ATC Abstracts

American Transplant Congress abstracts

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  • 2016 American Transplant Congress

    Regression of Asymptomatic Cardiomyopathy and Clinical Outcome of Renal Transplant Recipients: Long-Term Extension of Two Randomized Controlled Trials.

    E. Paoletti, D. Bellino, L. Marsano, R. Russo, F. Masarino, G. Garibotto.

    Nephrology, Dialysis, and Transplantation, University of Genoa, Genoa, Italy.

    Background Asymptomatic left ventricular hypertrophy (LVH) is highly prevalent and associated with adverse outcome in renal transplant recipients (RTRs). Nonetheless, there are currently no available…
  • 2016 American Transplant Congress

    Heparanase: A New Factor Involved in the Pro-Fibrotic Renal Biological Machinery Activated by the Ischemia/Reperfusion (I/R) Injury.

    G. Zaza,1 V. Masola,1 G. Gambaro,2 M. Onisto,3 G. Bellin,1 I. Vlodavsky,4 Z. Abassi,5 A. Lupo.1

    1Renal Unit, Department of Medicine, University of Verona, Verona, Italy; 2Division of Nephrology and Dialysis, Columbus-Gemelli Hospital Catholic University, Rome, Italy; 3Department of Biomedical Sciences, University of Padova, Padova, Italy; 4Cancer and Vascular Biology Research Center, Rappapor Faculty of Medicine, Technion, Haifa, Israel, Italy; 5Department of Physiology and Biophysics, Rappaport Faculty of Medicine, Technion, Haifa, Israel, Italy.

    Ischemia/reperfusion (I/R) is an important cause of acute renal failure and delayed graft function, and it may induce chronic renal damage by activating epithelial to…
  • 2016 American Transplant Congress

    The Role of HLA Class II Antibody in Endothelial Cell Activation and Allograft Rejection.

    G. Cantanhede,1 V. Carter,2 K. Giles,2 J. Kirby,1 S. Ali.1

    1Institute of Cellular Medicine, University of Newcastle, Newcastle, Tyne and Wear, United Kingdom; 2Histocompatibility and Immunogenetics, National Health Service Blood and Transplant, Newcastle, Tyne and Wear, United Kingdom.

    Background: Antibody-mediated rejection is one of the major causes of chronic rejection. This is mediated by endothelial cell activation, a process of endothelium microvascular inflammation…
  • 2016 American Transplant Congress

    Contributions of Naive vs. Endogenous and Induced Alloreactive Memory T Cells in Mixed Lymphocyte Reactions.

    J. Lee, G. Benichou.

    Surgery, MGH/Harvard Medical School, Boston, MA.

    T lymphocytes isolated from naïve, unmanipulated mice, proliferate and secrete cytokines when cultured in vitro with allogeneic irradiated leukocytes. This in vitro response known as…
  • 2016 American Transplant Congress

    Adiponectin Is Produced by Leukocytes Infiltrating Renal Transplants.

    S. Goparaju, R. Fan, K. Keslar, N. Dvorina, W. Baldwin III.

    Immunology, Cleveland Clinic, Cleveland, OH.

    Fat is now recognized as a source of immunologically significant cytokines. Adiponectin, the most abundant adipokine, is usually classified as an anti-inflammatory cytokine because decreased…
  • 2016 American Transplant Congress

    Virtual Crossmatch in Simultaneous Pancreas-Kidney Transplant.

    E. Bevilaqua Rangel,1 A. Miziara Gonzalez,1 C. Santiago Melaragno,1 J. de Sa,1 M. Moura Linhares,1 A. Salzedas-Neto,1 R. de Marco,2 M. de Lima,2 J. Medina-Pestana.1

    1Transplant Unit, Federal University of Sao Paulo, Sao Paulo, SP, Brazil; 2Histocompatibility Laboratory, Federal University of Sao Paulo, Sao Paulo, Brazil.

    Background: Simultaneous pancreas-kidney transplant (SPKT) outcomes have improved over the years. Methods: Analyses of demographic data of patients submitted to SPKT from Dec/2000 to Sep/2015…
  • 2016 American Transplant Congress

    MicroRNA-375 and -200c Are a Set of Novel Biomarkers That Can Predict Islet Autotransplantation Outcome.

    G. Yoshimatsu,1 M. Kanak,2 M. Takita,1 S. Prathab Balaji,1 C. Chang,1 M. Lawrence,1 M. Levy,2 N. Onaca,3 P. Kim,3 B. Naziruddin.3

    1Islet Cell Laboratory, Baylor Research Institute, Dallas, TX; 2Transplant Division, Department of Surgery, VCU Medical Center, Richmond, VA; 3Baylor Simmons Transplant Institute, Dallas, TX.

    Introduction: Total pancreatectomy with islet autotransplantation (TPIAT) is an effective treatment for refractive chronic pancreatitis to relieve pain and retain endocrine function. Patient selection is…
  • 2016 American Transplant Congress

    Rapamycin (RPM) Synergizes with CD154 mAb and DST to Promote Long-Term Vascularized Composite Allograft (VCA) Survival, but Prevents Induction of Donor-Specific Tolerance.

    L. Wang, Z. Wang, R. Han, T. Bhatti, L. Levin, M. Levine, W. Hancock.

    CHOP & UPenn, Philadelphia.

    Even though CD154 mAb (MR-1) plus donor splenocyte transfusion (DST) is very effective at inducing tolerance of various allografts, such as those of hearts, kidneys…
  • 2016 American Transplant Congress

    Zero and One Mismathing for HLA DR10,14,16 Produces Increased Kidney Graft Survival.

    J. Cicciarelli,1,2 Y. Cho,2 M. Altrich,1 N. Kasahara,1,3 N. Lemp.1

    1Viracor-IBT HLA Lab, Viracor-IBT Laboratories, Los Angeles, CA; 2USC Keck School of Medicine, Los Angeles, CA; 3University of Miami, Miami, FL.

    Aims: HLA DR matching has shown measureable significant effects in kidney graft survival. Part and parcel of this association is the HLA Class II allele…
  • 2016 American Transplant Congress

    Clinical Outcome of Elderly Living Kidney Donors: A Single-Center Study in Japan.

    J. Hasegawa, K. Unagami, M. Okumi, K. Omoto, M. Inui, H. Ishida, K. Tanabe.

    Urology, Tokyo Women's Medical University, Tokyo, Japan.

    Background: Previous studies and current guidelines have suggested that elderly persons can be living kidney donors; however, reports on elderly donors >70 years old are…
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