ATC Abstracts

American Transplant Congress abstracts

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  • 2016 American Transplant Congress

    The Surgical Preconditioning in Patients with Ultra-Short Gut Using a Native Colonic Conduit for Anticipated Visceral Transplantation.

    M. Fujiki, K. Hashimoto, A. Khanna, K. Abu-Elmagd.

    Center of Gut Rehabilitation and Transplant, Cleveland Clinic, Cleveland, OH.

    Objective: The last decade witnessed the significant improvement in the morbidity and mortality of short gut syndrome (SGS) patients. However, still a challenge is the…
  • 2016 American Transplant Congress

    Direct Alloimmunity Is Driven by Recipient APCs Displaying Donor MHC Molecules.

    J. Marino,1 J. Paster,1 P. Crosby,1 M. Uehara,2 S. Mordecai,1 R. Abdi,2 G. Tocco,1 G. Benichou.1

    1Surgery Department, Center for Transplantation Sciences, Massachusetts General Hospital/Harvard Medical School, Boston, MA; 2Department of Medicine, Renal Division, Brigham and Women's Hospital, Boston, MA.

    We have studied the trafficking of donor passenger leukocytes and donor MHC presentation in the lymphoid organs of mice having received an MHC-mismatched skin or…
  • 2016 American Transplant Congress

    The Impact of a Novel Dual Adenosine Triphosphate-Competitive mTOR Inhibitor (TORKinib) on Alloimmunity and Transplant Survival.

    D. Fantus,1 Y. Ono,1 S. Yokota,1 C. Komatsu,1 H. Turnquist,1,2 A. Thomson.1,2

    1Surgery, Thomas E Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA; 2Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA.

    Background: Rapamycin (RAPA), an immunosuppressive agent, inhibits the mechanistic target of Rapamycin (mTOR), the kinase subunit of two mTOR- containing complexes (mTORC1 and mTORC2). While…
  • 2016 American Transplant Congress

    Function of Sertoli Cells in Regulating Allogeneic T Cell Differentiation into Treg and Th17 In Vitro.

    L. Xie,1 W. Jiang.2

    1Institute of Organ Transplantation, Tongji Hospital, HUST, Wuhan, China; 2Department of Rheumatology, China-Japan Friendship Hospital, Beijing, China.

    The testis as an immune-privileged site allows long-term survival of allogeneic and xenogeneic transplants. Testicular Sertoli cells (SCs) can confer local immunoprotection for cotransplanted cells…
  • 2016 American Transplant Congress

    Identifying Social Barriers to Health Literacy in ESRD Patients Undergoing Kidney Transplant Evaluation.

    K. Leick,1 J. Jones,1 S. Witte,2 L. Hunsicker,3 Z. Stewart.1

    1Dept of Surgery, University of Iowa, Iowa City, IA; 2Dept of Social Work, University of Iowa, Iowa City, IA; 3Dept of Internal Medicine, University of Iowa, Iowa City, IA.

    Background: Low health literacy is associated with increased hospitalizations and mortality. ESRD patients have reduced health literacy as ESRD disproportionately affects the elderly and individuals…
  • 2016 American Transplant Congress

    Transplants without Borders – A Project for In Locus Training of New Transplants Centers in Brazil.

    M. Perosa,1 J. Branez,1 L. Mota,1 B. Zeballos,1 H. Noujaim,1 L. Ianhez,1 L. Alvim,1 D. Machado,1 M. Moreno,1 T. Genzini,1 R. Kandaswamy.2

    1Transplant Department, Bandeirantes Hospital, Sao Paulo, SP, Brazil; 2Transplant, Univ Minnesota, Minneapolis, MN.

    The regional disparity in transplant activity is a huge problem in Brazil and in other countries. Brazilian transplant centers are concentrated in the coastal states,…
  • 2016 American Transplant Congress

    Deceased Organ Donor Factors Influencing Pancreatic Graft Transplantation and Survival.

    M. Sally, M. Ellis, T. Groat, X. Gao, S. De la Cruz, M. Patel, D. Malinoski.

    Section of Critical Care, Portland VA Health Care System, Portland, OR.

    Criteria for organ acceptance remain inconsistent in pancreatic transplantation. The lack of predictive criteria limits the ability to standardize critical care practices in management of…
  • 2016 American Transplant Congress

    A Comprehensive Biomarker Study to Compare Tacrolimus and Mycophenolic Acid versus Half-Dose Tacrolimus and Everolimus in De Novo Kidney Transplant Patients in the Novartis US92 Study.

    J. Klepacki,1 J. Klawitter,1 J. Klawitter,1 A. Karimpour-fard,2 E. Anderson,1 G. Ingle,3 D. Patel,3 K. Johnson,4 D. Cibrik,4 U. Christians.1

    1University of Colorado Denver, Aurora, CO; 2University of Colorado Denver, Aurora, CO; 3Novartis Pharmaceuticals, East Hannover, NJ; 4University of Michigan, Ann Arbor, MI.

    In this exploratory biomarker sub-study, a comprehensive combined targeted/ non-targeted metabolomics and targeted proteomics approach was used to assess potential differences between the everolimus+ low-dose…
  • 2016 American Transplant Congress

    Pediatric Patients Benifit from Steroids Free Regimen After Kidney Transplantation: A Meta-Analysis.

    R. Deng, H. Zhang, Y. Zheng, L. Liu, C. Wang.

    Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

    Objective: To evaluate the effect of steroids avoidance or withdrawal (SAW) protocol on pediatric recipients by performing a meta-analysis of randomized controlled trials (RCTs).Method: A…
  • 2016 American Transplant Congress

    Outcome of the Various Pathology Grades of Antibody-Mediated Rejection After Heart Transplantation.

    J. Patel, M. Kittleson, D. Chang, T. Aintablian, L. Czer, A. Trento, J. Kobashigawa.

    Cedars-Sinai Heart Institute, Los Angeles, CA.

    Background: The pathology scale for antibody-mediated rejection (AMR) was approved by the board of directors in 2013. The ISHLT AMR grading scale consists of pAMR…
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