ATC Abstracts

American Transplant Congress abstracts

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  • 2016 American Transplant Congress

    IL-2 Therapy Restores the Impaired Function of Regulatory T Cells Induced by Calcineurin Inhibitors in Liver Transplantation.

    G. Whitehouse, E. Gray, S. Mastoridis, E. Kodela, A. Sanchez-Fueyo, M. Martinez-Llordella.

    Liver Science Department, King's College London, London, United Kingdom.

    CD4+CD25+FOXP3+ regulatory T cells (Tregs) have an essential role in immune regulation and constitute a key target for cellular immunotherapies in transplantation. IL-2 is critical…
  • 2016 American Transplant Congress

    Long-Lasting Skin Allograft Tolerance Induced and Maintained by Short-Term Vascularized Bone Marrow Transplant in a Mouse Model.

    C.-H. Lin,1 M. Anggelia,1 H.-Y. Cheng,1 Y.-L. Wang,1 W.-Y. Chuang,1 C.-H. Lin,1 G. Brandacher.2

    1Center for Vascularized Composite Allotransplantation, Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 2Department of Plastic and Reconstructive Surgery, Vascularized Composite Allotransplantation (VCA) Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD.

    Background: Accumulating evidences indicate that vascularized bone marrow transplantation (VBMT) plays a critical role in inducing tolerance of vascularized composite allografts (VCA). Recipients with long-term…
  • 2016 American Transplant Congress

    Targeting IFN-g-Expressing TIM-4+ B Effector (Beff) Cells as a Novel Strategy to Prevent Allograft Rejection.

    Q. Ding,1 K. Mohib,1 S. Xiao,2 V. Kuchroo,2 D. Rothstein.1

    1University of Pittsburgh, Pittsburgh; 2Harvard Medical School, Boston.

    B cell depletion can augment or inhibit auto- and allo- immune responses in humans and mice without altering Ig levels. This is likely due to…
  • 2016 American Transplant Congress

    Mechanistic Insights into How Targeting of HDAC10 Promotes Foxp3+ Treg Cell Suppressive Activity, Gene Expression and Metabolism, and Enhances Allograft Survival.

    S. Dahiya,1 L. Wang,1 U. Beier,1,2 A. Angelin,1 R. Han,1 D. Wallace,1,2 W. Hancock.1,2

    1Children's Hospital of Philadelphia, Philadelphia; 2University of Pennsylvania, Philadelphia.

    Foxp3+ T-regulatory (Treg) cells are key regulators of immune responses that can result in unwarranted inflammation and promote allograft rejection. From a theoretical perspective, targeting…
  • 2016 American Transplant Congress

    Characteristics and Outcomes of Vancomycin Resistant Enterococcus Bacteremia After Liver Transplant.

    R. Odrobina,1 C. Kovacs,1 R. Butler,2 C. Koval.1

    1Department of Infectious Diseases, Cleveland Clinic, Cleveland, OH; 2Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH.

    Vancomycin Resistant Enterococcus (VRE) infection is reported in 5-20% of liver transplant (LT) recipients and is associated with decreased survival. Published data includes infections of…
  • 2016 American Transplant Congress

    Biliary Epithelial Damage, Regenerative Capacity and Local Immune Response After Cold Storage of DBD Livers Determine Biliary Complications After Liver Transplantation.

    S. Brunner, H. Junger, H. Schlitt, S. Fichtner-Feigl.

    Department of Surgery, University Medical Center Regensburg, Regensburg, Germany.

    Background: The aim of this study was to examine the development and molecular mechanisms of bile duct (BD) damage between organ retrieval and transplantation and…
  • 2016 American Transplant Congress

    Effect of mTOR Inhibitors on the Risk of Cancer Development After Kidney Transplantation in Chinese Population.

    C.-C. Kao,1 J.-S. Liu,2 M.-H. Lin,2 F.-C. Chang,1 Y.-C. Lin,1 H.-H. Chen,1 T.-W. Chen,1 C.-C. Hsu,2 M.-S. Wu.1

    1Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan; 2Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.

    Introduction The mTOR inhibitor is an immunosuppressive drug used in kidney transplantation. Whether the mTOR inhibitors is associated with reduced risk of cancer development in…
  • 2016 American Transplant Congress

    Everolimus (EVR) versus Mycophenolate Sodium (MPS) for Recipients of Kidney Transplants from Expanded Criteria Donors (ECD) Receiving Anti-Thymocyte Globulin (r-ATG) and Tacrolimus (TAC).

    H. Tedesco-Silva,1 C. Felipe,1 A. Brigido,1 A. Bessa,1 M. Paula,1 P. Ruppel,1 M. Cristelli,1 L. Viana,1 G. Basso,1 M. Franco,2 W. Aguiar,1 J. Medina-Pestana.1

    1Nephrology Division, Hospital do Rim - UNIFESP, Sao Paulo, Brazil; 2Pathology Division, UNIFESP, Sao Paulo, Brazil.

    Introduction: There is no standard of care immunosuppressive regimen for recipients of kidneys recovered from expanded criteria donors. Several centers use r-ATG induction due to…
  • 2016 American Transplant Congress

    Crisis on the Waiting List for Children Listed in Low Volume Solid Organ Transplant Centers.

    A. Rana, E. Brewer, W. Winkelmayer, C. O'mahony, J. Goss.

    Department of Abdominal Transplantation, Baylor College of Medicine, Houston, TX.

    Purpose: In a recent analysis, we demonstrated that children listed in low volume liver transplant centers had poor waitlist survival and a depressed transplant rate…
  • 2016 American Transplant Congress

    Utilization of HCV-Positive Donors' Kidneys: Potential Benefits in the Era of Direct Acting Antiviral (DAA) Therapy.

    B. Amundsen,1 M. Sise,2 M. Lin,3 H. Deirawan,1 E. Heher,2 B. Kimball,1 J. Markmann,1 N. Elias.1

    1Massachusetts General Hospital, Boston, MA; 2Massachusetts General Hospital, Boston, MA; 3Brigham and Women's Hospital, Boston, MA.

    Organ shortage and expanding kidney waiting list fostered utilization of HCV positive donors' organs (HCVD+). HCVD+ kidneys have slightly worse long term outcomes compared with…
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