ATC Abstracts

American Transplant Congress abstracts

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  • 2016 American Transplant Congress

    Pharmacokinetic Evaluation of Astagraf XL® and Prograf® in Renal Transplant Candidates Following Laparoscopic Sleeve Gastrectomy.

    A. Lichvar,1 A. Leino,1 T. Kaiser,1 T. Mizuno,2 T. Fukuda,2 U. Christians,1 R. Alloway,1 A. Vinks,2 E. Woodle,1 T. Diwan.1

    1University of Cincinnati, Cincinnati; 2Cincinnati Children's Hospital, Cincinnati; 3University of Colorado, Denver.

    Purpose: The impact of laparoscopic sleeve gastrectomy (LGS) on immunosuppressive drug pharmacokinetics (PK) is unknown. The purpose of this study was to evaluate PK following…
  • 2016 American Transplant Congress

    Ureteroenterostomy in Kidney Transplant: Retrospective Analysis of 30 Consecutive Cases.

    H. Marinho Neto, B. Leslie, J. Neves Neto, M. Almeida, A. Pessoa, J. Offernni, M. Nogueira, S. Ximenes, W. Aguiar, H. Tedesco, J. Medina Pestana.

    Kidney Hospital, São Paulo, Brazil.

    INTRODUCTION: Lower urinary tract abnormalities are found in up to15% of adults and in 20-30% of children requiring kidney transplantation. Several will necessitate an enterocystoplasty…
  • 2016 American Transplant Congress

    Which Post-Transplant Complications Are More Common in Elderly Renal Recipients?

    F. Agena, F. Paula, B. Reichert, P. Neves, A. Piovesan, W. Nahas, E. David-Neto.

    Renal Transplantation Service, Hospital das Clinicas - University of Sao Paulo, Sao Paulo, Brazil.

    Elderly recipients are listed for renal transplantation (RTx) more frequently. The immediate (first 60 days) post-transplant complications expected in this group have not been well…
  • 2016 American Transplant Congress

    Risk Factors for the Development of CMV Viremia in a Cohort of Morbidly Obese Kidney Transplant Recipients Under Low Dose Valganciclovir Prophylaxis.

    J. Thielke,1 N. Jasiak,1 N. Hilal,1 S. Salah,1 E. Benedetti,2 P. West-Thielke.2

    1Pharmacy Practice, Univ of IL-Chicago Medical Center, Chicago, IL; 2Dept of Surgery, Univ of IL-Chicago Medical Center, Chicago, IL.

    Background: The rate of Cytomegalovirus infections in kidney transplant recipients drastically diminished with the advent of oral ganciclovir and subsequently valganciclovir. However it continues to…
  • 2016 American Transplant Congress

    Parameters of Uremia-Associated Premature Ageing of Peripheral T Cells Do Not Predict Infectious Complications After Renal Transplantation.

    B. Dedeoglu, R. Meijers, M. Klepper, D. Hesselink, C. Baan, N. Litjens, M. Betjes.

    Internal Medicine, Nephrology and Transplantation, Erasmus MC, University Medical Centre, Rotterdam, Netherlands.

    Background: End-stage renal disease (ESRD) patients have a prematurely aged T-cell system, which may contribute to the uremia-associated immune deficiency. In this study we tested…
  • 2016 American Transplant Congress

    C1q Assays Are Not Associated with Clinical or Serologic Endpoints.

    A. Gilbert,1 M. Zaheer,1 O. Timofeeva,2 M. Awwad,2 D. Li,2 S. Rosen-Bronson,2 B. Javaid,1 M. Grafals,1 J. Verbesey,1 P. Abrams,1 M. Cooper.1

    1Medicine, MedStar Georgetown Transplant Institute, Washington, DC; 2Pathology, MedStar Georgetown Transplant Institute, Washington, DC; 3Surgery, MedStar Georgetown Transplant Institute, Washington, DC.

    PURPOSE: The c1q assay has been proposed as a potential adjunct to standard donor specific antibody (DSA) testing designed to improve the specificity to identify…
  • 2016 American Transplant Congress

    Long Term Outcomes Following Antibody Mediated Rejection (AMR) in Renal Transplant Recipients.

    R. Crew, S. Patel, H. Morris, M. Chiles, L. Ratner.

    Columbia University, New York.

    INTRO: Progress in AMR treatment has improved early graft survival. Since the new kidney allocation system results in more sensitized patients getting transplanted, we expect…
  • 2016 American Transplant Congress

    Optimizing the Immunogenicity and Immunomodulatory Properties of MSC for Cellular Therapy.

    S. de Witte,1 M. Franquesa,1 T. Strini,1 S. Korevaar,1 F. Luk,1 S. Elliman,2 P. Newsome,3 M. Gargesha,4 D. Roy,4 A. Merino,1 C. Baan,1 M. Hoogduijn.1

    1ErasmusMC, Rotterdam, Netherlands; 2Orbsen Therapeutics, Galway, Ireland; 3University of Birmingham, Birmingham, United Kingdom; 4Bioinvision, Mayfield Village.

    Mesenchymal stromal cells (MSC) are candidates for immunotherapy after transplantation. MSC have shown to be immunomodulatory and low immunogenic, which is favorable for cellular therapy…
  • 2016 American Transplant Congress

    Tissue Priming of Plasmacytoid Dendritic Cells Enhances Their Phagocytosis and Lowers the Threshold for Subsequent Toll-Like Receptor 7/9 Activation.

    J. Ruben,1 G. Garcia-Romo,1 E. Breman,1 S. van der Kooij,1 A. Redeker,2 R. Arens,2 C. van Kooten.1

    1Nephrology, Leiden University Medical Centre, Leiden, Netherlands; 2Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, Netherlands.

    Plasmacytoid dendritic cells (pDC) have a pivotal role in clearing viral infections, and can regulate tolerance or immunity depending on their activation status. We have…
  • 2016 American Transplant Congress

    Hydrogen Sulphide Is an Important Regulator of Erythropoietin Synthesis in Patients with Anemia of Chronic Kidney Disease.

    J. Leigh,1 P. Shao,1 M. Saha,1 I. Lobb,1 A. Pasch,5 H. van Goor,4 M. Feelisch,2 R. Wang,3 A. Sener.1

    1Western University, London, Canada; 2University of Southhampton, Southhampton, United Kingdom; 3Lakehead University, Thunder Bay, Canada; 4University of Gronigen, Groningen, Netherlands; 5University Hospital Bern, Bern, Switzerland.

    Anemia affects 90% of hemodialysis patients and is a tremendous concern for patients and health care providers. CKD leads to chronic interstitial fibrosis which leads…
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