Am J Transplant, Volume 16, Suppl 3 Archives - Page 170 of 180 - ATC Abstracts

2016 American Transplant Congress
Immunogenic HLA-DR Eplet Mismatches as Predictors of Transplant Glomerulopathy.
D. Blum,¹ K. Tinckam,² M. Marrari,³ J. Kim,² R. Sapir-Pichhadze.¹
¹McGill University, Montreal, Canada; ²University Health Network, Toronto, Canada; ³University of Pittsburgh Medical Center, Pittsburgh.
BackgroundThe number of HLA-DR eplet mismatches (eplet load) is a risk factor for the development of anti-HLA antibodies and transplant glomerulopathy (TG). In the case…
2016 American Transplant Congress
Reversibility of Acute Kidney Rejection According to the Banff 2013 Classification: A Retrospective Cohort Study.
A. Poulin,¹ M. Dorais,² L. Sénécal,³ S. Colette,³ H. Cardinal.¹
¹CRCHUM, Montreal, QC, Canada; ²Statsciences, Montreal, QC, Canada; ³HMR, Montreal, QC, Canada.
Background: Vascular involvement of the allograft has classically been regarded as a poor prognostic factor in acute kidney graft rejection. Cell-mediated endarteritis often coexists with…
2016 American Transplant Congress
YKL-40 Predicts Renal Recovery in Deceased-Donor Transplantation.
J. Puthumana,¹ I. Hall,¹ P. Reese,² B. Schröppel,³ F. Weng,⁴ H. Thiessen-Philbrook,¹ M. Doshi,⁵ V. Rao,¹ C. Lee,⁶ J. Elias,⁶ L. Cantley,¹ C. Parikh.¹
¹Yale University School of Medicine, New Haven, CT; ²Renal-Electrolyte and Hypertension Division, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; ³Section of Nephrology, University Hospital, Ulm, Germany; ⁴Saint Barnabas Medical Center, Livingston, NJ; ⁵Division of Nephrology, Wayne State University School of Medicine, Detroit, MI; ⁶School of Medicine and Biological Sciences, Brown University, Providence, RI.
Background Deceased-donor kidneys with acute kidney injury (AKI) are often discarded for fear of poor transplantation outcomes. Donor biomarkers that predict post-transplant renal recovery could…
2016 American Transplant Congress
Analysis of Local versus Imported Expanded Criteria Donor (ECD) Kidneys: A Single Center Experience with 497 ECD Kidney Transplants.
M. Khan,¹ H. El-Hennawy,¹ A. Farney,¹ J. Rogers,¹ G. Orlando,¹ A. Reeves-Daniel,² A. Palanisamy,² M. Gautreaux,³ S. Iskandar,³ W. Doares,⁴ S. Kaczmorski,⁴ R. Stratta.¹
¹Surgery, Wake Forest, Winston-Salem, NC; ²Internal Medicine, Wake Forest, Winston-Salem, NC; ³Pathology, Wake Forest, Winston-Salem, NC; ⁴Pharmacy, Wake Forest, Winston-Salem, NC.
With the new Kidney Allocation System, broader sharing of expanded criteria donor (ECD) kidneys may occur, which may influence discard rates and survival outcomes. To…
2016 American Transplant Congress
Regression of Asymptomatic Cardiomyopathy and Clinical Outcome of Renal Transplant Recipients: Long-Term Extension of Two Randomized Controlled Trials.
E. Paoletti, D. Bellino, L. Marsano, R. Russo, F. Masarino, G. Garibotto.
Nephrology, Dialysis, and Transplantation, University of Genoa, Genoa, Italy.
Background Asymptomatic left ventricular hypertrophy (LVH) is highly prevalent and associated with adverse outcome in renal transplant recipients (RTRs). Nonetheless, there are currently no available…
2016 American Transplant Congress
Heparanase: A New Factor Involved in the Pro-Fibrotic Renal Biological Machinery Activated by the Ischemia/Reperfusion (I/R) Injury.
G. Zaza,¹ V. Masola,¹ G. Gambaro,² M. Onisto,³ G. Bellin,¹ I. Vlodavsky,⁴ Z. Abassi,⁵ A. Lupo.¹
¹Renal Unit, Department of Medicine, University of Verona, Verona, Italy; ²Division of Nephrology and Dialysis, Columbus-Gemelli Hospital Catholic University, Rome, Italy; ³Department of Biomedical Sciences, University of Padova, Padova, Italy; ⁴Cancer and Vascular Biology Research Center, Rappapor Faculty of Medicine, Technion, Haifa, Israel, Italy; ⁵Department of Physiology and Biophysics, Rappaport Faculty of Medicine, Technion, Haifa, Israel, Italy.
Ischemia/reperfusion (I/R) is an important cause of acute renal failure and delayed graft function, and it may induce chronic renal damage by activating epithelial to…
2016 American Transplant Congress
The Role of HLA Class II Antibody in Endothelial Cell Activation and Allograft Rejection.
G. Cantanhede,¹ V. Carter,² K. Giles,² J. Kirby,¹ S. Ali.¹
¹Institute of Cellular Medicine, University of Newcastle, Newcastle, Tyne and Wear, United Kingdom; ²Histocompatibility and Immunogenetics, National Health Service Blood and Transplant, Newcastle, Tyne and Wear, United Kingdom.
Background: Antibody-mediated rejection is one of the major causes of chronic rejection. This is mediated by endothelial cell activation, a process of endothelium microvascular inflammation…
2016 American Transplant Congress
Contributions of Naive vs. Endogenous and Induced Alloreactive Memory T Cells in Mixed Lymphocyte Reactions.
J. Lee, G. Benichou.
Surgery, MGH/Harvard Medical School, Boston, MA.
T lymphocytes isolated from naïve, unmanipulated mice, proliferate and secrete cytokines when cultured in vitro with allogeneic irradiated leukocytes. This in vitro response known as…
2016 American Transplant Congress
Adiponectin Is Produced by Leukocytes Infiltrating Renal Transplants.
S. Goparaju, R. Fan, K. Keslar, N. Dvorina, W. Baldwin III.
Immunology, Cleveland Clinic, Cleveland, OH.
Fat is now recognized as a source of immunologically significant cytokines. Adiponectin, the most abundant adipokine, is usually classified as an anti-inflammatory cytokine because decreased…
2016 American Transplant Congress
Virtual Crossmatch in Simultaneous Pancreas-Kidney Transplant.
E. Bevilaqua Rangel,¹ A. Miziara Gonzalez,¹ C. Santiago Melaragno,¹ J. de Sa,¹ M. Moura Linhares,¹ A. Salzedas-Neto,¹ R. de Marco,² M. de Lima,² J. Medina-Pestana.¹
¹Transplant Unit, Federal University of Sao Paulo, Sao Paulo, SP, Brazil; ²Histocompatibility Laboratory, Federal University of Sao Paulo, Sao Paulo, Brazil.
Background: Simultaneous pancreas-kidney transplant (SPKT) outcomes have improved over the years. Methods: Analyses of demographic data of patients submitted to SPKT from Dec/2000 to Sep/2015…