Am J Transplant, Volume 16, Suppl 3 Archives - Page 62 of 180 - ATC Abstracts

2016 American Transplant Congress
Targeting IFN-g-Expressing TIM-4⁺B Effector (Beff) Cells as a Novel Strategy to Prevent Allograft Rejection.
Q. Ding,¹ K. Mohib,¹ S. Xiao,² V. Kuchroo,² D. Rothstein.¹
¹University of Pittsburgh, Pittsburgh; ²Harvard Medical School, Boston.
B cell depletion can augment or inhibit auto- and allo- immune responses in humans and mice without altering Ig levels. This is likely due to…
2016 American Transplant Congress
Mechanistic Insights into How Targeting of HDAC10 Promotes Foxp3+ Treg Cell Suppressive Activity, Gene Expression and Metabolism, and Enhances Allograft Survival.
S. Dahiya,¹ L. Wang,¹ U. Beier,^1,2 A. Angelin,¹ R. Han,¹ D. Wallace,^1,2 W. Hancock.^1,2
¹Children's Hospital of Philadelphia, Philadelphia; ²University of Pennsylvania, Philadelphia.
Foxp3+ T-regulatory (Treg) cells are key regulators of immune responses that can result in unwarranted inflammation and promote allograft rejection. From a theoretical perspective, targeting…
2016 American Transplant Congress
Characteristics and Outcomes of Vancomycin Resistant Enterococcus Bacteremia After Liver Transplant.
R. Odrobina,¹ C. Kovacs,¹ R. Butler,² C. Koval.¹
¹Department of Infectious Diseases, Cleveland Clinic, Cleveland, OH; ²Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH.
Vancomycin Resistant Enterococcus (VRE) infection is reported in 5-20% of liver transplant (LT) recipients and is associated with decreased survival. Published data includes infections of…
2016 American Transplant Congress
Biliary Epithelial Damage, Regenerative Capacity and Local Immune Response After Cold Storage of DBD Livers Determine Biliary Complications After Liver Transplantation.
S. Brunner, H. Junger, H. Schlitt, S. Fichtner-Feigl.
Department of Surgery, University Medical Center Regensburg, Regensburg, Germany.
Background: The aim of this study was to examine the development and molecular mechanisms of bile duct (BD) damage between organ retrieval and transplantation and…
2016 American Transplant Congress
Effect of mTOR Inhibitors on the Risk of Cancer Development After Kidney Transplantation in Chinese Population.
C.-C. Kao,¹ J.-S. Liu,² M.-H. Lin,² F.-C. Chang,¹ Y.-C. Lin,¹ H.-H. Chen,¹ T.-W. Chen,¹ C.-C. Hsu,² M.-S. Wu.¹
¹Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan; ²Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
Introduction The mTOR inhibitor is an immunosuppressive drug used in kidney transplantation. Whether the mTOR inhibitors is associated with reduced risk of cancer development in…
2016 American Transplant Congress
Everolimus (EVR) versus Mycophenolate Sodium (MPS) for Recipients of Kidney Transplants from Expanded Criteria Donors (ECD) Receiving Anti-Thymocyte Globulin (r-ATG) and Tacrolimus (TAC).
H. Tedesco-Silva,¹ C. Felipe,¹ A. Brigido,¹ A. Bessa,¹ M. Paula,¹ P. Ruppel,¹ M. Cristelli,¹ L. Viana,¹ G. Basso,¹ M. Franco,² W. Aguiar,¹ J. Medina-Pestana.¹
¹Nephrology Division, Hospital do Rim - UNIFESP, Sao Paulo, Brazil; ²Pathology Division, UNIFESP, Sao Paulo, Brazil.
Introduction: There is no standard of care immunosuppressive regimen for recipients of kidneys recovered from expanded criteria donors. Several centers use r-ATG induction due to…
2016 American Transplant Congress
Crisis on the Waiting List for Children Listed in Low Volume Solid Organ Transplant Centers.
A. Rana, E. Brewer, W. Winkelmayer, C. O'mahony, J. Goss.
Department of Abdominal Transplantation, Baylor College of Medicine, Houston, TX.
Purpose: In a recent analysis, we demonstrated that children listed in low volume liver transplant centers had poor waitlist survival and a depressed transplant rate…
2016 American Transplant Congress
Utilization of HCV-Positive Donors' Kidneys: Potential Benefits in the Era of Direct Acting Antiviral (DAA) Therapy.
B. Amundsen,¹ M. Sise,² M. Lin,³ H. Deirawan,¹ E. Heher,² B. Kimball,¹ J. Markmann,¹ N. Elias.¹
¹Massachusetts General Hospital, Boston, MA; ²Massachusetts General Hospital, Boston, MA; ³Brigham and Women's Hospital, Boston, MA.
Organ shortage and expanding kidney waiting list fostered utilization of HCV positive donors' organs (HCVD+). HCVD+ kidneys have slightly worse long term outcomes compared with…
2016 American Transplant Congress
HO-1/SIRT1/p53 Axis Regulates Macrophage Activation and Attenuates Liver Ischemia-Reperfusion Injury in Mice.
K. Nakamura,¹ M. Zhang,² B. Ke,¹ S. Kageyama,¹ R. Busuttil,¹ J. Araujo,² J. Kupiec-Weglinski.¹
¹Surgery, Liver Transplant, University of California-Los Angeles, Los Angeles, CA; ²Medicine, Division of Cardiology, University of California-Los Angeles, Los Angeles, CA.
Background/Aim: The mechanism by which macrophage heme oxygenase-1 (HO-1)-Sirtuin1 (SIRT1) signaling promotes resistance against inflammation response in liver ischemia-reperfusion injury (IRI) remains elusive. As tumor…
2016 American Transplant Congress
Thoracic Simulation Allocation Modeling (TSAM) of a 6-Tier Allocation Strategy.
M. Colvin,¹ M. Skeans,¹ L. Robbins Callahan,² L. Edwards,² J. Zeglin,¹ S. Silvestry,³ R. Davies,⁴ M. Farr,⁵ A. Israni,¹ J. Rogers.⁶
¹SRTR, Minneapolis; ²UNOS, Richmond; ³Florida Hospital Transplant Inst, Orlando; ⁴Nemours/AI duPont Hosp for Children, Wilmington; ⁵Columbia Univ Medical Center, New York; ⁶Duke Univ, Durham.
Heart allocation policy (OPTN policy 6) is in development. To stratify medical urgency, the Heart Subcommittee of the OPTN Thoracic Committee developed a 6-tier algorithm…