Am J Transplant, Volume 17, Suppl 3 Archives - Page 105 of 181 - ATC Abstracts

2017 American Transplant Congress
Novel Cell Intrinsic Role of the Adaptor Protein TSAd in Maintaining Alloimmune T Regulatory Cell Function.
J. Wedel,^1,2 M. Stack,^1,2 T. Seto,^1,2 M. Sheehan,^1,2 K. Liu,^1,2 E. Flynn,^1,2 D. Briscoe.^1,2
¹Transplant Research Program, Boston Children's Hospital, Boston; ²Department of Pediatrics, Harvard Medical School, Boston
TSAd is an SH2 domain containing intracellular adapter molecule that functions to elicit T cell receptor-mediated signals and cytokine production. TSAd knockout (KO) T cells…
2017 American Transplant Congress
A Molecular Approach to Chronic Rejection: Antibody or T-Cell Mediated?
L. Kamal, P. O Broin, M. Lubetzky, Y. Bao, E. Akalin.
Montefiore Medical Center Transplant Center, Albert Einstein College of Medicine, NY
Despite the advances in diagnosis of chronic antibody-mediated rejection (CAMR), chronic T cell mediated rejection (CTCMR) is solely defined by Banff classification as chronic allograft…
2017 American Transplant Congress
Pregnancy After Kidney-Pancreas Transplantation: Maternal and Offspring Outcomes.
S. Rao,¹ L. Coscia,² D. Armenti,² S. Constantinescu,^1,2 M. Moritz.^2,3,4
¹Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA; ²Gift of Life Institute, Transplant Pregnancy Registry International, Philadelphia, PA; ³Surgery, Lehigh Valley Health Network, Allentown, PA; ⁴Morsani College of Medicine, USF, Tampa
This study analyzed 109 pregnancies (116 outcomes) in 62 female kidney-pancreas (KP) recipients reported to the Transplant Pregnancy Registry International (TPR). Data were collected via…
2017 American Transplant Congress
Effect of Hypothermic Pulsatile Machine Perfusion on Kidney Delayed Graft Function in Simultaneous Liver-Kidney Transplantation: A Single Center Study.
I. Korayem,¹ H. Gritsch,² J. Veale,² G. Lipshutz,² V. Agopian,¹ F. Kaldas,¹ D. Farmer,¹ R. Busuttil,¹ A. Zarrinpar.¹
¹Surgery, University of California, Los Angeles, CA; ²Urology, University of California, Los Angeles, CA
OBJECTIVE: Assessment of risk factors correlated with the development of kidney delayed graft function (kDGF) among recipients of simultaneous liver-kidney transplant (SLKT).BACKGROUND: Renal dysfunction occurs…
2017 American Transplant Congress
Aquaporin 4 Blockade Alters T Cell Anatomical Distribution and Prolongs Cardiac Allograft Survival in Sensitized Recipients.
M. Nicosia,¹ R. Fan,¹ G. Farr,² M. Pelletier,² P. McGuirk,² K. Ayasoufi,¹ A. Valujskikh.¹
¹Immunology, Cleveland Clinic, Cleveland; ²Aeromics, Inc., Cleveland
Aquaporins are water channels present on mammalian cells. We previously reported that aquaporin 4 (AQP4) blockade with small molecule inhibitor AER270/271 significantly prolongs survival of…
2017 American Transplant Congress
Ex Vivo Normothermic Perfusion of Isolated Segmental Porcine Bowel: A Novel Functional Model of the Small Intestine.
M. Hamed,¹ A. Barlow,¹ S. Khosla,¹ A. Sagar,¹ F. Gribble,² M. Murphy,³ G. Pettigrew,¹ E. Bolton,¹ J. Bradley,¹ M. Nicholson,¹ S. Hosgood,¹ K. Saeb-Parsy.¹
¹University Department of Surgery, Cambridge NIHR Biomedical Research Centre and NIHR Blood and Transplant Research Unit in Organ Donation and Transplantation, Cambridge, Cambridgeshire, United Kingdom; ²Wellcome Trust – MRC Institute of Metabolic Science, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom; ³MRC Mitochondrial Biology Unit, Cambridge, Cambridgeshire, United Kingdom
Introduction: There is a need for the development of suitable large animal models for research in gastroenterology and intestinal transplantation. Ex vivo normothermic perfusion (EVNP)…
2017 American Transplant Congress
Early Detection of Xenograft Rejection or Injury by Donor Derived Cell Free DNA in Pig to Baboon Cardiac Xenotransplantation.
A. Singh,¹ S. Agbor-Enoh,² J. Chan,¹ S. Groham,² P. Corcoran,¹ B. Lewis,³ M. Thomas,³ D. Ayares,⁴ K. Horvath,¹ H. Valantine,² M. Mohiuddin.¹
¹CSRP, NHLBI/NIH, Bethesda, MD; ²LTG, NHLBI/NIH, Bethesda, MD; ³ORS/NIH, Bethesda, MD; ⁴Revivicor, Inc, Blacksburg, VA
Detection of early graft rejection (EGR) is a great deal in the field of transplantation (Tx). A number of biomarkers have been used to determine…
2017 American Transplant Congress
Delayed Graft Function and Long-Term Graft Survival in DBD and DCD Kidney Recipients.
A. Massie, D. Segev.
JHU, Baltimore
Several single-center studies suggest that delayed graft function (DGF) is not associated with increased risk of graft loss in recipients of donation after cardiac death…
2017 American Transplant Congress
Islet Rejection in Autoimmune NOD Mouse Recipients: Implications for Stem Cell Therapies.
R. Gill,¹ M. Coulombe,¹ T. Kupfer,¹ K. Beard,¹ A. Burrack.²
¹Surgery and Immunology, University of Colorado Denver, Aurora, CO; ²University of Minnesota, Minneapolis, MN
Several efforts are ongoing to use stem cell precursors to generate islet-like tissues suitable for transplantation in autoimmune Type 1 diabetic (T1D) recipients. During the…
2017 American Transplant Congress
No Gains in Long-Term Survival Following Liver Transplantation Over the Past Three Decades.
A. Rana,¹ M. Kueht,¹ J. Moffett,¹ N. Galvan,¹ R. Cotton,¹ J. Vierling,^1,2 A. Mindikoglu,^1,2 C. O'Mahony,¹ J. Goss.¹
¹Surgery, Baylor College of Medicine, Houston; ²Hepatology, Baylor College of Medicine, Houston
It is widely reported that outcomes have steadily improved in liver transplantation over the past 3 decades. The national benchmark of 1-year survival is now…