Am J Transplant, Volume 16, Suppl 3 Archives - Page 137 of 180 - ATC Abstracts

2016 American Transplant Congress
Gene Expression Microarray Analysis of Purified CD16-Stimulated Human NK Cells and Indication Biopsies Supports a CD16-Mediated Role for NK Cells in Antibody-Mediated Kidney Rejection.
M. Parkes,¹ P. Halloran,¹ L. Hidalgo.²
¹Dept. of Medicine, University of Alberta, Edmonton, AB, Canada; ²Dept. of Laboratory Medicine & Pathology, University of Alberta, Edmonton, AB, Canada.
BACKGROUND: CD16α mediates NK cell responses to donor-specific IgG antibodies (DSA), and shares mechanisms with effector T cell receptor (TCR) stimulation. Whether CD16α-inducible transcripts are…
2016 American Transplant Congress
Utilizing HLA Single Antigen Flow Beads Assays to Evaluate Anti-MAMU Antibody in Sensitized Nonhuman Primate Model.
J. Kwun,¹ C. Burghuber,² M. Manook,¹ A. Clark,³ D. Chen,³ S. Knechtle.¹
¹Surgery, Duke University, Durham; ²Surgery, Medical University of Vienna, Vienna, Austria; ³Pathology, Duke University, Durham.
[Background] Non-human primate models of sensitization provide great preclinical models to investigate the mechanisms of antibody-mediated rejection or desensitization. Now there a growing interest on…
2016 American Transplant Congress
Ex Vivo Expansion of Human Alloantigen-Reactive Regulatory T Cells Using Monocyte-Derived Dendritic Cells versus CD40L-Stimulated B Cells.
H. Zhang,¹ Y. Zhao,¹ L. Lu,¹ Q. Tang,² M. Ezzelarab,¹ A. Thomson.¹
¹Thomas E. Starzl Transplantation Institute Department of Surgery, University of Pittsburgh school of medicine, Pittsburgh, PA; ²Department of Surgery, UCSF, San Francisco, CA.
Background:Alloantigen-reactive murine and human CD4+CD25+FOXP3+ regulatory T cells (arTreg) are more potent in promoting long-term allograft survival than polyclonal Treg in experimental models. Dendritic cells…
2016 American Transplant Congress
Center Volume Is Associated with Outcome Following Pancreas Transplantation within the Eurotransplant Region.
W. Kopp,^1,2 M. van Meel,² H. Putter,³ U. Samuel,² H. Arbogast,⁴ W. Schareck,⁵ J. Ringers,¹ A. Braat.¹
¹Surgery, Leiden University Medical Center, Leiden, Netherlands; ²Eurotransplant International Foundation, Leiden, Netherlands; ³Medical Statistics, Leiden University Medical Center, Leiden, Netherlands; ⁴General, Visceral, Transplant, Vascular and Thoracic Surgery, University of Munich – Grosshadern Medical Centre, Munich, Germany; ⁵University Medical Center Rostock, Rostock, Germany.
Introduction Outcome following all kinds of surgery depends on several factors, amongst these the annual volume-outcome relationship. This might also be the case in a…
2016 American Transplant Congress
Plasma Alemtuzumab Levels Show Great Interpatient Variability, but Are Not Associated with Late Acute Rejection in Simultaneous Pancreas-Kidney Recipients.
J. Bank,¹ M. Mallat,¹ C. Jol-van der Zijde,² R. Bredius,² P. van der Boog,¹ A. Braat,³ J. Ringers,³ M. Reinders,¹ J. de Fijter.¹
¹Nephrology, LUMC, Leiden, Netherlands; ²Pediatrics, LUMC, Leiden, Netherlands; ³Surgery, LUMC, Leiden, Netherlands.
Introduction: Alemtuzumab induction followed by a steroid-free, tacrolimus (Tac) and mycophenolate mofetil (MMF) based regimen effectively prevented acute rejection after simultaneous pancreas-kidney transplantation (SPKT). Acute…
2016 American Transplant Congress
Comparison of Outcomes from Patients with Completion versus Total Pancreatectomy with Islet Autotransplantation: A Single-Institution Experience with 120 Consecutive Cases.
G. Yoshimatsu,¹ M. Takita,¹ R. Shahbazov,² M. Lawrence,¹ B. Naziruddin,³ P. Kim,³ M. Levy,⁴ N. Onaca.³
¹Islet Cell Laboratory, Baylor Research Institute, Dallas, TX; ²Department of Surgery, University of Virginia, Charlottesville, VA; ³Transplant Division, VCU Medical Center, Richmond, VA; ⁴Baylor Simmons Transplant Institute, Dallas, TX.
Introduction: Total pancreatectomy (TP) or completion pancreatectomy is considered to effectively eliminate the severe pain from refractory chronic pancreatitis, if prior procedures failed. Islet autotransplantation…
2016 American Transplant Congress
Membrane Proteome Profiling Reveals Molecular Changes Associated with Donor-Specific Tolerance to Vascularized Composite Allotransplants.
H.-Y. Cheng,¹ C.-L. Han,² F.-W. Jiang,² L.-Y. Shih,¹ C.-F. Lin,¹ Y.-J. Chen,³ F.-C. Wei.^1,4
¹Center for Vascularized Composite Allotransplantation, Chang Gung Memorial Hospital, Gueishan, Taoyuan, Taiwan; ²Master Program for Pharmacogenomics and Pharmacoproteomics, Taipei Medical University, Taipei, Taiwan; ³Institute of Chemistry, Academia Sinica, Taipei, Taiwan; ⁴College of Medicine, Chang Gung University, Gueishan, Taoyuan, Taiwan.
Background: although donor-specific tolerance to vascularized composite allotransplants (VCAs) has been successfully induced with different regimes, molecular changes associated with tolerance are not well understood.Materials…
2016 American Transplant Congress
Successful Transplantation in ABO- and HLA-Incompatible Kidney-Transplant Patients.
L. Rostaing, N. Congy, A. Allal, L. Esposito, F. Sallusto, N. Congy, X. Doumerc, B. Debiol, N. Kamar.
Néphrologie et Transplantation d'Organes, CHU Rangueil, Toulouse, France; INSERM U 563, CHU Purpan, Toulouse, France; Faculté de Médecine de Rangueil, Université Toulouse III Paul Sabatier, Toulouse, France; INSERM U1043 CNRS UMR 5282, CHU Purpan, Toulouse, France.
Introduction: ABO-incompatible (ABOi) and HLA-incompatible (HLAi) kidney transplantation using living donors is common place; however, few data have reported on the outcomes of ABOi/HLAi living-kidney…
2016 American Transplant Congress
Young, Caucasian, Better Educated and Less Socially Deprived Patients Are More Likely to Be Transplanted with a Living Donor Kidney in the UK.
D. Wu,¹ M. Robb,² C. Watson,³ R. Ravanan,⁴ J. Forsythe,¹ W. Metcalfe,¹ C. Dudley,⁴ C. Bradley,⁵ H. Draper,⁶ A. Bradley,³ G. Oniscu.¹
¹Royal Infirmary of Edinburgh, Edinburgh, United Kingdom; ²NHSBT, Bristol, United Kingdom; ³University of Cambridge, Cambridge, United Kingdom; ⁴Southmead Hospital, Bristol, United Kingdom; ⁵University of London, London, United Kingdom; ⁶University of Birmingham, Birmingham, United Kingdom.
IntroductionLiving donor kidney transplantation (LDKT) has significant benefits over deceased donor kidney transplantation (DDKT) in terms of improved survival and timely access to transplant. There…
2016 American Transplant Congress
A Quantitative CD45 Immunohistochemical Assay Allows Precise and Reproducible Measurement of Inflammation in Renal Transplant Biopsies.
V. Walavalkar,¹ S. Bowman,¹ L. Laszik,¹ D. Ikle,² S. Chandran,¹ F. Vincenti,¹ Z. Laszik.¹
¹UCSF, San Francisco, CA; ²Rho, Chapel Hill, NC.
Purpose: Total inflammation (TI) is an important variable for the pathologic work-up of transplant kidney biopsies (TxBx) in the Banff schema. However, current standard pathologic…