Am J Transplant, Volume 16, Suppl 3 Archives - Page 6 of 180 - ATC Abstracts

2016 American Transplant Congress
Angiotensin II Type 1 Receptor Antibodies Are Associated with Allograft Loss in Pediatric Renal Transplantation.
M. Pearl,¹ Q. Zhang,² M. Palma Diaz,³ J. Grotts,⁴ J. Brook,⁴ D. Gjertson,² P. Weng,¹ E. Reed,² E. Tsai.¹
¹Pediatrics, University of California-Los Angeles, Los Angeles, CA; ²Pathology and Laboratory Medicine, University of California-Los Angeles, Los Angeles, CA; ³Anatomic & Clinical Pathology, University of California-Los Angeles, Los Angeles, CA; ⁴Biostatistics, University of California-Los Angeles, Los Angeles, CA.
Background: Angiotensin II type 1 receptor antibody (AT1R-Ab) is associated with vascular injury and allograft failure in adult kidney transplantation. Its role in pediatric transplantation…
2016 American Transplant Congress
Functional Status and Comorbidity Are Associated with High Costs After Liver Transplantation.
M. Serper, M. Rossi, T. Bitterman, A. Shaked, K. Olthoff.
University of Pennsylvania, Philadelphia.
Purpose: The purpose of this study was to identify the clinical characteristics associated with high costs of liver transplantation (LT) at a large transplant center…
2016 American Transplant Congress
Mothers Are Often Sensitized and Sensitive: Antibody Mediated Rejection in Child to Mother Living Donor Liver Transplantation.
B. Movahedi,¹ N. Yu,² P. Martins,¹ A. Ahearn,¹ J. Stoff,¹ A. Bozorgzadeh.¹
¹Division of Organ Transplantation, UMass Memorial Medical Center, Worcester, MA; ²Clinical Pathology, Histocompatibility Laboratory, UMass Memorial Medical Center, Worcester, MA.
Background: Partial graft is especially more vulnerable to deleterious effects of donor specific HLA antibodies (DSA). Living liver donors and recipients are often family members.…
2016 American Transplant Congress
Effect of Angiotensin Converting Enzyme Inhibitor (ACEI) or Angiotensin Receptor Blockade (ARB) Exposure on Intragraft Gene Expression of Kidney Transplant Patients.
C. Suarez-Fuentes,^1,2,4 P. O Broin,³ Y. Bao,¹ E. Akalin.^1,2
¹Kidney Transplant, Montefiore Medical Center, Bronx, NY; ²Albert Einstein College of Medicine, Bronx, NY; ³National University of Ireland Galway University, Galway, Ireland; ⁴Funded by NIH T-32 DK007110, National Institute of Health, Bethesda, MD.
Objective: Treatment with ACEI or ARB has been shown to have anti-inflammatory effects in animal models but this effect has not been investigated in kidney…
2016 American Transplant Congress
Induction Immunosuppression and Post-Transplant Outcomes in Kidney Recipients with Hepatitis C Virus.
S. Bae, C. Durand, L. Kucirka, A. Massie, D. Segev.
Johns Hopkins, Baltimore, MD.
Kidney transplantation is a well-established treatment option for ESRD patients with Hepatitis C virus (HCV). However, the optimal induction regimen for this population is uncertain,…
2016 American Transplant Congress
Successful Maintenance Belatacept-Based Immunosuppression in Lung Transplantation Recipients Who Failed Calcineurin Inhibitors.
C. Ensor, R. Winstead, B. Johnson, M. Morrell, S. Kilaru, C. Moore, J. Hayanga, A. Zeevi, E. Lendermon, J. McDyer.
University of Pittsburgh, Pittsburgh, PA.
Purpose: Describe response of belatacept (BELA) immunosuppression regimen (ISR) conversion in lung transplantation recipients (LTRs) after calcineurin inhibitor (CNI) failure on incidence of cellular rejection…
2016 American Transplant Congress
Post Transplantation High-Dose Cyclophosphamide Treatment Promotes Immune Tolerance After Skin, Solid Organ, and Vascularized Composite Allotransplantation.
G. Furtmüller,¹ B. Oh,¹ M. Fryer,^1,4 P. Akre,¹ S. Ganguly,² J. Dodd-o,³ D. Cooney,¹ G. Raimondi,¹ W. Lee,¹ L. Luznik,² G. Brandacher.¹
¹Department of Plastic and Reconstructive Surgery, Johns Hopkins Medicine, Baltimore, MD; ²Immunology - Sydney Kimmel Cancer Center, Johns Hopkins Medicine, Baltimore, MD; ³Department of Anesthesiology, Johns Hopkins Medicine, Baltimore, MD; ⁴Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA.
Background: Developing novel approaches to minimize/avoid immunosuppression by induction of immune tolerance represents the prime task in the field of transplantation. Methods: Murine skin, heart,…
2016 American Transplant Congress
A Single Histone/protein Acetyltransferase, Tip60, Is Absolutely Essential for Treg Survival and Function, and Its Inhibition Abrogates Induction of Treg-Dependent Allograft Tolerance.
L. Wang,¹ A. Beeler,² S. Dahiya,¹ R. Han,¹ W. Hancock.¹
¹CHOP & UPenn, Philadelphia, PA; ²Boston University, Boston, MA.
Based on in vitro studies and limited in vivo data from patients with mutations in FOXP3 or animals with depletion of circulating Tregs, Tregs are…
2016 American Transplant Congress
Comparison of C4d Deposition in Renal Biopsies with Luminex-Based C3d Single Antigen Bead (SAB) Detection.
R. Pelletier,¹ I. Balazs,² P. Adams,³ P. Steller,³ N. DiPaola,⁴ L. Rankin,³ A. Diez,⁵ M. Henry.¹
¹Surgery/Transplant, The Ohio State University Wexner Medical Center, Columbus, OH; ²Discovery Research, Immucor, Inc, Stamford, CT; ³Tissue Typing, The Ohio State University Wexner Medical Center, Columbus, OH; ⁴Methodist Hospital, Houston, TX; ⁵Nephrology, The Ohio State University Wexner Medical Center, Columbus, OH.
Recent interest in characterizing the complement-fixing ability of post-transplant donor specific alloantibodies (DSA) resulted in the enhancement of luminex solid phase alloantibody assays to determine…
2016 American Transplant Congress
Polyclonal Treg Adoptive Therapy for Control of Subclinical Kidney Transplant Inflammation (TASK Pilot Trial).
S. Chandran, Q. Tang, M. Sarwal, Z. Laszik, A. Putnam, T. Sigdel, E. Tavares, J. Bluestone, F. Vincenti.
UCSF, San Francisco, CA.
Purpose: Early renal graft inflammation is associated with progressive fibrosis & late dysfunction. Treg therapy can reverse established inflammation in animal models. We conducted a…

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