ATC Abstracts

American Transplant Congress abstracts

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  • 2017 American Transplant Congress

    CMV Infection in Renal Transplant Recipients: Incidence and Efficacy of Prophylaxis According to Cytokine Single Nucleotide Polymorphisms.

    I. Perez-Flores, M. Moreno De La Higuera, N. Calvo Romero, B. Rodriguez Cubillo, A. Shabaka, M. Calvo Arevalo, V. Lopez De La Manzanara, A. Sanchez-Fructuoso.

    Nephrology, Hospital Clínico San Carlos, Madrid, Spain

    Objectives: To evaluate the influence of single nucleotide polymorphisms (SNP)of IL10, TNFα, IFNγand IL18 in the incidence of CMV infection in renal transplant recipients. Methods:…
  • 2017 American Transplant Congress

    Lack of Specificity of LC-MS/MS Based Urinary Biomarkers for Polyomavirus BK Nephropathy (BKPyVN).

    G. Zeng,1 L. Pan,2 Z. Lyu,2 Y. Huang,1 P. Randhawa.1

    1Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA; 2Departments of Nephrology & Pathology, Guangxi Medical University, Nanning, Guangxi, China

    Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) based studies have suggested that BKPyVN leads to the excretion of virus-specific urinary peptides which can serve as diagnostic markers…
  • 2017 American Transplant Congress

    Emerging Variables Which May Enhance Care of HIV Positive Renal Transplant Recipients.

    D. Leonard, M. Prendergast.

    Transplantation, Mayo Clinic, Jacksonville, FL

    Purpose: Single center experience of kidney and pancreas transplantation in the HIV positive populationMethods: Retrospective data and outcomes analysis of HIV positive kidney and pancreas…
  • 2017 American Transplant Congress

    Apoptotic Exosome-Like Vesicles Released During Tissue Injury Trigger IL23/IL-17 Autoimmune Axis and Accelerate Rejection.

    M. Dieudé,1,4 J. Turgeon,1,4 A. Karakeussian-Rimbault,1,4 L. Pomerleau,1 A. Robitaille,1 N. Grandvaux,1 É. Boilard,2,4 M.-J. Hébert.1,3,4

    1Research Centre, Centre Hospitalier de l'Université de Montréal, Montreal, Canada; 2CHU de Québec, Québec, Canada; 3Montreal University, Montreal, QC, Canada; 4Canadian National Transplantation Research Program, Edmonton, Canada

    Autoantibodies to apoptotic antigens, such as perlecan/LG3, are present pre-transplantation and contribute to organ rejection. We previously showed that during tissue injury, apoptotic endothelial cells…
  • 2017 American Transplant Congress

    Trafficking of Donor Leukocytes and Recipient Cells Cross-Dressed with Donor MHC Molecules After Transplantation of Cardiac Allografts in Monkeys.

    J. Marino, K. Robinson, J. Paster, I. Hanekamp, J. Madsen, G. Benichou.

    Center for Transplantation Sciences, Massachusetts General Hospital / Harvard Medical School, Boston, MA

    Activation of recipient T cells recognizing allogeneic MHC molecules displayed on donor leukocytes is known to trigger acute allograft rejection (direct allorecognition). Recently, we have…
  • 2017 American Transplant Congress

    HLA-DPA1 and HLA-DPB1 Frequencies in the US Populations.

    Z. Du, J. Patel, C. Braun, B. Norton.

    Pathology, Loyola University Medical Center, Maywood, IL

    Aim: HLA-DP antibodies can elicit positive crossmatches and be detrimental in organ transplantation. Although HLA-DP unacceptable antigens can be input in the UNOS database, they…
  • 2017 American Transplant Congress

    Integrative Analysis of ExomeSeq and Gene Expression Data for Identification of Novel Variants Associated with Antibody-Mediated Rejection in Kidney Transplant.

    S. Pineda,1,2 T. Sigdel,2 A. Jackson,3 M. Sirota,1,2 M. Sarwal.2

    1Institute for Computational Health Science, University of California, San Francisco (UCSF), San Francisco, CA; 2Department of Surgery, University of California, San Francisco (UCSF), University of California, San Francisco (UCSF), CA; 3Department of Medicine, Johns Hopkins, Baltimore, MD

    Background: The objective of this work is to characterize the impact of the donor-recipient (D/R) HLA and non-HLA mismatches on the risk of antibody-mediated rejection…
  • 2017 American Transplant Congress

    Association of Non-HLA Antibodies with Histological Changes of Antibody Mediated Injury in Kidney Transplantation.

    N. Leca,1 I. Gimferrer,2 P. Warner,2 K. Nelson,2 R. Bakthavatsalam,1 L. Sibulesy,1 B. Najafian,3 C. Robinson-Cohen,1 B. Kestenbaum.1

    1Division of Nephrology, University of Washington, Seattle; 2Bloodworks NW, Seattle

    Solid phase assays, particularly single-antigen beads, have substantially increased the sensitivity and accuracy of antibody detection in transplantation. However, donor specific antibodies(DSA) against human leukocyte…
  • 2017 American Transplant Congress

    Impact of Antibiotic Treatment Duration for Symptomatic Lower Urinary Tract Infections in Kidney Transplant Recipients.

    S. Shaikh, S. Tischer, D. Kaul, A. Naik, M. Miceli, K. Gregg, N. Leja, T. Patel.

    University of Michigan, Ann Arbor, MI

    Background: Urinary tract infections (UTIs) remain the most common infectious complication post kidney-transplantation and may cause significant morbidity and mortality. Treatment duration for symptomatic lower…
  • 2017 American Transplant Congress

    Strongyloides Infection in Solid Organ Transplant Recipients: A Single Center Experience and Review of the Literature.

    H. El Haddad,1 V. Hemmige,1 A. Sofjan,2 T. Lasco,3 A. Restrepo.1

    1Dept. of Medicine, Div. of Infectious Diseases, Baylor College of Medicine, Houston, TX; 2Univ. of Houston, College of Pharmacy, Houston, TX; 3CHI Baylor St Luke's Medical Center, Houston, TX

    Background: Solid Organ Transplant (SOT) recipients are at risk for Strongyloides stercoralis hyperinfection syndrome and disseminated disease. Most cases are caused by reactivation of latent…
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