Am J Transplant, Volume 16, Suppl 3 Archives - Page 48 of 180 - ATC Abstracts

2016 American Transplant Congress
The Impact of Ritonavir-Boosted Protease Inhibitors and Non-Depleting Antibody Induction on Outcomes in HIV-Infected Kidney Transplant Recipients.
B. Rollins, S. Lerner, M. Rana, S. Huprikar, L. Miko, V. Nair, S. Florman, R. Shapiro.
Mount Sinai Hospital, New York.
Background: One-year rejection rates in HIV-infected kidney transplant recipients range from 15-40%, compared to overall rejection rates of 10% in HIV-negative patients. Protocols for immunosuppression…
2016 American Transplant Congress
High-Risk Age Window for Graft Loss in Pediatric Lung and Heart Transplant Recipients.
B. Orandi, X. Luo, K. Van Arendonk, R. Higgins, D. Segev.
Johns Hopkins University, Baltimore.
Late adolescence and early adulthood is a high-risk age window for pediatric kidney graft loss, though not for pediatric liver graft loss. It is unknown…
2016 American Transplant Congress
Cold Storage Stabilization of Gap Junctions Reduces Post Transplant Ischemia Reperfusion Injury.
R. Finnegan,¹ P. Zhu,¹ S. Stephenson,¹ K. Patel,² S. Nadig,^1,2,3 C. Atkinson.^1,2,3
¹Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC; ²Department of Surgery, Medical University of South Carolina, Charleston, SC; ³South Carolina Investigators in Transplantation, Medical University of South Carolina, Charleston, SC.
Purpose: Organ procurement, cold storage and ischemia reperfusion injury (IRI) promote inflammation, which induces endothelial cell (EC) activation and dysfunction post transplantation. EC gap junctions…
2016 American Transplant Congress
Regulatory T Cell Infusion Can Enhance Memory T Cell and Alloantibody Responses in Lymphodepleted Nonhuman Primate Heart Allograft Recipients.
M. Ezzelarab,¹ H. Zhang,¹ L. Lu,¹ H. Guo,¹ A. Zahorchak,¹ R. Wiseman,² M. Nalesnik,³ J. Bhama,¹ D. Cooper,¹ A. Thomson.^1,4
¹Surgery, University of Pittsburgh, Starzl Institute, Pittsburgh, PA; ²Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI; ³Pathology, University of Pittsburgh, Pittsburgh, PA; ⁴Immunology, University of Pittsburgh, Pittsburgh, PA.
Background:The ability of regulatory T cells (Treg) to prolong allograft survival and promote transplant tolerance in lymphodepleted rodents is well-established. Few studies have addressed the…
2016 American Transplant Congress
Mapping Heterogeneity in Antibody-Mediated Rejection Using Molecular Phenotypes and Archetype Analysis.
J. Reeve,¹ P. Halloran.^1,2
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada; ²Medicine, University of Alberta, Edmonton, AB, Canada.
Archetype analysis is a method for identifying new relationships among samples without subdividing them into classes, finding a limited number of archetypical cases and calculating…
2016 American Transplant Congress
Predictors of eGFR Slope at One Year in Kidney Transplants – A Big Data Approach.
J. Zhang, Z. Su, D. Taber, J. Marsden, W. Moran, P. Mauldin, T. Srinivas.
MUSC, Charleston.
Background: Estimated glomerular filtration rate (eGFR), a predictor of graft loss (GL) in kidney transplantation could inform intervention. National data yield eGFRs at fixed time…
2016 American Transplant Congress
Wait List Removals and Transplant Rates Are Significantly Associated with Transplant Center Performance Oversight.
J. Schold, L. Buccini, E. Poggio, S. Flechner, D. Goldfarb.
Cleveland Clinic, Cleveland, OH.
Prior studies indicate that low performance(LP) center evaluations by the SRTR are associated with reductions in transplant volume. There is limited information to determine whether…
2016 American Transplant Congress
Utilization and Discard of HCV+ Donor Livers in the Advent of Direct-Acting Antiviral Therapy.
M. Bowring, L. Kucirka, A. Massie, X. Luo, M. Sulkowski, D. Segev, C. Durand.
JHU, Baltimore.
While 45% of liver candidates are hepatitis C (HCV)-antibody positive (+) and might benefit from a HCV+ donor liver, only a small proportion receive one.…
2016 American Transplant Congress
Insights into the Treatment of Post-Transplant Focal Glomerulosclerosis: Experience Gained from a Concise Diagnostic and Management Protocol.
K. Koutroutsos,¹ R. Charif,¹ L. Moran,² J. Moss,² T. Cook,² C. Roufosse,² D. Taube,¹ M. Loucaidou.¹
¹Kidney and Transplant Centre, Imperial Healthcare NHS Trust, London, United Kingdom; ²Department of Histopathology, Imperial Healthcare NHS Trust, London, United Kingdom.
Background: Recurrence of Focal Glomerulosclerosis (FSGS) after kidney transplantation is associated with poor graft survival. We present results from a concise diagnostic and management protocol…
2016 American Transplant Congress
Donor-Recipient Absolute Weight Mismatch and the Risk of Graft Loss in Renal Transplantation.
A. Miller,¹ B. Kiberd,¹ I. Alwayn,² K. Tennankore.¹
¹Medicine, Division of Nephrology, Dalhousie University, Halifax, NS, Canada; ²Surgery, Multi Organ Transplant Program, Dalhousie University, Halifax, NS, Canada.
Background: Relatively smaller kidney donor to recipient size is proposed to result in increased graft loss due to nephron underdosing and hyperfiltration injury but few…