Am J Transplant, Volume 17, Suppl 3 Archives - Page 113 of 181 - ATC Abstracts

2017 American Transplant Congress
The Impact of Hepatitis C Treatment on GFR and Immunosuppression in Renal Transplant Recipients.
J. Husson, R. Adekunle, B. Ravichandran, P. Mathur, S. Jonchhe, K. Stafford.
University of Maryland Medical Center, Baltimore, MD
Background: Renal transplant recipients (RTRs) with HCV are at an increased risk of graft rejection, making treatment of HCV in this population of the utmost…
2017 American Transplant Congress
Usefulness of Valacyclovir Prophylaxis for Preventing Cytomegalovirus Infection After Anti-Thymocyte Globulin Treatment as Antirejection Therapy.
E. Ko,^1,2 J. Yu,^1,2 B. Choi,^1,2 C. Park,^1,2 Y. Kim,^1,2 C. Yang,^1,2 B. Chung.^1,2
¹Transplant Research Center, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea; ²Division of Nephrology, Department of Internal Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea
Anti-thymocyte globulin (ATG) treatment for acute T-cell mediated rejection (TCMR) can increase the risk of CMV infection. We purposed to evaluate the effect of valacyclovir…
2017 American Transplant Congress
BKV Clearance Time Correlates with T-Cell Receptor Repertoire Shape and Exhaustion State of BKV-Specific T-Cells in Renal Transplant Patients with Severe BKV Infection.
U. Stervbo,^1,2 M. Nienen,¹ B. Weist,² P. Wehler,² T. Westhoff,¹ H.-D. Volk,² P. Reinke,² N. Babel.^1,2
¹Center for Translational Medicine, Medical Clinic I, Marienhospital Herne, University Hospital of the Ruhr-University Bochum, Bochum, Germany; ²Berlin-Brandenburg Center for Regenerative Therapies, Charité – University Medicine, Berlin, Germany
Reactivation of the BK polyomavirus is known to lead to severe complications in kidney transplant patients. The current treatment strategy relies on decreasing the immunosuppression…
2017 American Transplant Congress
Fate and Function of CD8+ T Cells Primed by Fetal Antigen During Pregnancy.
P. Porrett,¹ R. Xu,¹ E. Wherry.²
¹Surgery, University of Pennyslvania, Philadelphia, PA; ²Microbiology, University of Pennsylvania, Philadelphia, PA
Background The long-term fate of maternal T cells primed by fetal antigen during pregnancy has not been well studied but may have significant impact for…
2017 American Transplant Congress
Quantity and Functions of CD4^–CD8^– Double Negative (DN) αβ T Cells in Kidney Is MHC Dependent.
M. Sadasivam, S. Noel, S. Lee, A. Hamad, H. Rabb.
Johns Hopkins University, Baltimore, MD
Background: Prior studies have established important roles of CD4+ T cells, natural killer T cells, and CD4+CD25+FoxP3+ Tregs in kidney ischemia reperfusion injury (IRI) pathogenesis.…
2017 American Transplant Congress
Low Level Early Onset De Novo DSA's May Not Portend Early Graft Dysfunction in Kidney Transplant Recipients.
M. Abate, Y. Nigatu, B. Ryu, F. Darras, R. Jafrin, H. Suh, C. Estrada, E. Nord.
Nephrology and Hypertension, Stony Brook Medicine, Stony Brook, NY
Background: The occurrence of anti-HLA de novo DSA (dnDSA) has been associated with the histological features of antibody-mediated rejection (ABMR) on kidney biopsy. The significance…
2017 American Transplant Congress
Non-Donor-Specific Anti-HLA Antibodies Have an Adverse Impact in Kidney Graft Outcomes.
J. Malheiro,¹ S. Tafulo,² L. Dias,¹ L. Martins,¹ I. Beirão,¹ A. Castro-Henriques.¹
¹CHP, Porto, Portugal; ²IPST, Porto, Portugal
Few studies have studied the impact of non-donor-specific antibodies (NDSA) in kidney transplantation (KT), with most showing no impact of these antibodies. As antibody-mediated graft…
2017 American Transplant Congress
Clinical Experience with Novel Cephalosporin/Beta-Lactamase Inhibitor Combinations in the Treatment of Multidrug Resistant Pseudomonas aeruginosa and Carbapenem-Resistant Enterobacteriaceae in Solid Organ Transplant Recipients.
P. Nambiar,¹ K. Brizendine,¹ V. Athans,² E. Cober.¹
¹Infectious Disease, Cleveland Clinic Foundation, Cleveland; ²Pharmacy, Cleveland Clinic Foundation, Cleveland
Purpose: To review clinical outcomes in organ transplant recipients (OTRs) treated with Ceftazidime/avibactam (C/A) and ceftolozane/tazobactam (C/T) for infections caused by Multidrug resistant Pseudomonas aeruginosa…
2017 American Transplant Congress
AAV8 Delivery of TIMP-1 Prevents Hepatocyte Apoptosis After Liver Ischemia/Reperfusion Injury.
S. Duarte, P. Matian, M. Miller, R. Busuttil, A. Coito.
Dumont-UCLA Transplant Center, Los Angeles
Matrix metalloproteinase-9 (MMP-9) is a key mediator of leukocyte migration across vascular barriers in hepatic ischemia/reperfusion injury (IRI). Tissue inhibitor of metalloproteinase-1 (TIMP-1) is the…
2017 American Transplant Congress
Nuclear Co-Repressor Complex Inhibition Reverses Benefit of HDAC2 Deletion in Renal Ischemia.
D. Aufhauser Jr,¹ D. Murken,¹ Z. Wang,¹ A. Samanta,² G. Ge,¹ T. Bhatti,³ P. Cole,⁴ J. Kalin,⁴ W. Hancock,^2,3 M. Levine.^1,5
¹Surgery, University of Pennsylvania, Philadelphia, PA; ²Pathology, University of Pennsylvania, Philadelphia, PA; ³Pathology, Children's Hospital of Philadelphia, Philadelphia, PA; ⁴Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, MD; ⁵Surgery, Children's Hospital of Philadelphia, Philadelphia, PA
Introduction: Class I histone/protein deacetylases (HDACs) 1 and 2 bear >85% protein sequence homology and conventionally are thought to have similar function via occupancy in…