes to organ failure. Bariatric surgery is an effective surgical therapy for obesity and has been performed both…
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