ATC Abstracts

American Transplant Congress abstracts

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  • 2016 American Transplant Congress

    Replicative Senescence and Arteriosclerosis After Kidney Transplantation.

    K. De Vusser,1 D. Martens,2 E. Lerut,3 D. Kuypers,1 T. Nawrot,2 M. Naesens.1

    1Department of Nephrology and Renal Transplantation, UZ Leuven, Leuven, Belgium; 2Department of Imaging and Pathology, KULeuven, Leuven, Belgium; 3Centre for Environmental Sciences, U Hasselt, Hasselt, Belgium.

    BackgroundReplicative senescence is associated with telomere shortening. In native kidneys, obtained prior to transplantation, we recently described and validated a significant association between shorter intrarenal…
  • 2016 American Transplant Congress

    Same Policy, Different Impact: Center and Regional Effects of SHARE 35 Liver Allocation.

    D. Murken,1 A. Peng,1 D. Aufhauser Jr,1 D. Goldberg,2 M. Levine.1

    1Surgery, University of Pennsylvania, Philadelphia, PA; 2Medicine, University of Pennsylvania, Philadelphia, PA.

    Introduction: Early studies of national data suggest that Share-35 implementation was associated with more liver transplants, fewer discards, and lower waitlist mortality, without worsening of…
  • 2016 American Transplant Congress

    Factors Associated with Increased Risk of MELD Progression Among a Large Population of Patients with Cirrhosis and an Initial Low MELD Score (<15).

    K. Atiemo, L. Zhao, A. Skaro, L. VanWagner, S. Goel, A. Kho, B. Ho, R. Kang, S. Montag, J. Holl, M. Abecassis, D. Ladner.

    Northwestern University, Chicago.

    AimsLiving donor liver transplantation (LDLT) is an underutilized resource. Timely identification of patients with cirrhosis and a low MELD who's MELD score is likely to…
  • 2016 American Transplant Congress

    Risk Factors for Short and Long Term Mortality in High MELD Recipients.

    A. Bertacco,1,2 M. Rodriguez-Davalos,1 M. Schilsky,3 P. Yoo,1 S. Kulkarni,1 B. Fortune,3 A. Liapakis,3 S. Emre,1 D. Mulligan.1

    1Surgery, Yale University, New Haven; 2Dipartimento di Scienze Chirurgiche Oncologiche e Gastroenterologiche - DiSCOG, Padova University, Padova, Italy; 3Yale New Haven Transplant Center, Yale University, New Haven.

    The model for end-stage disease (MELD) score is used to stratify candidates for liver transplant (LT) based on objective measures. Since June 2013 with changes…
  • 2016 American Transplant Congress

    The Effect of Body Mass Index on Lung Transplant Outcomes.

    M. Kashem,1 A. Shiose,1 J. Abraham,1 N. Dean,1 S. Breves,1 F. Cordova,2 N. Patel,2 T. Yoshizumi,1 G. Criner,2 Y. Toyoda.1

    1Division of Cardiovascular Surgery, Temple University, Philadelphia, PA; 2Department of Thoracic Medicine and Surgery, Temple University, Philadelphia, PA.

    Background: Lung transplant (LTx) has the potential to effectively extend the life expectancy for patients with end-stage lung disease. Both high and low body mass…
  • 2016 American Transplant Congress

    Randomized Controlled Trial of Mixed Acute Rejection Therapy in Renal Allografts: 3 Year Follow Up.

    A. Leino,1 A. Lichvar,1 B. Abu-Jawdeh,1 A. Govil,1 G. Mogilishetty,1 M. Cardi,2 J. Kremer,2 M. Cuffy,1 F. Paterno,1 R. Alloway,1 A. Shields,1,2 E. Woodle.1

    1U. of Cincinnati, Cincinnati; 2The Christ Hospital, Cincinnati.

    Optimal therapy for mixed acute rejection (MAR) (defined as coexisting acute cellular and antibody mediated rejection) has not been defined. Rabbit antithymocyte globulin (rATG) has…
  • 2016 American Transplant Congress

    Comparison of EDTA, DTT and Dilutions to Abrogate the Prozone Effect in Luminex-Based HLA Antibody Assays.

    M. Pando, S. Franklin, L. Nelson, Y. Desmarteau, A. Jaramillo.

    Department of Laboratory Medicine and Pathology, Mayo Clinic, Phoenix, AZ.

    Mean fluorescence intensity (MFI) values obtained from Luminex-based single antigen bead (SAB) assays is a semi-quantitative result used to determine the relative strength of HLA…
  • 2016 American Transplant Congress

    Breadth of HLA-Specific B Cell Reactivity and Frequency Assessed by a Novel Multiplex Bead Based Assay Predicts and Correlates with Rejection in Kidney Transplant Recipients.

    A. Akl, Z. Ilyas, O. Traitanon, L. Gallon, A. Tambur, M. Ansari.

    Northwestern University, Chicago.

    Introduction: Recipients with broad sensitization to HLA defined by a high percentage of Panel Reactive Antibodies (PRA) are at higher immunologic risk for poor graft…
  • 2016 American Transplant Congress

    Alemtuzumab Induction Allows Better Rejection Free Graft Survival in Comparison to Basiliximab Although with Increased Post Transplant Viral Infections.

    V. Siddagangaiah,1 H. Sharma,2 N. Lal,1 J. Rai,1 M. Howse,1 D. Ridgway,1 A. Sharma,1 A. Hammad,1 S. Mehra.1

    1Renal Transplant Surgery, Royal Liverpool and Broadgreen University Hospital, Liverpool, United Kingdom; 2Transplant Surgery, Manchester Royal Infirmary, Manchester, United Kingdom.

    Introduction: 3C study concluded that in comparison to basiliximab, alemtuzumab induction reduces the risk of biopsy proven acute rejection (BPAR) in renal transplant recipients. In…
  • 2016 American Transplant Congress

    Thoracic Simulated Allocation Modeling (TSAM) of Broader Sharing.

    M. Colvin,1 M. Skeans,1 L. Robbins Callahan,2 L. Edwards,2 J. Zeglin,1 S. Silvestry,3 R. Davies,4 M. Farr,5 A. Israni,1 J. Rogers.6

    1SRTR, Minneapolis, MN; 2UNOS, Richmond, VA; 3Florida Hospital Transplant Institute, Orlando, FL; 4Nemours/A.I. duPont Hospital for Children, Wilmington, DE; 5Columbia University Medical Center, New York, NY; 6Duke University, Durham, NC.

    Heart allocation policy (OPTN policy 6) is in development. The Heart Subcommittee of the OPTN Thoracic Committee developed a 6-tiered medical urgency algorithm, then investigated…
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