ATC Abstracts

American Transplant Congress abstracts

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  • 2016 American Transplant Congress

    Type-I Interferon Induced Cross-Competition of IL-10 Signaling and Its Role in the Abrogation of Transplant Tolerance.

    M. Iglesias, A. Arun, W. Lee, G. Brandacher, G. Raimondi.

    Plastic Surgery, Johns Hopkins University, School of Medicine, Baltimore, MD.

    PurposeA growing body of evidence shows that induction of long term transplant survival by “costimulation blockade” (CoB) regimens is impaired by inflammatory responses. In particular,…
  • 2016 American Transplant Congress

    Pediatric Access to Kidney Transplantation Under KAS.

    W. Cherikh,1 D. Stewart,1 A. Kucheryavaya,1 M. Aeder,2 E. Brewer.3

    1UNOS, Richmond, VA; 2Univ. Hosp. Case Med Ctr, Cleveland, OH; 3Texas Children's Hosp/Baylor College Medicine, Houston, TX.

    Background. Under the kidney allocation system (KAS) implemented on Dec 4, 2014, pediatric (ped) priority is now based on Kidney Donor Profile Index (KDPI) <35%…
  • 2016 American Transplant Congress

    Offering HCV-Positive Kidneys to HCV-Negative Patients on the Kidney Transplant Waitlist Is Lifesaving: Results of a Markov Model.

    D. Goldberg, P. Reese, V. Potluri, F. Scott.

    Medicine, University of Pennsylvania, Philadelphia, PA.

    Background: Patients with ESRD on the transplant waitlist face substantial risks of dying without a transplant. Because 2/3 of kidneys from hepatitis C virus (HCV)-positive…
  • 2016 American Transplant Congress

    Immediate Introduction of Everolimus Does Not Affect Wound Healing and Delayed Graft Function in Kidney Transplant Recipients: 3-Months Results from NEVERWOUND Study.

    M. Carmellini,1 P. Todeschini,2 A. Secchi,3 S. Sandrini,4 E. Minetti,5 L. Furian,6 G. Spagnoletti,7 F. Pisani,8 G. Piredda,9 G. Cappelli,10 G. Tisone.11

    1AOU Senese, Siena, Italy; 2AOP S.Orsola-Malpighi, Bologna, Italy; 3Osp San Raffaele IRCCS, Milano, Italy; 4AO Spedali Civili, Brescia, Italy; 5AOU Careggi, Firenze, Italy; 6AOU di Padova, Padova, Italy; 7PU A.Gemelli, Roma, Italy; 8POU S.Salvatore, L'Aquila, Italy; 9AO G.Brotzu, Cagliari, Italy; 10AOUP di Modena, Modena, Italy; 11Fondazione PU Tor Vergata, Roma, Italy.

    The NEVERWOUND study was designed to evaluate the impact of immediate vs. delayed introduction of everolimus (EVR) on wound healing complications (WHC) and delayed graft…
  • 2016 American Transplant Congress

    Denosumab Prevents Bone Mineral Density Loss in De Novo Kidney Transplant Recipients: Results from a Randomized Controlled Trial.

    M. Bonani,1 D. Frey,2 J. Brockmann,3 T. Fehr,1 T. Müller,1 N. Graf,4 R. Wüthrich.1

    1Division of Nephrology, University Hospital Zurich, Zurich, Switzerland; 2Division of Rheumatology, University Hospital Zurich, Zurich, Switzerland; 3Division of Visceral and Transplantation Surgery, University Hospital Zurich, Zurich, Switzerland; 4Graf Biostatistics, Winterthur, Switzerland.

    Background: Kidney transplantation is associated with bone loss and an increased risk of fracture. Since current therapeutic options to prevent bone loss are limited we…
  • 2016 American Transplant Congress

    Associations of Risk Factors and Kidney Retransplant Outcomes Vary Between Three Common Induction Agents: Results from the Analysis of Over Ten-Thousand Cases in Ten Years.

    A. Santos, X. Wen, M. Casey, S. Rehman, K. Womer.

    Medicine, University of Florida, Gainesville, FL.

    BACKGROUND: There is no published study comparing the significance of risk factors for graft outcomes associated with common induction regimens combined with tacrolimus and mycophenolate…
  • 2016 American Transplant Congress

    Increasing Tacrolimus Time-in-Therapeutic Range Is Associated with Less Cellular Rejection in Lung Transplant Recipients.

    C. Ensor, K. Harrigan, R. Venkataramanan, M. Morrell, C. Moore, J. Hayanga, M. Crespo, J. DCunha, A. Zeevi, J. McDyer.

    University of Pittsburgh, Pittsburgh, PA.

    Purpose: To describe the effect of tacrolimus (FK) time-in-therapeutic range (TTR) on incidence of cellular rejection (ACR) within the first year after lung transplantation (LT).Methods:…
  • 2016 American Transplant Congress

    Serelaxin Decreases the Severity of Cold Ischemia-Reperfusion Injury After Liver Transplantation in Mice.

    S. Kageyama, K. Nakamura, R. Busuttil, J. Kupiec-Weglinski.

    The Dumont-UCLA Transplantation Center, UCLA, Los Angeles, CA.

    Background. Extended cold preservation contributes to ischemia-reperfusion injury (IRI), which impairs graft function and leads to poor clinical outcomes. Serelaxin (SER), a recombinant form of…
  • 2016 American Transplant Congress

    Prevalence of Polyreactive Innate-Like B Cells Among Graft-Infiltrating B Cells in Human Cardiac Allograft Vasculopathy.

    D. Chatterjee,1 C. Moore,2 B. Gao,3 K. Clerkin,1 S. See,1 D. Shaked,1 K. Rogers,1 S. Nunez,1 Y. Veras,1 L. Addonizio,1 M. Givertz,4 Y. Naka,1 D. Mancini,1 R. Vasilescu,5 C. Marboe,5 S. Restaino,1 J. Madsen,2 E. Zorn.1

    1Medicine, Columbia University Medical Center, NY, NY; 2Massachusetts General Hospital Transplant Center, Boston; 3First Hospital of Jilin University, Changchun, China; 4Brigham and Women's Hospital, Boston; 5Pathology & Cell Biology, Columbia University Medical Center, NY.

    Cardiac allograft vasculopathy (CAV) is a leading cause of death in long-term heart transplant survivors. Dense B cell infiltrates are common in heart transplants with…
  • 2016 American Transplant Congress

    Criteria for the Diagnosis of Microvascular Inflammation (MVI) in Kidney Transplant Biopsies (KTxBx).

    J. Grande,1 R. Leduc,2 The DeKAF Study Group.

    1Dept. of Lab Medicine & Pathology, Mayo Clinic College of Medicine, Rochester, MN; 2Division of Biostatistics, U. Minnesota School of Public Health, Minneapolis, MN.

    The presence of MVI (Banff glomerulitis "g" score and Banff peritubular capillary "ptc" score) in KTxBx, often related to antibody mediated rejection (AMR), is associated…
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