Am J Transplant, Volume 16, Suppl 3 Archives - Page 3 of 180 - ATC Abstracts

2016 American Transplant Congress
6 Minute Walk Test and FVC Analysis: A New Method to Prioritize Organ Allocation for Patients with COPD.
I. Timofte, M. Terrin, M. Wijesinha, P. Sanchez, R. Pierson, E. Barr, J. Kim, Z. Kon, S. Pham, A. Iacono.
University of Maryland, Baltimore, MD.
Purpose: Lung transplantation remains the final therapeutic option for patients with end stage lung disease. COPD being one of the most severe common lung diseases…
2016 American Transplant Congress
Inconsistent HLA Antibody Reactivity Detected with Different Solid-Phase Assays.
A. Jaramillo,¹ L. Nelson,¹ Y. Desmarteau,¹ B. Labuda,² K. Barrios,² J. Lunz,² R. Heilman,³ M. Pando.¹
¹Department of Laboratory Medicine and Pathology, Mayo Clinic, Phoenix, AZ; ²Gift of Hope Organ & Tissue Donor Network, Itasca, IL; ³Department of Medicine, Mayo Clinic, Phoenix, AZ.
Precise determination of HLA antibodies is essential for patients awaiting transplantation. HLA antigens that are recognized by a patient are listed in UNOS as unacceptable…
2016 American Transplant Congress
Preformed Antibodies Against AT₁R and EDNRA Correlate with Rejection Post-Transplant.
A. Gareau,¹ C. Wiebe,^1,2 D. Pochinco,² I. Gibson,³ D. Rush,¹ P. Nickerson.^1,2,4
¹Internal Medicine, University of Manitoba, Winnipeg, MB, Canada; ²Diagnostic Services of Manitoba, Winnipeg, MB, Canada; ³Pathology, University of Manitoba, Winnipeg, MB, Canada; ⁴Immunology, University of Manitoba, Winnipeg, MB, Canada.
Studies have investigated the potential pathogenic effects of non-HLA antibodies (Ab), with a few reporting that Ab against the angiotensin II type 1 receptor (AT1R)…
2016 American Transplant Congress
Pharmakokinetics of Prolonged-Release Formulation of Tacrolimus: Comparison of AUC0-24 and Concentration at 10 Time Points.
K. Unagami,¹ M. Okumi,² M. Furusawa,² T. Hirai,² T. Shimizu,² K. Omoto,² M. Inui,² H. Ishida,² K. Nitta,¹ K. Tanabe.²
¹Nephrology, Tokyo Women's Medical University, Tokyo, Japan; ²Urology, Tokyo Women's Medical University, Tokyo, Japan.
Background:Use of an appropriate immunosuppressant is necessary for good graft survival in kidney transplantation (KTx). Currently, a prolonged-release formulation of tacrolimus (Graceptor or Adovagraf, Astellas…
2016 American Transplant Congress
A Prospective Randomized Study to Evaluate the Efficacy and Safety of Rabbit Antithymocyte Globulin (rATG) 3mg/Kg vs. 6mg/Kg in Kidney Transplant Patients Under Minimization Maintenance Immunosuppressive Regimen.
T. Sandes-Freitas, J. Junqueira Junior, M. Oliveira, C. Girão, R. Esmeraldo.
Hospital Geral de Fortaleza, Fortaleza, Brazil.
Background: rATG dosed from 4.5 to 7.5mg/kg has been the standard of care in most transplant centers. Recent studies have demonstrated similar efficacy with doses…
2016 American Transplant Congress
Development of an Integrated Transplant Data Mart for Customized Data Reporting.
R. Patzer, K. Little, J. Kirsch, J. Weaver, A. Adams.
Emory University, Atlanta.
Background: Transplant centers have a large amount of clinical data from multiple data sources that are utilized for quality tracking of clinical outcomes, regulatory reports,…
2016 American Transplant Congress
Immunosuppressive Actions of CLI95 and CORM401 on TLR4 in Renal Ischemia Reperfusion Injury.
P. Luke,^1,2,5 G. Cepinskas,^1,4 H. Alharbi,^3,5 A. Haig,^3,5 R. Bhattacharjee.^1,2,5
¹Matthew Mailing Centre, London Health Sciences Centre, London, Canada; ²Surgery, Western University, London, Canada; ³Pathology and Laboratory Medicine, Western University, London, Canada.
Background: Kidneys from all donor sources are highly sensitive to ischemia-reperfusion injury (IRI). However, grafts donated after cardiac death (DCD) sustain an increased incidence of…
2016 American Transplant Congress
Replacing Cold Storage with Normothermic Ex Vivo Kidney Perfusion Improves Function of Grafts Retrieved After Circulatory Death (DCD).
J. Kaths,^1,2 Y.-M. Chun,¹ D. Cen,¹ J. Echeverri,¹ I. Linares,¹ P. Yip,³ R. John,³ D. Bagli,⁴ I. Mucsi,⁵ A. Ghanekar,¹ D. Grant,¹ L. Robinson,² M. Selzner.¹
¹Department of Surgery, Multi Organ Transplant Program, Toronto General Hospital, University Health Network, Toronto, ON, Canada; ²Division of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada; ³Laboratory Medicine & Pathobiology, Toronto General Hospital, Toronto, ON, Canada; ⁴Departments of Surgery (Urology) & Physiology, The Hospital for Sick Children, Toronto, ON, Canada; ⁵Department of Medicine, Multi Organ Transplant Program, Toronto General Hospital, University Health Network, Toronto, ON, Canada.
Normothermic ex vivo kidney perfusion (NEVKP) and avoidance of static cold storage (SCS) is an attractive strategy to minimize injury of DCD kidney grafts. We…
2016 American Transplant Congress
An Improved Flow Cytometry Based Platelet Counting in Xeno Perfusion Models.
S. Sendil,¹ G. Braileanu,¹ W. Sun,¹ W. Hassanein,¹ D. Parsell,¹ H. Crum,² L. Burdorf,¹ R. Pierson,¹ A. Azimzadeh.¹
¹Department of Surgery, University of Maryland School of Medicine, Baltimore, MD; ²VA Medical Center, Baltimore, MD.
Aim: Human or baboon platelet sequestration and activation occurs during pig organ xenograft perfusion; its mechanism remains poorly understood. In the context of a regimen…
2016 American Transplant Congress
Post-Donation eGFR and Hypertension in Living Kidney Donors.
A. Massie,¹ A. Muzaale,¹ S. Anjum,¹ J. Leanza,¹ J. Alejo,¹ J. Locke,² D. Segev.¹
¹JHU, Baltimore; ²University of Alabama, Birmingham, Birmingham.
Donor eGFR declines sharply after living kidney donation, but long-term eGFR trajectories and their relationship to post-donation hypertension are poorly understood.METHODS: We retrospectively obtained 7805…