2017 American Transplant Congress
Early and Late Antibody Mediated Rejection and Mixed Acute Rejection Are Clinically Distinct and Demonstrate Biologic Differences in Immunodominant Donor Specific Antibody Characteristics.
1U of Cincinnati, Cincinnati; 2The Christ Hospital, Cincinnati
Early and late antibody mediated rejection (AMR) and mixed acute rejection (MAR) possibly result from fundamentally different immunologic processes. DSA mediates direct injury by complement-dependent…2017 American Transplant Congress
Benefits of Induction in Recipients of Acute Renal Failure Donor Kidneys.
University of Michigan, Ann Arbor
Kidneys from donors with acute renal failure (ARF) are often discarded due to concerns for DGF and graft failure. Induction immunosuppression can be used to…2017 American Transplant Congress
Procurement Kidney Biopsy versus KDRI for Predicting Graft Survival.
Background: The kidney donor risk index (KDRI) incorporates 10 variables to match organ quality with expected recipient survival. Though controversial, procurement biopsies are often performed…2017 American Transplant Congress
Donor Batf3-Dependent Dendritic Cells Initiate Acute Rejection in a Skin Transplantation Model.
Donor skin dendritic cells (DCs) play a crucial role in providing allospecific signal to host T cells either by direct interaction of donor MHC with…2017 American Transplant Congress
Evaluation of Cytomegalovirus Prophylaxis Regimens in Intestinal Transplant Recipients: A Single Center Experience.
Purpose: To evaluate the incidence of cytomegalovirus (CMV) infection in intestinal transplant recipients after a change in an antiviral regimen.Methods: This was a retrospective review…2017 American Transplant Congress
IL-21R Antagonist Inhibits Differentiation of B Cells Towards Plasmablasts upon Alloantigen Stimulation.
Background: Antigen-specific antibody responses rely on IL-21+ T follicular helper (Tfh) cells that regulate B cell differentiation. In transplantation, a large proportion of renal allograft…2017 American Transplant Congress
At-Home Transplant Education Increases Black and Low-Income Dialysis Patients' Transplant Knowledge, Attitudes, Informed Decision-Making, and Pursuit: An Explore Transplant @ Home Randomized Controlled Trial.
1UCLA, Los Angeles, CA; 2Missouri Kidney Program, Columbia, MO
Black and low-income dialysis patients, who face greater barriers to kidney transplant (KT), may need additional educational support. This randomized controlled trial (RCT) assessed the…2017 American Transplant Congress
Optimization of Pancreatic Islet-Like Clusters from hiPSCs for Cell Therapy in Type 1 Diabetes.
Surgery, Beth Israel Deaconess Medical Center, Boston, MA
IntroductionTreatment for Type 1 Diabetes (T1D) includes pancreas or islets of Langerhans transplantation. Pancreatic beta-like cells from differentiated human induced pluripotent stem cells (hiPSCs) offer…2017 American Transplant Congress
Acute Cellular Rejection Is Associated with Increased Risk of Early and Late Graft Failure.
The association between acute cellular rejection and subsequent early and late graft loss has not been well-quantified.METHODS: Using SRTR data and Cox regression, we studied…2017 American Transplant Congress
Signal Inhibitory Regulatory Protein-α Regulates Pathologic Reactive Oxygen Species in Acute Kidney Injury.
Background: Ischemia reperfusion injury (IRI) is mediated by a complex cascade of pro-inflammatory and oxidative processes. We have reported that signal regulatory inhibitory protein (SIRP)-α…
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