Am J Transplant, Volume 16, Suppl 3 Archives - Page 15 of 180 - ATC Abstracts

2016 American Transplant Congress
Factors Associated with Mortality Among a Large Population of Patients with Cirrhosis and a Low MELD (<15).
K. Atiemo, L. Zhao, A. Skaro, L. VanWagner, S. Goel, A. Kho, B. Ho, R. Kang, S. Montag, J. Holl, M. Abecassis, D. Ladner.
Northwestern University, Chicago.
AimStudies suggest that certain patients with liver cirrhosis and a low MELD score (<15) remain at high risk for mortality. Current data is largely limited…
2016 American Transplant Congress
Erythropoietin (EPO) Mediates Spontaneous Kidney Transplant Tolerance in Mice.
P. Cravedi,¹ C. Purroy,¹ J. Madsen,² R. Fairchild,³ T. Tanaka,³ W. Baldwin 3rd,³ A. Alessandrini,² P. Heeger.¹
¹1Icahn School of Medicine at Mount Sinai, New York, NY; ²Transplantation Biology Research Center, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA; ³3Department of Immunology, Cleveland Clinic Foundation, Cleveland.
Spontaneous allogeneic kidney transplant tolerance occurs in mice, but the underlying mechanisms are unknown. Building upon recent human data showing that EPO, an erythropoietic hormone…
2016 American Transplant Congress
Combined CD122 and Costimulation Blockade Prolongs Allograft Survival by Controlling Expansion and Effector Function of Memory CD8 T Cells.
D. Mathews,¹ Y. Dong,¹ L. Higginbotham,¹ S. Kim,¹ C. Breeden,¹ J. Tso,² A. Adams.¹
¹Emory Transplant Center, Emory University, Atlanta, GA; ²JN Biosciences, Mountain View, CA.
CD8 memory T cells rely on signaling through CD122, the shared IL-2 and IL-15 receptor β-chain. The addition of anti-CD122 to costimulation blockade prolongs graft…
2016 American Transplant Congress
Dilution of Patient Sera Improves MFI Correlation with Complement Fixation in Solid Phase Assay Assessment.
C. Castleberry,¹ D. Phelan,² K. Simpson,¹ T. Mohanakumar,³ C. Canter.¹
¹Pediatric Cardiology, Washington University School of Medicine, St. Louis, MO; ²Histocompatibility Laboratory, Barnes-Jewish Hospital, St. Louis, MO; ³Surgery, Washington University School of Medicine, St. Louis, MO.
Background: Median Fluorescent Intensity (MFI) by solid phase assays (SPA) has been used to determine risk of donor-recipient reaction prior to transplant. Inconsistency of this…
2016 American Transplant Congress
NAD⁺Promotes Allograft Survival Independently of CD4⁺CD25⁺Foxp3⁺ Regulatory T Cells.
A. Elkhal, H. Rodriguez Cetina Biefer, H. Uehara, M. Quante, M. Seyda, J. Schuitenmaker, S. Tullius, A. Elkhal.
Surgery, Transplant Surgery Research Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
CD4+CD25+Foxp3+ regulatory T cells (Tregs) play a central role in the maintenance of immune tolerance and T cell homeostasis. It is known that Tregs promote…
2016 American Transplant Congress
Designing and Synthesizing a Novel Highly Selective Immunoproteasome Inhibitor That Promotes Long Term Heart Allograft Acceptance While Reducing Plasma Cells and Donor Specific Antibodies.
A. Mihali,¹ E. Sula Karreci,¹ A. Kurdi,³ L. Riella,¹ Y. Kawano,³ H. Fan,² P. Singh,² I. Ghobrial,³ C. Nathan,² G. Lin,² J. Azzi.¹
¹Transplantation Research Center, Harvard Medical School, Boston; ²Department of Microbiology and Immunology, Weill Cornell Medicine, NY; ³Department of Medical Oncology, Dana-Farber Cancer Institute, Boston.
Antibody mediated rejection (AMR) is one of the most important barriers to improving long-term transplant outcomes. Traditional therapies for AMR do not deplete the source…
2016 American Transplant Congress
NK-Activating MCMV Strain Is Associated with Increased Murine Renal Transplant Injury.
M. Shimamura,¹ M. Li,² B. Chen,² J. George,² T. Schoeb.³
¹Vaccines and Immunity, Pediatric Infectious Diseases, Nationwide Children's Hospital, The Ohio State University, Columbus, OH; ²Pediatric Infectious Diseases, Cardiothoracic Surgery, Nephrology, University of Alabama at Birmingham, Birmingham, AL; ³Pathology and Genetics, University of Alabama at Birmingham, Birmingham, AL.
Background: CMV contributes to inferior longterm kidney transplant survival. In a murine model, NK cells infiltrate MCMV infected renal allografts in greater numbers than in…
2016 American Transplant Congress
Type-I Interferon Induced Cross-Competition of IL-10 Signaling and Its Role in the Abrogation of Transplant Tolerance.
M. Iglesias, A. Arun, W. Lee, G. Brandacher, G. Raimondi.
Plastic Surgery, Johns Hopkins University, School of Medicine, Baltimore, MD.
PurposeA growing body of evidence shows that induction of long term transplant survival by “costimulation blockade” (CoB) regimens is impaired by inflammatory responses. In particular,…
2016 American Transplant Congress
Pediatric Access to Kidney Transplantation Under KAS.
W. Cherikh,¹ D. Stewart,¹ A. Kucheryavaya,¹ M. Aeder,² E. Brewer.³
¹UNOS, Richmond, VA; ²Univ. Hosp. Case Med Ctr, Cleveland, OH; ³Texas Children's Hosp/Baylor College Medicine, Houston, TX.
Background. Under the kidney allocation system (KAS) implemented on Dec 4, 2014, pediatric (ped) priority is now based on Kidney Donor Profile Index (KDPI) <35%…
2016 American Transplant Congress
Who Should Decide? Potential Living Kidney Donor Preferences for Making Decisions About Risk.
C. Thiessen,¹ J. Gannon,¹ K. Kennedy,² D. Dobosz,¹ S. Li,¹ D. Gray,³ A. Mussell,³ E. Gordon,² P. Reese,³ S. Kulkarni.¹
¹Yale U, New Haven; ²Northwestern U, Chicago; ³U Pennyslvania, Philadelphia.
BackgroundTransplant centers debate how to manage risks to potential living kidney donors (LKDs) when there is a lack of consensus about reasonable donor risk .We…