Am J Transplant, Volume 16, Suppl 3 Archives - Page 67 of 180 - ATC Abstracts

2016 American Transplant Congress
Impact of Proximity MELD/PELD Points on Liver Redistricting Scenarios.
S. Gentry,^1,2 J. Pyke,¹ D. Schladt,¹ J. Zeglin,¹ W. Kim,³ J. Lake,⁴ R. Hirose,⁵ D. Mulligan,⁶ A. Israni.¹
¹Scientific Registry of Transplant Recipients, Minneapolis; ²United States Naval Academy, Annapolis; ³Stanford, Palo Alto; ⁴University of Minnesota, Minneapolis; ⁵Surgery, University of California, San Francisco; ⁶Surgery, Yale University, New Haven.
Background: To address geographic disparity in liver allocation, a new organ distribution system consisting of 4 or 8 districts has been proposed (Gentry, Am J…
2016 American Transplant Congress
The “PHS Increased Risk” Label Is Associated with Non-Utilization of Hundreds of Organs Per Year.
M. Volk,¹ A. Wilk,² C. Wolfe,³ D. Kaul.⁴
¹Transplantation Institute, Loma Linda University, Loma Linda, CA; ²United Network for Organ Sharing, Richmond, VA; ³Division of Infectious Diseases, Duke University, Durham, NC; ⁴Division of Infectious Diseases, University of Michigan, Ann Arbor, MI.
The Public Health Service (PHS) guidelines use behavioral risk factors to designate certain organ donors as carrying increased risk for the transmission of hepatitis B,…
2016 American Transplant Congress
One Year Post VZV Booster: Still Equal Response in Renal Transplant Recipients Compared to Healthy Persons.
M. Kho,¹ W. Weimar,¹ M. Boer-Verschragen,¹ A. van der Eijk,² N. van Besouw.¹
¹Internal Medicine - Nephrology and Transplantation, Erasmus Medical Center, Rotterdam, Netherlands; ²Viroscience, Erasmus Medical Center, Rotterdam, Netherlands.
Introduction: Herpes zoster occurs more frequently and with more complications in solid organ transplant recipients than in age matched healthy persons. Vaccination could prevent herpes…
2016 American Transplant Congress
The Quilty Effect in Pediatric Heart Transplant Recipients.
A. Joong,¹ M. Richmond,¹ K. Stack,² R. Rodriguez,¹ J. McAllister,² W. Zuckerman,¹ T. Lee,¹ S. Law,¹ L. Addonizio.¹
¹Pediatric Cardiology, Columbia University, New York, NY; ²Surgery, Columbia University, New York, NY.
Purpose: The Quilty effect is defined as the presence of a nodular endocardial infiltrate of lymphocytes in an endomyocardial biopsy (EMB), and has been described…
2016 American Transplant Congress
IL-2 Therapy Restores the Impaired Function of Regulatory T Cells Induced by Calcineurin Inhibitors in Liver Transplantation.
G. Whitehouse, E. Gray, S. Mastoridis, E. Kodela, A. Sanchez-Fueyo, M. Martinez-Llordella.
Liver Science Department, King's College London, London, United Kingdom.
CD4+CD25+FOXP3+ regulatory T cells (Tregs) have an essential role in immune regulation and constitute a key target for cellular immunotherapies in transplantation. IL-2 is critical…
2016 American Transplant Congress
Long-Lasting Skin Allograft Tolerance Induced and Maintained by Short-Term Vascularized Bone Marrow Transplant in a Mouse Model.
C.-H. Lin,¹ M. Anggelia,¹ H.-Y. Cheng,¹ Y.-L. Wang,¹ W.-Y. Chuang,¹ C.-H. Lin,¹ G. Brandacher.²
¹Center for Vascularized Composite Allotransplantation, Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan; ²Department of Plastic and Reconstructive Surgery, Vascularized Composite Allotransplantation (VCA) Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD.
Background: Accumulating evidences indicate that vascularized bone marrow transplantation (VBMT) plays a critical role in inducing tolerance of vascularized composite allografts (VCA). Recipients with long-term…
2016 American Transplant Congress
Targeting IFN-g-Expressing TIM-4⁺B Effector (Beff) Cells as a Novel Strategy to Prevent Allograft Rejection.
Q. Ding,¹ K. Mohib,¹ S. Xiao,² V. Kuchroo,² D. Rothstein.¹
¹University of Pittsburgh, Pittsburgh; ²Harvard Medical School, Boston.
B cell depletion can augment or inhibit auto- and allo- immune responses in humans and mice without altering Ig levels. This is likely due to…
2016 American Transplant Congress
Mechanistic Insights into How Targeting of HDAC10 Promotes Foxp3+ Treg Cell Suppressive Activity, Gene Expression and Metabolism, and Enhances Allograft Survival.
S. Dahiya,¹ L. Wang,¹ U. Beier,^1,2 A. Angelin,¹ R. Han,¹ D. Wallace,^1,2 W. Hancock.^1,2
¹Children's Hospital of Philadelphia, Philadelphia; ²University of Pennsylvania, Philadelphia.
Foxp3+ T-regulatory (Treg) cells are key regulators of immune responses that can result in unwarranted inflammation and promote allograft rejection. From a theoretical perspective, targeting…
2016 American Transplant Congress
Characteristics and Outcomes of Vancomycin Resistant Enterococcus Bacteremia After Liver Transplant.
R. Odrobina,¹ C. Kovacs,¹ R. Butler,² C. Koval.¹
¹Department of Infectious Diseases, Cleveland Clinic, Cleveland, OH; ²Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH.
Vancomycin Resistant Enterococcus (VRE) infection is reported in 5-20% of liver transplant (LT) recipients and is associated with decreased survival. Published data includes infections of…
2016 American Transplant Congress
Biliary Epithelial Damage, Regenerative Capacity and Local Immune Response After Cold Storage of DBD Livers Determine Biliary Complications After Liver Transplantation.
S. Brunner, H. Junger, H. Schlitt, S. Fichtner-Feigl.
Department of Surgery, University Medical Center Regensburg, Regensburg, Germany.
Background: The aim of this study was to examine the development and molecular mechanisms of bile duct (BD) damage between organ retrieval and transplantation and…