Am J Transplant, Volume 16, Suppl 3 Archives - Page 57 of 180 - ATC Abstracts

2016 American Transplant Congress
Novel Function of CD4⁺ T Cell DEPTOR in Treg Homeostasis and Alloimmunity.
J. Wedel,^1,2 S. Bruneau,^1,2 K. Liu,^1,2 N. Kochupurakkal,^1,2 M. Laplante,³ D. Briscoe.^1,2
¹Division of Nephrology, Boston Children's Hospital, Boston, MA; ²Transplant Research Program, Harvard Medical School, Boston, MA; ³CRIUCPQ, Université Laval, Quebec, Canada.
DEPTOR, a recently described modulator of PI-3K/mTOR signaling, is expressed by CD4+ T cells, and functions to modulate CD4+ Teff cell differentiation. Upon CD4+ T…
2016 American Transplant Congress
Impact of Donor-Recipient Relationship on Development of CKD.
A. Matas, D. Vock, H. Ibrahim.
UMN, Mpls, MN.
Two studies have reported a small increase of ESRD in LDs compared to healthy matched controls. However, the majority of ESRD has been in relatives…
2016 American Transplant Congress
Use of Small (<10kg) Kidney Donors in the US.
J. Smith,^1,2 J. Snyder,¹ A. Israni,¹ B. Kasiske,¹ R. Perez.³
¹Scientific Registry of Transplant Recipients, Minneapolis; ²Seattle Children's Hospital, Seattle; ³UC Davis Medical Center, Sacremento.
The supply of kidneys for transplant continues to exceed the demand. Efforts to expand the donor pool have led to interest in small pediatric kidney…
2016 American Transplant Congress
Establishing the Relationship Between Receptor Occupancy, Serum Exposure and Pathway Inhibition by the Blocking, Non-Depleting Anti-CD40 Antibody CFZ533 to Inform Dose Selection in Clinical Transplantation.
P. Espie, J. Munz, T. Flandre, B. Haraldsson, P. Ulrich, J. Rush.
Novartis Institutes for Biomedical Research, Basel, Switzerland.
Background. CD40-CD154 pathway blockade significantly prolongs renal allograft survival in non-human primates (NHPs), and trials of the novel blocking, non-depleting anti-CD40 monoclonal antibody (mAb) CFZ533…
2016 American Transplant Congress
Frailty in KT Recipients of All Ages.
M. McAdams-DeMarco, H. Ying, I. Olorundare, E. King, D. Segev.
Johns Hopkins, Baltimore.
Background: Among KT recipients, frailty increases the risk of DGF, early hospital readmission and mortality. While it is clear that frail KT recipients represent a…
2016 American Transplant Congress
Graft Survival of Steroid-Avoidance Protocols in Pediatric Kidney Transplantation[mdash]A Propensity Score Analysis.
E. Nehus,¹ Y. Wang,² B. Lu,³ C. Liu,² M. Macaluso,² M.-O. Kim.²
¹Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; ²Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; ³Division of Biostatistics, The Ohio State University, Columbus, OH.
Purpose: This study investigated whether steroid avoidance-protocols adversely influence allograft survival among pediatric kidney transplant recipients at high levels of immunologic risk.Methods: A retrospective cohort…
2016 American Transplant Congress
Lower Renal Graft Function and Accelerated Fibrosis in HIV-Infected Transplant Recipients with Previous HIVAN Compared to Non HIVAN HIV-Positive Transplant Recipients.
M.-N. Peraldi,¹ H. Ayari,¹ M. Burbach,¹ C. Randoux,² E. Pillebout,¹ N. De Castro,³ J.-M. Molina,³ D. Glotz.¹
¹Nephrologie et Transplantation, Hôpital Saint-Louis et Université Paris-Diderot, Paris, France; ²Néphrologie, Hôpital Bichat et Université Paris-Diderot, Paris, France; ³Service de Maladies Infectieuses, Hôpital Saint-Louis et Université Paris-Diderot, Paris, France.
Several studies reported reduced renal allograft survival rates among HIV-infected transplant recipients. Few data focus on histological lesions and their progression in renal grafts from…
2016 American Transplant Congress
Survival Advantage with Older Live Donor Compared to Standard Criteria Deceased Donor Kidney Transplantation in Older Recipients.
P. Abrams, M. Cooper, J. Verbesey, R. Ghasemian, M. Grafals, A. Gilbert, J. Moore, J. Fenton, C. Cannon, J. Rapisurra, B. Javaid.
MedStar Georgetown Transplant Institute, Georgetown University School of Medicine, Washington, DC.
Objective: Analyze post-transplant outcomes in older recipients of kidney transplants from older live donors compared to older recipients of standard criteria deceased donor kidney transplants.Methods:…
2016 American Transplant Congress
HLA Antibody in Transplant Recipients During Transition from Paediatrics.
S. Kaki,¹ A. Lunn,² J. Goodwin,³ T. Key,³ W. McKane.¹
¹Renal, Sheffield Kidney Institute, Sheffield, United Kingdom; ²Renal, Queens Medical Centre, Sheffield, United Kingdom; ³Histocompatibility and Immunogenetics, National Health Service blood and transplantation, Sheffield, United Kingdom.
Objective:Adolescent transplant recipients in transition from paediatric to adult units are known to be at high risk of graft failure. Detection of HLA antibody is…
2016 American Transplant Congress
Post-Transplant T-Cell Alloreactive Perturbation Precedes the Advent of Humoral Immunity in Kidney Transplant Patients.
E. Crespo,¹ S. Luque,¹ J. Cruzado,² E. Melilli,² J. Grinyo,² M. Lucia,¹ O. Bestard.²
¹Experimental Nephrology Laboratory, IDIBELL, Barcelona, Spain; ²Kidney Transplant Unit, Bellvitge University Hospital, Barcelona, Spain.
Subclinical inflammation in kidney allografts is associated with worse outcome and the activation of humoral alloimmunity. Surveillance allograft biopsies are an accurate tool to diagnose…