ATC Abstracts

American Transplant Congress abstracts

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  • 2016 American Transplant Congress

    Factors Predicting Tacrolimus Trough Variability After Lung Transplantation.

    K. Boyle, M. Moranville, P. Shah.

    The Johns Hopkins Hospital, Baltimore, MD.

    Background: Recent data suggests that variability in tacrolimus trough concentrations is associated with acute and chronic rejection. The purpose of this study was to identify…
  • 2016 American Transplant Congress

    An Epidemiological Update of Non-Melanoma Skin Cancer in Immunosuppressed Organ Transplant Recipients with Skin of Color.

    C. Shaver, C. Cusack, C. Chung.

    Dermatology, Drexel University College of Medicine, Philadelphia, PA.

    Introduction:It is predicted by the US census that by year 2050, minorities will become the majority US population. We know skin cancer in patients with…
  • 2016 American Transplant Congress

    Risk of Acute Rejection Among ABO Incompatible Living Donor Kidney Recipients.

    P. MacLennan, V. Kumar, R. Reed, D. Mompoint-Williams, K. Stegner, J. Locke.

    School of Medicine, University of Alabama at Birmingham, Birmingham, AL.

    Background: ABO incompatible (ABOi) live donor kidney transplantation (LDKT) holds the potential for increased access to transplantation for ESRD patients. Concerns remain related to the…
  • 2016 American Transplant Congress

    Early Onset Acute Antibody Mediated Rejection (ABMR) Is More Common in Female Than in Male Recipients of a Living Unrelated Donor (LURD) Renal Transplant and Is Associated with the Presence of Preformed Donor Specific Antibodies (DSA).

    D. Soonawala,1 K. Groeneweg,1 F. van der Toorn,1 S. Heidt,2 D. Roelen,2 F. Claas,2 J. de Fijter.1

    1Nephrology, LUMC, Leiden, Netherlands; 2IHB, LUMC, Leiden, Netherlands.

    Introduction: Women who receive a renal graft from their male spouse have a higher risk of early onset acute ABMR. The aim of this study…
  • 2016 American Transplant Congress

    Comparison of De Novo Donor Specific Antibody Formation for Kidney Transplant Recipients Induced with Thymoglobulin or Basiliximab.

    A. Gong, K. Lee, S. Patel, M. Brande, R. Dhawan, C. Parke, M. Smogorzewski, L. Aguirre, B. Duong, S. Alexopolus, Y. Qazi.

    Division of Transplantation, University of Southern California, Los Angeles, CA.

    Background: Thymoglobulin (ATG) and basiliximab (Bas) induction are commonly used therapies to prevent allograft rejection in kidney transplant recipients (KTx). Formation of donor specific antibodies…
  • 2016 American Transplant Congress

    National Trends in Liver Discards: The Weekend Effect.

    D. Carpenter,1 S. Mohan,2 K. Halazun,3 E. Verna,5 M. Chiles,2 G. Charak,1 L. Ratner.4

    1Surgery, Columbia University Medical Center, New York City, NY; 2Medicine, Division of Nephrology, Columbia University Medical Center, New York City, NY; 3Department of Surgery, Division of Transplantation, Weill Cornell Medical Center, New York City, NY; 4Department of Surgery, Division of Transplantation, Columbia University Medical Center, New York City, NY; 5Department of Medicine, Center for Liver Disease and Transplantation, Division of Digestive and Liver Diseases, Columbia University Medical Center, New York City, NY.

    Overall organ discard rates have increased over the last decade. Given the current organ shortage, understanding factors that contribute to the discard of livers is…
  • 2016 American Transplant Congress

    Reduced Incidence of Cytomegalovirus Infection in Kidney Transplant Recipients Receiving Everolimus: A Cost-Effectiveness Analyses.

    H. Tedesco-Silva, C. Felipe, A. Brigido, M. Cristelli, M. Paula, A. Bessa, P. Ruppel, J. Medina-Pestana.

    Nephrology Division, Hospital do Rim - UNIFESP, Sao Paulo, Brazil.

    A cost-effectiveness analysis was performed using data from a prospective single center trial where de novo kidney transplant recipients received a single 3 mg/kg dose…
  • 2016 American Transplant Congress

    Recombinant TSGL-Ig Protects Liver Endothelial Cells Against Prolonged Cold Preservation Injury in Mouse Liver Transplantation.

    C. Zhang,1,2 H. Ji,1 Y. Liu,1,2 Y. Zhang,1,2 X.-D. Shen,1 F. Gao,1 R. Busuttil, G. Shaw, J. Kupiec-Weglinski.

    1Dumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at University of California-Los Angeles, Los Angeles, CA; 2Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

    Background: Liver endothelial cells (LEC) suffer from ROS-mediated stress in the pathogenesis of liver ischemia-reperfusion injury (IRI). We used a novel recombinant form of soluble…
  • 2016 American Transplant Congress

    Distinctive Roles of Gsk3 Inhibitory Phosphorylation in Liver Inflammatory Immune Response and Hepatocellular Injury Against Ischemia Reperfusion.

    H. Zhou,1,2 J. Zhu,1 S. Yue,1 R. Busuttil,1 J. Kupiec-weglinski,1 L. Lu,2 Y. Zhai.1

    1Surgery, David Geffen School of Medicine-UCLA, Los Angeles, CA; 2Liver Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.

    Background & AimsGlycogen synthase kinase 3 (Gsk3) a and b are ubiquitously expressed, constitutively active serine/threonine kinases, which play complex roles in cell activation, proliferation…
  • 2016 American Transplant Congress

    Attenuation of Warm Hepatic Ischemia-Reperfusion Injury by Bruton's Tyrosine Kinase Inhibition.

    A. Zarrinpar,1 T. Palumbo,1 K. Nakamura,1 C. Lassman,2 R. Busuttil,1 J. Kupiec-Weglinski.1

    1Surgery, Dumont-UCLA Translant Center, Los Angeles, CA; 2Pathology, UCLA, Los Angeles, CA.

    Bruton's tyrosine kinase (Btk) is a central player in multiple signaling pathways in lymphoid and myeloid cells, including neutrophils. Neutrophils are crucial effectors in the…
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