2016 American Transplant Congress
Acute Inflammation, Chronic Damage and Renal Dysfunction in Renal Transplant Recipients with Delayed Graft Function (DGF).
Analysis of DGF and clinical outcomes in relation to progressive histological changes is not well reported. In this prospective longitudinal study, patients with DGF were…2016 American Transplant Congress
Non-adherence is associated with increased risk of rejection and graft loss.
1Medicine, MUSC, Charleston, SC; 2Surgery, MUSC, Charleston, SC.
Non-adherence is common among kidney transplant recipients. However, data on the impact of appointment and medication non-adherence on kidney transplant outcomes are scarce. This study…2016 American Transplant Congress
Validation of a Simplified Cost-Effective Clinical Risk Stratification That Predicts Myocardial Ischemic Events in Kidney Transplant Candidates.
Background: Diagnosis of coronary artery disease before kidney transplantation is crucial in decreasing morbidity and mortality & avoiding the need for angiography in kidney transplant…2016 American Transplant Congress
Seven Year Follow-Up of a Phase 2 Clinical Trial to Induce Tolerance in Living Donor Renal Transplant Recipients.
1Northwestern University, Chicago; 2University of Louisville, Louisville.
36 subjects have been enrolled and 31 transplanted in a phase 2 protocol (IDE 13947) to induce tolerance in recipients of living donor renal allografts…2016 American Transplant Congress
What Are the Charges and Costs of Transplanting High MELD Patients?
Transplant Surgery, NYU Langone Medical Center, New York, NY.
Purpose: There is a significant variation in the MELD scores and subsequent morbidity among liver recipients in the US. Larger OPOs consistently serve patients with…2016 American Transplant Congress
Pancreas Transplantation from Pediatric Donors: A UNOS Registry Analysis.
Division of Transplantation, University of Illinois at Chicago, Chicago.
Introduction: Major concerns about the utilization of pediatric pancreata are the cumulative islet mass and the increased technical complexity. The primary aim of this study…2016 American Transplant Congress
CD4 T Cell Mediated Help Is Required for Intra-Allograft Proliferation of Endogenous Memory CD8 T Cells and Their Ability to Mediate Rejection of Cardiac Allografts Subjected to Prolonged Ischemia.
Immunology, Cleveland Clinic, Cleveland, OH.
Memory T cells are critical components to protective immunity against recurrent pathogens, but memory T cells with donor-reactivity pose a major barrier to successful transplantation…2016 American Transplant Congress
A Risk Quantification Score for Heart Transplants: A Heart Donor Risk Index.
Background: To better risk stratify heart transplants, we developed a continuous heart donor risk index (HDRI) based on heart donors to quantify heart allograft failure.Methods:…2016 American Transplant Congress
DEPTOR Inhibits mTORC1 in CD4+ T Cells and Increases Treg Function by Stabilizing Foxp3 Expression.
The modulation of PI-3K/Akt-induced signaling is critical for CD4+ Treg homeostasis and stability. Moreover, activation of PI-3K/Akt/mTOR signals within T cell subsets is associated with…2016 American Transplant Congress
TGFb in Regulatory B Cells-Dependent Tolerance.
Surgery, Massachusetts General Hospital, Boston, MA.
In transplantation, increasing evidence support that B cells can play a major regulatory role in addition to their critical functions in allo-immunity and graft rejection.…
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