Am J Transplant, Volume 16, Suppl 3 Archives - Page 67 of 180 - ATC Abstracts

2016 American Transplant Congress
Cytometric Deep Profiling of the CD8+ T-Cell Compartment in Transplant Patients with CMV Viremia.
V. Ferreira, D. Kumar, S. Husain, M. Bhat, P. Ashton, A. Humar.
UHN, Toronto, Canada.
Background: Cytomegalovirus (CMV) infection is a common opportunistic viral infection in transplant patients. Patterns of viremia and relapse are influenced by the host immune response,…
2016 American Transplant Congress
Intracellular OPN Is an Essential Protective Factor for Cardiac Endothelial Cell and the Long Term Heart Graft Survival.
Y. Su,^1,2,3 Z.-X. Zhang,^1,2,3 Z.-Q. Yin,¹ X.-Y. Huang,¹ A. Jevnikar.^1,2,3,4
¹Matthew Mailing Centre for Translational Transplantation Studies, Lawson Health Research Institute, London Health Sciences Centre, London Health Sciences Centre, Lodon, ON, Canada; ²Departments of Medicine, London Health Sciences Centre, Lodon, ON, Canada; ³Departments of Pathology, London Health Sciences Centre, London, ON, Canada.
[Background] Endothelial cell (EC) injury is central to cardiac allograft vasculopathy and premature graft loss. Osteopontin (OPN) is a multifunctional anti-apoptotic protein that is involved…
2016 American Transplant Congress
Rapamycin Encapsulated Nanoparticles as Pre-Treatment in Lung Transplantation.
G. Bazzle,¹ S. Dixit,² K. Patel,³ A.-M. Broome,² S. Nadig,^1,3 C. Atkinson.^1,3
¹Microbiology and Immunology, Medical University of South Carolina, Charleston, SC; ²Department of Radiology, Medical University of South Carolina, Charleston, SC; ³Department of Surgery, Medical University of South Carolina, Charleston, SC.
Introduction: While short-term lung transplant outcomes have improved over the years, long-term survival rates remain stagnant. Many injuries occur to the donor organ before transplantation,…
2016 American Transplant Congress
B Lymphocytes Prevent Transplantation Tolerance in NOD Mice by Limiting CD4 Treg Function.
B. Stocks, C. Wilson, D. Meehan, A. Marshall, D. Moore.
Pediatrics, Vanderbilt University, Nashville, TN.
IntroductionType 1 Diabetes is a significant barrier to islet transplant as grafts are subject to both alloimmunity and recurrent autoimmunity. No better is this clinical…
2016 American Transplant Congress
Thymus Is Required for T Cells Reconstitution Following Antibody-Mediated Lymphoablation.
K. Ayasoufi, R. Fan, A. Valujskikh.
Cleveland Clinic, Cleveland.
Antibody-mediated lymphocyte depletion is used as induction therapy in sensitized transplant recipients. Following lymphoablation, peripheral lymphopenia triggers homeostatic T cell proliferation (HP) and enhanced thymopoiesis.…
2016 American Transplant Congress
Prospective Randomized OPEN Trial Designed to Reduce the Incidence of Cytomegalovirus (CMV) Infection in DE NOVO Kidney Transplant Recipients Two-Year Results.
R. Esmeraldo, M. Oliveira, P. Pinheiro, C. Girao, T. Freitas.
Transplant, Hospital Geral de Fortaleza, Fortaleza, CE, Brazil.
Introduction: CMV infection is a frequent complication following organ transplantation, and is associated with inferior long-term patient and graft survival. Here we report the results…
2016 American Transplant Congress
Non-Invasive Biomarkers for Graft Quality and Outcome Post-Liver Transplantation.
R. Gehrau, V. Mas, S. Bontha, D. Maluf.
Surgery, UVA, Charlottesville, VA.
Background: Graft quality is a determinant of graft function after liver transplantation (LT). This study aimed to evaluate graft molecular markers that correlate to peripheral…
2016 American Transplant Congress
Defective Post-Reperfusion Metabolic Recovery Directly Associates with Incident Delayed Graft Function.
L. Wijermars, A. Schaapherder, J. Lindeman.
Department of Surgery, Leiden University Medical Center, Leiden, Netherlands.
Delayed graft function (DGF) following kidney transplantation detrimentally affects long-term graft function and survival. DGF is a manifestation of ischemia reperfusion (I/R) injury, yet up…
2016 American Transplant Congress
Evaluation of the Long-Term Outcomes with Everolimus After Calcineurin Inhibitor Withdrawal: 36M Results of the H2304 and PROTECT Extension Studies.
L. Fischer,^1,2 J. Fung,¹ H. Metselaar,¹ G. Kaiser,^1,2 P. Schemmer,² P. Neuhaus,² G. Dong,³ P. Lopez,⁴ P. Bernhardt,⁴ H. Schlitt.²
¹H2304 study group, Hamburg, Germany; ²PROTECT study group, Hamburg, Germany; ³Novartis Pharmaceuticals Corporation, East Hanover, NJ; ⁴Novartis Pharma AG, Basel, Switzerland.
Background: The H2304 and PROTECT studies demonstrated reduced nephrotoxicity with everolimus (EVR)-based calcineurin inhibitor (CNI; cyclosporine: CsA, tacrolimus: TAC)-free regimens at Month (M) 12. Here,…
2016 American Transplant Congress
Pregnancy Excludes Women from Successful Living Donor Transplantation.
P. Porrett,¹ B. Bromberger,² S. Hashmi,¹ A. Morrison,¹ D. Sawinski.³
¹Surgery, University of Pennsylvania, Philadelphia, PA; ²Surgery, Columbia University, New York, NY; ³Medicine, University of Pennsylvania, Philadelphia, PA.
INTRODUCTION Pregnancy-induced sensitization (PIS) is a barrier to the transplantation of women and contributes significantly to gender disparity in transplantation. We hypothesized that this barrier…