Am J Transplant, Volume 16, Suppl 3 Archives - Page 165 of 180 - ATC Abstracts

2016 American Transplant Congress
T-Bet Regulates nTreg Stability and Suppression in an Islet Allograft Model.
Y. Xiong, S. Ahmad, D. Iwami, C. Brinkman, J. Bromberg.
University of Maryland, Baltimore.
The transcription factor T-bet endows Treg with properties tosuppress Th1 inflammation. However, the mechanisms by which T-bet controls alloimmune responses are not fully understood. We…
2016 American Transplant Congress
A Novel Murine Orthotopic Forelimb Transplantation Model That Allows for Reliable Assessment of Post-Transplant Upper Extremity Function.
J. Budihardjo,¹ B. Kern,^1,2 S. Mermulla,¹ A. Quan,¹ C. Cadmi,¹ J. Lopez,¹ J. Park,¹ A. Hoke,¹ W. Lee,¹ S. Tuffaha,¹ G. Brandacher.¹
¹Plastic Surgery, Johns Hopkins Medical Institutions, Baltimore, MD; ²Transplant Surgery, Medical University of Innsbruck, Innsbruck, Austria.
Background: Studies related to functional return for upper extremity transplantation have been limited by the lack of a functional VCA animal model. The rat hindlimb…
2016 American Transplant Congress
The Role of PI3kγ and PI3kδ in Alloimmunity.
M. Uehara,¹ A. Jamil,¹ Z. Solhjou,¹ M. McGrath,¹ N. Banouni,¹ C. Evans,² J. Dinitto,² D. Winkler,² R. Abdi.¹
¹Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; ²Infinity Pharmaceuticals, Inc, Boston.
We studied the role of phosphatidylinositol-3-kinases (PI3k) γ and δ pathway in alloimmunity. Generated Foxp3-GFP-PI3kγ and -PI3kδ knockout mice (C57BL/6 background) were used in heart…
2016 American Transplant Congress
Aquaporin 4 Blockade Is a Novel Strategy to Prevent T Cell Activation and Effector Functions.
K. Ayasoufi,¹ N. Kohei,¹ G. Farr,² P. McGuirk,² M. Pelletier,² R. Fairchild,¹ A. Valujskikh.¹
¹Cleveland Clinic, Cleveland; ²Aeromics LLC, Cleveland.
Aquaporin 4 (AQP4) belongs to the family of integral transmembrane proteins highly permeable to water. We have previously reported that blocking AQP4 with small molecule…
2016 American Transplant Congress
Colonization and Risk of Bacteremia by Multi-Drug Resistant Organisms in Intestinal Transplant Recipients.
J. Simkins,¹ J. Camargo,¹ M. Morris,¹ R. Vianna,² T. Beduschi,² L. Abbo.¹
¹Medicine/Infectious Diseases, University of Miami Miller School of Medicine, Miami, FL; ²Surgery, Miami Transplant Institute/University of Miami, Miami, FL.
Background: This study is the first to evaluate colonization rates and subsequent bacteremia with multi-drug resistant organisms (MDRO) in intestinal transplant (ITx) recipients.Methods: Retrospective study…
2016 American Transplant Congress
When Living Donor Liver Allografts Fail: Exploring the Pitfalls of Retransplantation Using Deceased Donor Organs.
T. Bittermann,¹ A. Shaked,² K. Lloyd,² D. Goldberg.¹
¹Gastroenterology and Hepatology, University of Pennsylvania, Philadelphia, PA; ²Transplant Surgery, University of Pennsylvania, Philadelphia, PA.
Background: In the US, living donor liver transplantation (LDLT) is associated with increased long-term graft and patient survival compared to deceased donor liver transplantation (DDLT).…
2016 American Transplant Congress
Short UK Dialysis Does Not Significantly Impact on Live Donor Kidney Allograft Survival.
A. Bentall,^1,2 M. Jesky,^1,2 R. Borrows,^1,2 R. Johnson,³ S. Ball.^1,2
¹Department of Nephrology, University Hospitals Birmingham, Birmingham, United Kingdom; ²School of Immunity and Infection, University of Birmingham, Birmingham, United Kingdom; ³NHSBT, Bristol, United Kingdom.
Background. The survival advantage of pre-emptive transplantation (Pre-empTx) in live donor kidney transplantation (LDKTx) was reported by Meier-Kreische (Kidney International, 2000). Dialysis practices differ internationally…
2016 American Transplant Congress
Earlier Repletion of Lymphocytes After Alemtuzumab Induction Is Associated with a Lower Incidence of Infection Following Renal Transplantation.
M. Willicombe, D. Goodall, A. McLean, D. Taube.
Imperial College Renal and Transplant Centre, Hammersmith Hospital, London, United Kingdom.
Introduction: Alemtuzumab has been increasingly used as an induction agent in renal transplantation, although the optimal dose is unknown. We have previously reported that alemtuzumab…
2016 American Transplant Congress
Twenty Years of Evolving Trends in Racial Disparities for Adult Kidney Transplant Recipients.
D. Taber, M. Gebregziabher, K. Chavin, T. Srinivas, P. Baliga, L. Egede.
Med Univ of South Carolina, Charleston, SC.
Objective: To determine if baseline risks and post-transplant outcome disparities in African American (AA) kidney transplant recipients have evolved over time.Methods: Analysis of 20-years of…
2016 American Transplant Congress
Exosomes with Lung Associated Self-Antigens (Collagen V and K alpha 1 Tubulin): Role in Rejection Following Human Lung Transplantation.
M. Gunasekaran,^1,2 Z. Xu,^1,2 D. Nayak,^1,2 M. Sharma,^1,2 R. Hachem,¹ T. Mohanakumar.^1,2
¹Surgery, Pathology & Immunology, & Medicine, Washington Univ Sch Med, St. Louis, MO; ²Norton Thoracic Institute - St. Joseph's Hospital, Phoenix, AZ.
Immune response to HLA and non-HLA antigens play a significant role in the development of chronic and acute rejection (AR), bronchiolitis obliterans syndrome (BOS), following…