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American Transplant Congress abstracts

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  • 2016 American Transplant Congress

    Late Renal Xenograft Failure Is Antibody-Mediated: Description of the Longest-Reported Survival in Pig-to-Primate Renal Xenotransplantation.

    L. Higginbotham,1 S. Kim,1 D. Mathews,1 A. Stephenson,1 C. Breeden,1 C. Larsen,1 M. Ford,1 K. Newell,1 A. Tector,2 A. Adams.1

    1Emory Transplant Center, Emory University Hospital, Atlanta, GA; 2Indiana University School of Medicine, Indianapolis, IN.

    Introduction. Xenotransplantation has the potential to alleviate the organ supply shortage, yet pig-to-primate renal xenotransplant has met limited success due to natural preformed anti-pig antibody.…
  • 2016 American Transplant Congress

    Autologous BK-Specific T-Cell Lines in Kidney Transplant Recipients.

    C. Lamarche,1,2,3 O. Julie,1,3 C. Carli,1,3 J.-S. Delisle.1,2,3

    1Centre de Recherche de l'Hôpital Maisonneuve-Rosemont, Montreal, QC, Canada; 2Canadian National Transplant Research Program (CNTRP), Edmonton, Canada; 3ThéCell Network, Quebec, Canada.

    Background: More than 75% of the population has been exposed to BK polyomavirus and carries latent virus in the uroepithelium. Immunocompetent hosts are asymptomatic but…
  • 2016 American Transplant Congress

    Calcineurin Inhibitors Promote Metastasis in Post-Transplant Colorectal Cancer Through Cancer Related- Exosomes Released from Cancer Cells in TGF Beta Independent Epitheilal to Mesenquimal Transition.

    V. Tubita,1 J. Segui-Barber,4 M.-J. Ramírez-Bajo,1 D. Moya-Rull,1 P. Piselli,3 D. Verdirosi,3 F. Oppenheimer,1,2,5 D. Serraino,6 H. Del Portillo,4,7 F. Diekmann,1,2,5 J. Campistol,1,2,5 I. Revuelta.1,2,5

    1Experimental Laboratory of Nephrology and Kidney Transplant, IDIBAPS, Barcelona, Spain; 2Department of Nephrology and Kidney Transplant, Hospital Clínic, Barcelona, Spain; 3Dipartamento di Epidemiologia e Ricerca Pre-Clinica, INMI “L. Spallanzani” IRCCC, Rome, Italy; 4ISGlobal, CRESIB, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain; 5National Network for Kidney Research (REDinREN), Carlos III Royal Institute, Ministry of Health, Madrid, Spain; 6IRCCS Centro di Riferimento Oncologico, Aviano, Italy; 7Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.

    Introduction: Cancer is one of the major causes of death in kidney transplantation. Despite more mortality in colon cancer (CRC), similar incidence than general population…
  • 2016 American Transplant Congress

    Pancreatic Allograft Failure in Latino Recipients: Diabetes Mellitus Type 2 Conversion?

    H. Fernandez, G. McKenna, N. Onaca, R. Ruiz.

    Baylor University Medical Center, Dallas, TX.

    Introduction:Pancreas transplantation is the definitive treatment for diabetes mellitus (DM). The advantages of simultaneous kidney pancreas transplant in Latinos have been demonstrated previously, but there…
  • 2016 American Transplant Congress

    An Analysis of Factors Associated with Pancreas Allograft Thrombosis.

    J. Steggerda, K. Bornhurst, A. Annamalai, A. Peng, J. Mirocha, D. Dafoe.

    Surgery, Cedars-Sinai Medical Center, Los Angeles, CA.

    A successful simultaneous pancreas-kidney (SPK) transplant in recipients with end-stage diabetic nephropathy will provide normoglycemia and exert a salutary effect on neurovascular complications. Early, non-technical…
  • 2016 American Transplant Congress

    Planning Genitourinary Vascularized Composite Allotransplantation: A Pre-Operative Imaging Protocol.

    I. Schol, T. Drijkoningen, G. Choy, R. Liu, C. Tanrikut, P. Holzer, D. Ko, C. Cetrulo.

    Massachusetts General Hospital, Boston, MA.

    Study purpose: To define the ideal pre-operative imaging protocol necessary for proper planning of a genitourinary vascularised composite allotransplantation (GUVCA) procedure.Methods: The multidisciplinary GUVCA team…
  • 2016 American Transplant Congress

    Everolimus Decline Anti-ABO Blood Type Antibody Titer in Desensitization for ABO Incompatible Kidney Transplantation.

    Y. Wada, N. Fukuzawa, H. Harada.

    Kidney Transplantation Surgery, Sapporo City General Hospital, Sapporo, Hokkaido, Japan.

    INTRODUCTION: The immoderate donor shortage and sophisticated desensitization protocols resulted in the explosive increase and great success of the ABO blood type incompatible kidney transplantation…
  • 2016 American Transplant Congress

    Age-Based High GFR Associates with Clinical Risk Among Potential Living Donors, but Only with Increased Nephron Number Among Approved Donors.

    H. Chakkera,1 E. Poggio,3 A. Denic,2 J. Mathew,2 W. Kremers,2 J. Larson,2 H. Amer,2 F. Cosio,2 M. Stegall,2 S. Taler,2 A. Rule.2

    1Mayo Clinic, Arizona; 2Mayo Clinic, Rochester; 3Cleveland Clinic, OH.

    Background:Association of high GFR with clinical and kidney structural characteristics among living donors has not been studied.Methods: Study cohort:potential kidney donors evaluated at Mayo Clinic…
  • 2016 American Transplant Congress

    Landscape of Hypertension Treatment in Former Kidney Donors.

    L. Ferrara, O. Sanchez, D. Berglund, A. Matas, H. Ibrahim.

    U of MN, Mpls.

    The aim of this analysis is to describe the general epidemiological features for the development of hypertension and the most frequent medical therapies prescribed in…
  • 2016 American Transplant Congress

    Surveillance Biopsy Findings with Alemtuzumab (ALZ) Induction in Kidney Transplantation.

    H. Madariaga,1 R. Ugarte,1 C. Drachenberg,2 N. Costa,1 B. Thomas,1 J. Bromberg,3 M. Weir,1 A. Haririan.1

    1Department of Medicine, University of Maryland Medical Center, Baltimore, MD; 2Department of Pathology, University of Maryland Medical Center, Baltimore, MD; 3Department of Surgery, University of Maryland Medical Center, Baltimore, MD.

    The risk of subclinical histological changes in renal allografts with ALZ induction is not well defined. Hence, we performed a retrospective analysis of 527 surveillance…
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