2016 American Transplant Congress
Traditionally Unacceptable Organs Promote Liver Transplantation in Patients with Long Waiting Times in the Share 35 Era.
Hepatocellular carcinoma (HCC) remains the most commonly granted MELD exception (M/E). Share 35 has disadvantaged this population. We have developed a strategy to use traditionally…2016 American Transplant Congress
Survival Benefit of Living Donor ABOi Kidney Transplantation.
A recent editorial in AJT characterized ABOi transplants as "Twice as Expensive, Half as Good" and challenged the ABOi community to evaluate survival benefit of…2016 American Transplant Congress
Relative Distribution of Livers from HCV+ Donors in the U.S.
1University of California, San Francisco, San Francisco; 2Loma Linda University, Loma Linda.
Background: HCV-antibody positive donors represent an effective strategy to increase liver availability to HCV+ recipients. However, many HCV+ liver transplant (LT) candidates are now receiving…2016 American Transplant Congress
Evaluation of a Novel Global Immunity Assay to Predict Infections in Organ Transplant Recipients.
Multi-Organ Transplant, University Health Network, Toronto, Canada.
BackgroundSimple standardized measures of global immunity may help predict the risk of infections post-transplant. The Quantiferon-Monitor (QFM) test is a novel interferon-γ (IFN-γ) release assay…2016 American Transplant Congress
An Interventional Study Evaluating Cell Mediated Immunity to Guide Therapy for CMV Viremia.
Multi-Organ Transplant, University Health Network, Toronto, ON, Canada.
BackgroundPatients treated for CMV viremia commonly relapse after discontinuation of therapy. CMV-specific CD8+ T-cell mediated immunity (CMI) is useful to predict the risk of CMV…2016 American Transplant Congress
Obliterative Bronchiolitis Following Lung Transplantation Is Preceded by Depletion of Airway Submucosal Glands and Basal Stem Cells.
University of Iowa, Iowa City, IA.
Background: Obliterative bronchiolitis (OB), a major cause of morbidity and mortality following lung transplantation, is characterized by progressive fibrosis of distal airways. We hypothesized that…2016 American Transplant Congress
Donation After Cardiac Death Dose Not Impact Short and Long Term Graft Outcomes in Simultaneous Pancreas and Kidney Transplantation.
1Washington University in St. Louis, St. Louis; 2Saint Louis University, St. Louis.
Background:Organ donation after cardiac death (DCD) has the potential to expand the pool of available organs for transplantation. Because of the concern that warm ischemia…2016 American Transplant Congress
Fate of Endogenous Alloreactive B Cells in Transplant Tolerance.
The conceptual underpinning of our studies is that robust tolerance requires multiple mechanisms to enforce functional quiescence of alloreactive T and B cells. While much…2016 American Transplant Congress
Sphingosine 1-Phosphate (S1P) Receptors Differentially Regulate Murine and Human CD4 T Cell Migration Across Lymphatic Endothelium.
1University of Maryland, Baltimore; 2University of Minnesota, Minneapolis.
S1P and S1PR1 are used by T cells to migrate from thymus across microvascular endothelium to the blood circulation, and across medullary lymphatic endothelium of…2016 American Transplant Congress
Impact of Low Dose Tacrolimus with Everolimus Regimen on Renal Pathology and T-Regulatory Cells in Kidney Transplant.
Calcineurin inhibitors (CNI) serve as the cornerstone of immunosuppression (IS) after kidney transplant. However chronic CNI nephrotoxicity has been implicated in allograft dysfunction. We hypothesize…
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