2016 American Transplant Congress
The Impact of CMS Policy on Delisting of "Too Sick" Liver Transplant Candidates.
Surgery, UMass Medical School, Worcester, MA.
Background: The Model for End Stage Liver Disease (MELD)-based allocation system (2002) transformed liver transplant waitlist mortality by prioritizing the “sickest first.” We examine the…2016 American Transplant Congress
Designing a Novel Highly Selective Immunoproteasome Inhibitor That Promotes Longterm Heart Allograft Acceptance While Inducing Immune Cell Exhaustion, Treg Induction and Memory Cell Suppression.
The constitutive Proteasomes (c-20S) are ubiquitously expressed cellular proteases that degrade polyubiquitinated proteins and regulate cell functions. However, immunoproteasomes (IP or i-20S) are primarily expressed…2016 American Transplant Congress
Ageing as a Barrier to Transplant Tolerance.
Surgery/Transplant, Massachusetts General Hospital, Harvard Medical, Boston, MA.
We recently demonstrated that ageing also impedes development of transplantation tolerance. Unlike their young counterparts (8-12 weeks of age) aged male recipients (greater than 12…2016 American Transplant Congress
The Largest Single Center Experience with Total Artificial Heart Implantation: Characterization of Outcome.
Cedars-Sinai Heart Institute, Los Angeles, CA.
Background: Patients with severe irreversible biventricular heart failure may require support with the total artificial heart (TAH). These patients are usually Intermacs level 1 or…2016 American Transplant Congress
Is Facilitated Pancreas Allocation Effective?
Background: OPTN policy exists that allows the UNOS Organ Center to facilitate the allocation of a pancreas within 1 hr. of donor surgery, permissible only…2016 American Transplant Congress
Selective Deletion of Notch2 on B Cells Abrogates Alloantibody Production in Fully MHC-Mismatched Cardiac and Skin Transplant Models.
Alloantibody-mediated injury remains a major challenge for the improvement of long-term graft survival and there is no effective therapy to prevent alloantibody generation post-transplant. The…2016 American Transplant Congress
The 20S Proteasome, Active within Exosome-Like Vesicles Released by Apoptotic Cells Accelerates Rejection.
Apoptotic bodies (ApoBodies) and apoptotic exosome-like MV (ApoExo) released by apoptotic endothelial cells in vitro were purified by sequential centrifugation and analysed by electron microscopy…2016 American Transplant Congress
Pre-Transplant Infusion of Extracorporeal Photopheresis Treated Donor Splenocytes Leads to Long-Term Liver Allograft Survival and Donor Specific Tolerance in Rats.
Extracorporeal photopheresis (ECP), a procedure that exposes isolated WBC to photoactivatable 8-methoxypsoralen and ultraviolet A radiation, is used clinically to treat patients with cutaneous T-cell…2016 American Transplant Congress
Early Hospital Readmission Following Pediatric Kidney Transplantation.
Surgery, Johns Hopkins University, School of Medicine, Baltimore, MD.
BACKGROUND: Approximately 31% of all adult kidney transplant (KT) recipients experience early hospital readmission and it is associated with inferior post-KT survival. Given the significant…2016 American Transplant Congress
Offering HCV-Positive Kidneys to HCV-Negative Patients on the Kidney Transplant Waitlist Is Lifesaving: Results of a Markov Model.
Medicine, University of Pennsylvania, Philadelphia, PA.
Background: Patients with ESRD on the transplant waitlist face substantial risks of dying without a transplant. Because 2/3 of kidneys from hepatitis C virus (HCV)-positive…
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