Am J Transplant, Volume 17, Suppl 3 Archives - Page 111 of 181 - ATC Abstracts

2017 American Transplant Congress
Binding of Antigens by Its Specific Antibodies Results in Exosome Formation Leading to Rejection of Syngeneic Murine Cardiac Grafts.
M. Sharma, W. Liu, M. Gunasekaran, S. Bansal, T. Mohanakumar.
Norton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix
Background: Antibody binding to its antigen can activate complement cascades leading to cell death. In addition, it can activate intracellular signals leading to rejection of…
2017 American Transplant Congress
The Unfunded OPTN/UNOS Mandate of Living Kidney Donor Follow-Up: Fewer Than 50% of Centers in Compliance.
M. Henderson, A. Thomas, A. Massie, X. Luo, A. Shaffer, C. Holscher, D. Segev.
Surgery, Johns Hopkins, Baltimore, MD
OPTN/UNOS began requiring 2-year living donor follow-up (LDF) in 2013. Current LDF, and changes associated with the new guidelines, have not been evaluated.METHODS: Using SRTR…
2017 American Transplant Congress
Immunodominant Donor Specific Antibody Reduction with Proteasome Inhibitor Based Treatment: Clinical Variability and Implications for Long Term Graft Survival.
A. Lichvar,¹ A. Leino,¹ S. Tremblay,¹ A. Shields,² B. Abu Jawdeh,¹ B. Hardy,¹ M. Anand,¹ M. Cuffy,¹ M. Cardi,¹ R. Alloway,¹ E. Woodle.¹
¹University of Cincinnati, Cincinnati; ²The Christ Hospital, Cincinnati
Proteasome inhibitor (PI) based regimens treat antibody mediated rejection (AMR) at least in part by eliminating donor specific antibody (DSA). iDSA response to PI-based therapy…
2017 American Transplant Congress
EPTS Is a Poor Predictor of Post-KT Mortality for Older Recipients.
M. McAdams DeMarco, X. Luo, A. Massie, D. Segev.
Johns Hopkins, Baltimore, MD
Background:The new kidney allocation system (KAS) is meant to better match longevity of recipients and allografts. The United Network for Organ Sharing (UNOS) decided that…
2017 American Transplant Congress
Effects of New KPD Histocompatibility Policy on Refusal Rate and Transplants.
R. Leishman,¹ M. Aeder,² M. Leffell,³ C. Murphey,⁴ N. Reinsmoen,⁵ S. Saidman,⁶ T. Sandholm,⁷ A. Toll,¹ A. Harper,¹ N. Turgeon.⁸
¹UNOS, Richmond, VA; ²Univ Hosp Med Ctr, Cleveland, OH; ³Johns Hopkins Univ, Baltimore, MD; ⁴SW Immunodiagnostics, San Antonio, TX; ⁵Cedars-Sinai Health, Los Angeles, CA; ⁶Mass Gen Hosp, Boston, MA; ⁷Carnegie Mellon Univ, Pittsburgh, PA; ⁸Emory Univ, Atlanta, GA
Background: Transplant centers commonly refuse kidney paired donation (KPD) match offers due to unacceptable crossmatch (XM). To reduce XM refusals a new OPTN KPD histocompatibility…
2017 American Transplant Congress
DNA Methylation Dynamics from Ischemia/Reperfusion Injury to Long-Term Allograft Function.
V. Bontha,¹ D. Maluf,¹ M. Dozmorov,² D. Bagchi,¹ K. Archer,³ V. Mas.¹
¹Surgery, UVA, Charlottesville; ²VCU, Richmond; ³OSU, Columbus
Background: We hypothesize that following early graft damage (e.g., ischemia reperfusion injury) post-kidney transplantation (KT), the graft response to injury and repair involve changes in…
2017 American Transplant Congress
Technical Refinement to Prevent Hepatic Outflow Disturbance in Right Lobe Living Donor Liver Transplantation: Simplified One-Orifice Venoplasty.
J. Kim, D. Choi.
Department of Surgery, Catholic University of Daegu College of Medicine, Daegu, Republic of Korea
Middle hepatic vein (MHV) reconstruction is often essential to avoid hepatic congestion and serious graft dysfunction in living donor liver transplantation (LDLT). The aim of…
2017 American Transplant Congress
Novel Cell Intrinsic Role of the Adaptor Protein TSAd in Maintaining Alloimmune T Regulatory Cell Function.
J. Wedel,^1,2 M. Stack,^1,2 T. Seto,^1,2 M. Sheehan,^1,2 K. Liu,^1,2 E. Flynn,^1,2 D. Briscoe.^1,2
¹Transplant Research Program, Boston Children's Hospital, Boston; ²Department of Pediatrics, Harvard Medical School, Boston
TSAd is an SH2 domain containing intracellular adapter molecule that functions to elicit T cell receptor-mediated signals and cytokine production. TSAd knockout (KO) T cells…
2017 American Transplant Congress
A Molecular Approach to Chronic Rejection: Antibody or T-Cell Mediated?
L. Kamal, P. O Broin, M. Lubetzky, Y. Bao, E. Akalin.
Montefiore Medical Center Transplant Center, Albert Einstein College of Medicine, NY
Despite the advances in diagnosis of chronic antibody-mediated rejection (CAMR), chronic T cell mediated rejection (CTCMR) is solely defined by Banff classification as chronic allograft…
2017 American Transplant Congress
Pregnancy After Kidney-Pancreas Transplantation: Maternal and Offspring Outcomes.
S. Rao,¹ L. Coscia,² D. Armenti,² S. Constantinescu,^1,2 M. Moritz.^2,3,4
¹Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA; ²Gift of Life Institute, Transplant Pregnancy Registry International, Philadelphia, PA; ³Surgery, Lehigh Valley Health Network, Allentown, PA; ⁴Morsani College of Medicine, USF, Tampa
This study analyzed 109 pregnancies (116 outcomes) in 62 female kidney-pancreas (KP) recipients reported to the Transplant Pregnancy Registry International (TPR). Data were collected via…