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American Transplant Congress abstracts

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  • 2016 American Transplant Congress

    The Apoptosis of the Tracheal Epithelia Increase the Recipient's MSCs Derived Myofibroblasts in Allografts to Exacerbate Obliterative Bronchiolitis After Tracheal Transplantation in Mice.

    C. Wang,1 T. Xia,1 X. Zhang,2 K. Jiang,1 J. Wang,1 J. Nie.1

    1Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuahn, Hubei, China; 2Department of Integrative Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuahn, Hubei, China.

    Background: The long-term outcome of lung transplantation is impeded by obliterative bronchiolitis (OB). However, the current treatment cannot effectively prevent the process of OB. The…
  • 2016 American Transplant Congress

    Pneumocystis Pneumonia Following Solid Organ Transplantation, Systematic Review and Meta-Analysis.

    S. Hosseini-Moghaddam,1,2 R. Krishnan.2

    1Medicine, Western University, London, ON, Canada; 2Epidemiology and Biostatistics, Western University, London, ON, Canada.

    Background: Different variables have been reported that may increase the risk of pneumocystis pneumonia (PCP) in solid organ transplant patients (SOT).Objectives:To investigate the effect of…
  • 2016 American Transplant Congress

    Increased Incidence of Clostridium difficile Infections with Proton Pump Inhibitor Use Post-Kidney Transplant.

    M. Spinner,1 K. Patel,1 E. Neuner,1 B. Stephany.2

    1Department of Pharmacy, Cleveland Clinic, Cleveland, OH; 2Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland, OH.

    Clostridium difficile infection (CDI) is often encountered in the solid-organ transplant patient population. The incidence in kidney transplant recipients ranges between 3.5-16%. There are CDI…
  • 2016 American Transplant Congress

    Tacrolimus Dosing, Trough Concentrations and Dose Adjustments Compared Between Two Generic Formulations in Adult Kidney Transplant Recipients.

    D. Taber, V. Phan, A. Wilton, N. Pilch, H. Meadows, J. Fleming, C. Mardis, A. Mardis, C. Bratton, K. Chavin, J. McGillicuddy, S. Nadig, P. Baliga.

    MUSC, Charleston, SC.

    Objective: The aim of this study was to assess if changing between two different formulations of generic tacrolimus ([tac] Mylan® and Dr. Reddy's Lab®) impacts…
  • 2016 American Transplant Congress

    Schisandra Sphenanthera Extract Facilitates Anti-Tuberculosis Treatment Post Renal Transplantation Through Increasing Bioavailability of Tacrolimus.

    R. Deng,1 L. Zhang,1 L. Liu,1 H. Fu,2 J. Li,1 Q. Fu,1 C. Wang.1

    1Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; 2Infectious Medicine Department, Guangzhou Infectious Disease Hospital, Guangzhou, China.

    Background: Hepatoprotective agent Schisandra sphenanthera extract (SchE) facilitates rifampicin-containing anti-tuberculosis (TB) chemotherapy by stabilizing the Tacrolimus (FK506) blood concentration through increasing the oral bioavailability, which…
  • 2016 American Transplant Congress

    Differences in Reported Barriers to Immunosuppression Adherence Among a Cohort of Pediatric Renal Transplant Recipients from the United States and Canada.

    O. Bignall II,1,2 A. Pai,2 S. Amaral,3 S. Furth,3 N. Bergman,2 J. Goebel,4 The TAKE-IT Study Investigators, B. Foster.5

    1Nephrology and Hypertension, Cincinnati Children's Hospital, Cincinnati, OH; 2Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital, Cincinnati, OH; 3Nephrology, The Children's Hospital of Philadelphia, Philadelphia, PA; 4Nephrology, Children's Hospital of Colorado, Aurora, CO; 5Nephrology, Montreal Children's Hospital, Montreal, QC, Canada.

    Aim: The purpose of this study was to examine differences in reported barriers to immunosuppressant adherence (IA) between a cohort of pediatric renal transplant recipients…
  • 2016 American Transplant Congress

    A Retrospective Analysis of Rabbit Antithymocyte Globulin Dosing, MELD, Race, and Weight on Infection and Rejection Rates in Liver Transplantation.

    R. Imai, U. Wang.

    Department of Pharmacy, Stanford Health Care, Stanford, CA.

    INTRODUCTION: Rabbit antithymocyte globulin (rATG) use in liver transplantation is uncommon. At our center, induction therapy is comprised of rATG dosed at 1 – 2…
  • 2016 American Transplant Congress

    Ideal Outcome After Liver Transplantation: An Exploratory Study Using Machine Learning Analyses to Leverage Long-Term Registry Data from Studies in Pediatric Liver Transplantation (SPLIT).

    E. Hsu,1 M. Shaffer,1,2 R. Anand,3 V. Ng,4 J. Bucuvalas.5

    1University of Washington School of Medicine, Seattle, WA; 2Children's Core for Biomedical Statistics, Center for Clinical and Translational Research, Seattle Children's Hospital, Seattle, WA; 3The EMMES Corporation, Rockville, MD; 4The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada; 5Cincinnati Children's Hospital and Medical Center, Cincinnati, OH.

    We analyzed the Studies in Pediatric Liver Transplantation (SPLIT) registry dataset using heat map and random forests analyses (RFA) to determine if ideal outcome (IO)…
  • 2016 American Transplant Congress

    Liver Transplantation for Propionic Acidemia: A Review of the United States Scientific Registry for Transplant Recipients (SRTR) and Non-US Case Series.

    N. Celik, K. Soltys, G. Bond, Q. Sun, G. Vockley, R. Sindhi, G. Mazariegos.

    Surgery, Childrens Hospital of Pgh, Pittsburgh.

    Background: A fifth of all pediatric liver transplants in the US are performed for metabolic disease. Propionic acidemia, an autosomal recessive branched chain organic acidemia…
  • 2016 American Transplant Congress

    Increased Gene Expression of TGF-β in Peripheral Blood Mononuclear Cells from Renal Transplant Patients with Polyomavirus BK Viremi.

    W. Yin,1 M. Lu.2

    1Surgery, School of Medicine, Tzu Chi University, Hualien, Taiwan, Division of General Surgery, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chia-I, Dalin, Taiwan; 2Allergy, Immunology and Rheumatology, School of Medicine, Tzu Chi University, Hualien, Taiwan, Division of Allergy, Immunology and Rheumatology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chia-I, Dalin, Taiwan.

    We aimed to investigate the roles of cytokines during polyomavirus BK (BKV) reactivation in renal transplant patients. Forty-eight renal allograft recipients were enrolled in this…
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