Am J Transplant, Volume 17, Suppl 3 Archives - Page 108 of 181 - ATC Abstracts

2017 American Transplant Congress
Novel Classification of Membranoproliferative Glomerulonephritis Pattern of Injury in Renal Allograft Based on Immunofluorescence Microscopy: Precise Diagnosis and Prognosis Analysis.
J. Wen, X. Li, M. Zhang, F. Xu, X. Ni, J. Chen, Z. Tang, Z. Liu.
National Clinical Research Center of Kidney Diseases, Jinling Hospital, Medical School of Nanjing University, Nanjing, China
Background: Membranoproliferative glomerulonephritis (MPGN) after renal transplantation is a pattern of injury with heterogenous etiologies. Novel classification of MPGN based on the Immunofluorescence microscopy was…
2017 American Transplant Congress
Use of Hepatitis C Infected Organs for Kidney Transplantation: A Cost-Effective Analysis.
B. Kiberd,¹ K. Doucette,² K. Tennankore.¹
¹Dalhousie University, Halifax, NS, Canada; ²University of Alberta, Edmonton, AB, Canada
Given that Hepatitis C (HCV) can be cured, organs from HCV+ deceased donors might be used even in HCV- recipients. However HCV treatment is expensive.…
2017 American Transplant Congress
Use of Forensic DNA Testing to Trace Unethical Organ Procurement and Organ Trafficking Practices.
M. He,^1,2 A. Corson,² Z. Wang,³ J. Russo,² T. Trey.²
¹Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO; ²Doctors Against Forced Organ Harvesting, Washington DC; ³World Organization To Investigate The Persecution of Falun Gong, New York, NY
The purpose of this study is to establish a methodology, which allows to identify evidence of transplant organs originating from Falun Gong prisoners of conscience…
2017 American Transplant Congress
Kidney Transplant Rejection Associated with DQ Eplet Mismatches.
S. Chakola,¹ P. Warner,² N. Andeen,³ B. Najafian,³ N. Leca,¹ C. Blosser.¹
¹Medicine, University of Washington, Seattle, WA; ²Bloodworks Northwest, Seattle, WA; ³Pathology, University of Washington, Seattle, WA
The presence of anti-HLA antibodies is associated with acute rejection, allograft dysfunction and earlier graft loss. HLA antibodies are recognized as being specific to these…
2017 American Transplant Congress
A Pretransplant Model Incorporating Serum Biomarkers Is Superior to the Milan Criteria in Stratifying Risk of Hepatocellular Carcinoma Recurrence Following Liver Transplantation: Analysis of 4407 Patients from the US Multicenter HCC Transplant Consortium.
V. Agopian, On Behalf of the US Multicenter HCC Transplant Consortium.
UCLA, LA
Objective: While adoption of the Milan Criteria (MC) has improved outcomes following liver transplantation (LT) for hepatocellular carcinoma (HCC), recurrence remains a significant challenge. We…
2017 American Transplant Congress
The Ultimate Calculated Panel Reactive Antibody Value Predicts Mortality After Heart Transplantation.
E. Kransdorf,¹ M. Kittleson,¹ J. Patel,¹ M. Pando,² L. Czer,¹ J. Kobashigawa.¹
¹Cedars-Sinai Heart Institute, Los Angeles; ²Mayo Clinic Arizona, Phoenix
Background: Sensitized heart transplant (HT) candidates are known to be at higher risk for adverse events after transplantation, including a positive crossmatch, rejection, and death.…
2017 American Transplant Congress
Shared Epitopes Contribute to Accumulation of Highly Sensitized Patients in Kidney Paired Donation Program.
S. Stepkowski, B. Mierzejewska, C. Baum, D. Bekbolsynov, R. Brunner, J. Kopke, S. Rees, M. Rees.
University of Toledo, Toledo, OH
Introduction: Kidney Paired Donation (KPD) programs suffer from the accumulation of highly sensitized patients. We evaluated the sensitization patterns in our KPD program-by comparison of…
2017 American Transplant Congress
Impact of Antihypertensive (AHT) Choice and Advagraf^® Dose on Interstitial Fibrosis/Tubular Atrophy (IF/TA) and IF/TA Progression in Renal Allografts 24 Months Post-Transplantation (Tx).
S. Cockfield,¹ D. Rush,² S. Wilson,³ J. Howell,⁴ FKC-014 Study Group.
¹University of Alberta Hospital, Edmonton, AB, Canada; ²Health Sciences Centre, Winnipeg, MB, Canada; ³Astellas Pharma Global Development, Northbrook, IL; ⁴Astellas Pharma Global Development, Markham, ON, Canada
IF/TA may be delayed using ACEi- or ARB-type AHTs, which target the renin-angiotensin system (RAS), as well as by optimizing tacrolimus (TAC) exposure. The effect…
2017 American Transplant Congress
Novel Personalized Immune-Monitoring Assay for Predicting Operational Tolerance by Using Humanized Mouse Model.
Y. Fukasaku,¹ R. Goto,¹ Y. Ganchiku,¹ M. Zaitsu,¹ M. Watanabe,¹ N. Kawamura,¹ Y. Koshizuka,¹ K. Yamashita,² T. Shimamura,³ A. Taketomi.¹
¹Gastroenterological Surgery I, Hokkaido University, Sapporo, Japan; ²Transplant Surgery, Hokkaido University, Sapporo, Japan; ³Division of Organ Transplantation, Hokkaido University, Sapporo, Japan
Background: Biomarkers and immune-monitoring assays predicting operational tolerance in transplant recipients have not been established. Our aim was to develop an immune-monitoring assay to address…
2017 American Transplant Congress
Preventing of Rejection of Vascularized Composite Allografts by Targeting T Cell Metabolism.
B. Oh,¹ C. Cheng,² G. Furtmüller,¹ W. Lee,¹ J. Powell,² G. Brandacher.¹
¹Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; ²Oncology, Johns Hopkins University School of Medicine, Baltimore, MD
[Background] Upon antigen recognition and co-stimulation, T lymphocytes upregulate the metabolic machinery necessary to proliferate and sustain effector function. This metabolic reprogramming in T cells…