2016 American Transplant Congress
The Role of HLA Class II Antibody in Endothelial Cell Activation and Allograft Rejection.
Background: Antibody-mediated rejection is one of the major causes of chronic rejection. This is mediated by endothelial cell activation, a process of endothelium microvascular inflammation…2016 American Transplant Congress
Contributions of Naive vs. Endogenous and Induced Alloreactive Memory T Cells in Mixed Lymphocyte Reactions.
Surgery, MGH/Harvard Medical School, Boston, MA.
T lymphocytes isolated from naïve, unmanipulated mice, proliferate and secrete cytokines when cultured in vitro with allogeneic irradiated leukocytes. This in vitro response known as…2016 American Transplant Congress
Adiponectin Is Produced by Leukocytes Infiltrating Renal Transplants.
Immunology, Cleveland Clinic, Cleveland, OH.
Fat is now recognized as a source of immunologically significant cytokines. Adiponectin, the most abundant adipokine, is usually classified as an anti-inflammatory cytokine because decreased…2016 American Transplant Congress
Virtual Crossmatch in Simultaneous Pancreas-Kidney Transplant.
Background: Simultaneous pancreas-kidney transplant (SPKT) outcomes have improved over the years. Methods: Analyses of demographic data of patients submitted to SPKT from Dec/2000 to Sep/2015…2016 American Transplant Congress
MicroRNA-375 and -200c Are a Set of Novel Biomarkers That Can Predict Islet Autotransplantation Outcome.
Introduction: Total pancreatectomy with islet autotransplantation (TPIAT) is an effective treatment for refractive chronic pancreatitis to relieve pain and retain endocrine function. Patient selection is…2016 American Transplant Congress
Rapamycin (RPM) Synergizes with CD154 mAb and DST to Promote Long-Term Vascularized Composite Allograft (VCA) Survival, but Prevents Induction of Donor-Specific Tolerance.
Even though CD154 mAb (MR-1) plus donor splenocyte transfusion (DST) is very effective at inducing tolerance of various allografts, such as those of hearts, kidneys…2016 American Transplant Congress
Zero and One Mismathing for HLA DR10,14,16 Produces Increased Kidney Graft Survival.
Aims: HLA DR matching has shown measureable significant effects in kidney graft survival. Part and parcel of this association is the HLA Class II allele…2016 American Transplant Congress
Clinical Outcome of Elderly Living Kidney Donors: A Single-Center Study in Japan.
Urology, Tokyo Women's Medical University, Tokyo, Japan.
Background: Previous studies and current guidelines have suggested that elderly persons can be living kidney donors; however, reports on elderly donors >70 years old are…2016 American Transplant Congress
Comparison of Efficacy and Safety of a 4-Month Post-Renal Transplant Dose Reduction of Tacrolimus.
Introduction. The aim of the study was to determine the efficacy and safety balance of 2 different doses of tacrolimus extended-release (TacER) in kidney transplant…2016 American Transplant Congress
Comparison of Pharmacokinetic and Clinical Outcomes of Tacrolimus Hexal® with Prograf® Based Regimen in De Novo Kidney Transplant Recipients: Results from the Randomized, SparTacus Study.
1SparTacus Study Group, Cologne, Germany; 2Novartis Pharma GmbH, Nuernberg, Germany.
Background: There is very limited evidence on the pharmacokinetic (PK) and clinical outcomes, comparing a generic tacrolimus with the standard reference drug in transplant (Tx)…
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