Am J Transplant, Volume 16, Suppl 3 Archives - Page 62 of 180 - ATC Abstracts

2016 American Transplant Congress
Impact of Sarcopenia in Overweight/Obese Recipients on the Outcomes After Adult Living Donor Liver Transplantation.
A. Hammad,^1,2 Y. Hamaguchi,² S. Okumura,² A. Kobayashi,² S. Yagi,² S. Uemoto,² T. Kaido.²
¹Department of Surgery, Mansoura University, Mansoura, Dakahliya, Egypt; ²Division of Hepato-Biliary-Pancreatic and Transplant Surgery Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Background/purpose: The effects of body composition disturbances on liver transplantation outcomes have recently been in focus. However, the effects of obesity, as well as sarcopenic…
2016 American Transplant Congress
Fatigue, Pain, and Other Physical Symptoms of Living Liver Donors.
Z. Butt,¹ A. DiMartini,² Q. Liu,³ M. Simpson,⁴ A. Smith,^3,5 J. Zee,³ B. Gillespie,⁵ S. Holtzman,⁶ D. Ladner,¹ K. Olthoff,⁷ R. Fisher,⁸ S. Hafliger,⁹ C. Freise,¹⁰ M. Mandell,¹¹ M. Dew.²
¹Northwestern U, Chicago; ²U of Pittsburgh, Pittsburgh; ³Arbor Research Collaborative for Health, Ann Arbor; ⁴Lahey, Burlington; ⁵U of Michigan, Ann Arbor; ⁶U of Toronto, Toronto, Canada; ⁷U of Pennslyvania, Philadelphia; ⁸Virginia Commonwealth U, Richmond; ⁹Columbia U, New York; ¹⁰U of California at San Francisco, San Francisco; ¹¹U of Colorado, Denver.
Background: Post-operative pain and fatigue can be significant for some living liver donors (LLD). A better appreciation of these outcomes may inform pre-donation education and…
2016 American Transplant Congress
Long Term Outcome of Kidney Transplant Recipients Treated with Everolimus: Final 5-Years Results from the Certic Observational Study.
L. Furian,¹ L. Di Maria,² G. Cappelli,³ M. Carmellini,⁴ G. Spagnoletti,⁵ G. Piredda,⁶ P. Todeschini,⁷ S. Chiaramonte,⁸ G. Tisone.⁹
¹AOU di Padova, Padova, Italy; ²AOU Careggi, Firenze, Italy; ³AOUP di Modena, Modena, Italy; ⁴AOU Senese, Siena, Italy; ⁵PU A.Gemelli, Roma, Italy; ⁶AO G.Brotzu, Cagliari, Italy; ⁷AOP S.Orsola-Malpighi, Bologna, Italy; ⁸PO S.Bortolo, Vicenza, Italy; ⁹Fondazione PU Tor Vergata, Roma, Italy.
Everolimus is associated with long-term benefits, such as preserving renal function and reducing the incidence of infections, malignancies and major cardiovascular events (MACE). The Certic…
2016 American Transplant Congress
Long-Term Deterioration of Graft Function (DeKAF) Study: Histologic Interpretation of Cross-sectional vs Prospective Cohorts.
A. Matas,¹ A. Fieberg,¹ L. Hunsicker,² J. Grande,³ For the DeKAF Group.
¹U of MN, Mpls, MN; ²U IA, Iowa City, IA; ³Mayo, Rochester, MN.
The major aim of the DeKAF study was to define previously unidentified phenotypes resulting in late graft dysfunction and loss (GL). Two cohorts were developed,…
2016 American Transplant Congress
Complex Constellation of HLA Antibodies Contributes to Decreasing Trend of Transplant Rate in Candidates with 100% CPRA.
R. Rajalingam, D. Hyon Gae, D. Kopchaliiska, O. Buenaventura, K. Cunniffe, G. Da Gente, J. Roberts.
Immunogenetics and Transplantation Laboratory; Department of Surgery, University of California-San Francisco, San Francisco, CA.
The key component of new KAS is offering an increased priority for sensitized candidates. While transplants (tx) have increased six-fold for recipients with a CPRA…
2016 American Transplant Congress
A Selective Biomarker in Blood Cells Identifies IFTA After Kidney Transplantation.
M. Matz,¹ C. Lorkowski,¹ K. Wu,³ H.-H. Neumayer,¹ M.-F. Mashreghi,² K. Budde.¹
¹Nephrology, University Charité, Berlin, Germany; ²German Rheumatism Research Center (DRFZ), Berlin, Germany; ³Pathology, University Medicine Charité, Berlin, Germany.
Cellular and antibody-mediated rejection processes and also interstitial fibrosis/tubular atrophy (IFTA) lead to allograft dysfunction and loss. The search for accurate and specific diagnostic tools…
2016 American Transplant Congress
CD45RO+/CD62L- Effector Memory T Cells Mediate Depletion Resistant Allograft Rejection in Intestinal Transplant Recipients.
C. Cosentino, J. Kaiser, A. Shukla, C. Desai, R. Girlanda, J. Hawksworth, C. Matsumoto, M. Zasloff, T. Fishbein, A. Kroemer.
MedStar Georgetown Transplant Institute, Washington DC.
A. A high risk of acute cellular rejection (ACR) is one of the key factors limiting intestinal transplantation (ITx). An extremely poor prognosis is related…
2016 American Transplant Congress
Exosome-Like Vesicles Released in Association with Tissue Injury Trigger Anti-LG3 Production.
M. Dieudé,^1,2,3 J. Turgeon,^1,3 B. Yang,^1,2,3 L. Pomerleau,^1,3 K. Hamelin,^1,3 S. Lan,^1,2,3 S. Qi,^1,3 D. Gingras,^1,3 W. Dhari,¹ A. Rivard,¹ M.-J. Hébert.^1,2,3
¹Research Centre, Centre hospitalier de l'Université de Montréal, Montréal, Canada; ²Université de Montréal, Montréal, Canada; ³Canadian National Transplantation Research Program, Edmonton, Canada.
Pre-transplant levels of autoantibodies to perlecan/LG3 predict poor allograft outcomes in renal transplant patients. We showed previously thatapoptotic exosome-like vesicles (ApoExo) enhance anti-LG3 production and…
2016 American Transplant Congress
Aryl Hydrocarbon Receptor Expression Increases in Skin Graft-infiltrating Th1 and Treg Cells.
J. Fechner, W. Julliard, L. Owens, J. Mezrich.
Surgery, University of Wisconsin, Madison, WI.
Hypothesis: The expression of the aryl hydrocarbon receptor (AHR), a transcription factor activated by a variety of exogenous and endogenous ligands including the typtophan-metabolite kynuenine,…
2016 American Transplant Congress
Long-Term Islet Xenograft Survival Requires Effective Control of Early Xenogeneic IL-17 Response and Late Xenogeneic IFN-γ Response.
H. Kang,¹ S. Wang,² X. Zhang,³ A. Singh,⁵ L. Zhang,¹ W. Suarez-Pinzon,⁵ S. Miller,⁴ B. Hering,⁵ X. Luo.^1,3,4
¹Medicine, Northwestern University, Chicago, IL; ²Surgery, Tianjin Union Medical Center, Tianjin, China; ³Comprehensive Transplant Center, Northwestern University, Chicago, IL; ⁴Microbiology and Immunology, Northwestern University, Chicago, IL; ⁵Schulze Diabetes Institute, University of Minnesota, Minneapolis, MN.
Introduction: Tolerance induction for xenogeneic islet transplant remains a challenge. We have previously shown that peri-transplant infusion of donor cells treated with 1-ethyl-3-(3'-dimethylaminopropyl)-carbodiimide (ECDI) is…