ATC Abstracts

American Transplant Congress abstracts

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  • 2016 American Transplant Congress

    Associations Between Deceased-Donor Urine MCP-1 and Kidney Transplant Outcomes.

    S. Mansour,1 J. Puthumana,1 P. Reese,2 I. Hall,1 M. Doshi,3 F. Weng,4 B. Schröppel,5 H. Thiessen-Philbrook,1,6 M. Bimali,1 C. Parikh.1

    1Nephrology, Yale University School of Medicine, New Haven, CT; 2Renal-Electrolyte and Hypertension, University of Pennsylvania, Philadelphia, PA; 3Wayne State University, Detroit, MI; 4Saint Barnabas Medical Center, Livingston, NJ; 5Nephrology, University Hospital, Ulm, Germany; 6Nephrology, Western University, London, ON, Canada.

    Current assessments of deceased donor kidneys lack precision in predicting recipient graft function. Mouse models have demonstrated that monocyte chemoattractant protein-1 (MCP-1) has a pivotal…
  • 2016 American Transplant Congress

    Does Post-Transplant Adherence Come at a Cost?

    K. Yadav, T. Nevins, D. Vock, W. Thomas, W. Robiner, A. Matas.

    University of Minnesota, Minneapolis, MN.

    Background: It is well documented that organ transplant (tx)recipients have an increased incidence of cancer including virus associated cancers like lymphoma. Our objective was to…
  • 2016 American Transplant Congress

    Clinical and Subclinical Cardiac Events After Kidney Transplantation (KTX).

    F. Cosio,1 H. Amer,1 M. Keddis,2 A. Jaffe.3

    1Transplant Center, Mayo Clinic, Rochester, MN; 2Nephrology, Mayo Clinic, Phoenix, AZ; 3Lab Medicine/Pathology, Mayo Clinic, Rochester, MN.

    Introduction. Elevated levels of the biomarker cardiac troponin T levels (cTNT) pre- KTX relates to high mortality and CV risk pre and post-KTX. We sought…
  • 2016 American Transplant Congress

    HLA Identical or Haploidentical Combined Kidney and Bone Marrow Transplantation for Multiple Myeloma with End-Stage Renal Failure.

    T. Kawai,1 Y.-B. Chen,1 M. Sykes,2 C. Benedict,1 N. Tolkoff-Rubin,1 B. Day,1 S. McAfee,1 K. Ballen, S. David,1 T. Spitzer.1

    1Massachusetts General Hospital, Boston; 2Columbia University, New York.

    Patients with multiple myeloma (MM) who developed end-stage renal disease (ESRD) are generally not eligible for either kidney transplantation or allogeneic stem-cell transplant. We performed…
  • 2016 American Transplant Congress

    Impact of Early Allograft Dysfunction (EAD) and Its Components on Patient Survival Following Liver Transplantation (LT): Long-Term Outcomes Up to 10 Years.

    B. Ekser, R. Mangus, J. Fridell, C. Kubal, J. Davis, J. Salisbury, T. Salisbury, S. Nagaraju, P. Mihaylov, A. Tector.

    Transplant Division, Department of Surgery, Indiana University, Indianapolis, IN.

    Background: It has been shown that EAD in LT is a useful tool to predict intermediate (5-year) mortality. The purpose of this study is to…
  • 2016 American Transplant Congress

    Comparison of Three Approaches for Laparoscopic Donor Nephrectomy: Transvaginal, Transumbilical Single Site and Retroperitoneal.

    M. Miura, H. Higashiyama.

    Department of Urology and Renal Transplantation Surgery, Sapporo Hokuyu Hospital, Sapporo, Japan.

    Objectives: Reduction of burdens to live kidney donors are important. The aim of this study was to compare the surgical outcomes of 3 approaches we…
  • 2016 American Transplant Congress

    Absence of Receptors for C3a or C5a Prevent Alloreactive CD8 T Effector Cell (Teff) Expansion but Differentially Impact Memory (Tmem) Persistence Posttransplantation.

    D. Mathern, P. Heeger.

    Translational Transplant Research Center, Dept of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.

    As Tmem are known barriers to transplant survival and tolerance in animals and human transplant recipients, understanding factors that drive the formation and survival of…
  • 2016 American Transplant Congress

    The Impact of Complement Binding Donor Specific Antibodies in the First Year After Heart Transplantation.

    J. Patel, M. Kittleson, D. Chang, T. Aintablian, A. Velleca, D. Ramzy, L. Czer, J. Kobashigawa.

    Cedars-Sinai Heart Institute, Los Angeles, CA.

    Background: The development of donor specific antibodies (DSA) after heart transplant has been associated with poor outcome. We now have the ability to assess the…
  • 2016 American Transplant Congress

    Human and Mouse Treg Use Lymphotoxin for Migration Across Lymphatic Endothelium.

    C. Brinkman,1 K. Hippen,2 B. Blazar,2 J. Bromberg.1

    1University of Maryland, Baltimore, MD; 2Univerity of Minnesota, Minneapolis, MN.

    Introduction: Lymphotoxin (LT) directs lymphoid organ structure, and LTβ receptor (LTβR) is involved in leukocyte migration into lymph nodes (LN) and thymocyte migration. We previously…
  • 2016 American Transplant Congress

    Allo-Specific Memory B Cell Recall Responses Are Dependent on B Cell Autophagy.

    J. Leventhal,1 M. Fribourg,2 J. Ni,1 P. Heeger.1

    1Medicine, Icahn School of Medicine at Mount Sinai, NY, NY; 2Neurology, Icahn School of Medicine at Mount Sinai, NY, NY.

    B cells, and in particular, memory B cells (Bmem) are sources of donor specific antibodies (DSA) that cause allograft injury. Understanding requirements for Bmem function/survival…
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