Am J Transplant, Volume 16, Suppl 3 Archives - Page 13 of 180 - ATC Abstracts

2016 American Transplant Congress
Informing Informed Consent for High KDPI Kidneys.
A. Nishio Lucar, D. Keith, G. Vranic.
Medicine, University of Virginia, Charlottesville, VA.
The standard approach to informed consent for high KDPI (KDPI 86-100%) deceased donor kidneys (DDK) relies on anticipated graft half-life and may not provide candidates…
2016 American Transplant Congress
Pulmonary Hypertension in Renal Transplant Candidates: A Systematic Review and Meta-Analysis of the Available Evidence.
A. Moza,¹ A. Khan,² R. Prashar,³ S. Khan,¹ S. Khouri,¹ S. Vetteth,¹ D. Malhotra,¹ M. Rees,¹ G. Moukarbel,¹ J. Ortiz.¹
¹Cardiovascular Medicine, University of Toledo Medical Center, Toledo, OH; ²Cardiovascular Medicine, University of Louisville, Louisville, KY; ³Nephrology and Transplantation, Henry Ford Medical Center, Detroit, MI.
Background: Pulmonary hypertension (PHT) is common in patients with end stage renal disease (ESRD). Moderate to severe PHT is a strong independent predictor of mortality…
2016 American Transplant Congress
Local Infusion of MyD88 Inhibitor Inhibits Ischemia-Reperfusion Kidney Injury.
H. Cho,^1,3 J. Lee,^1,4 H. Kim,^1,2 Y. Han,² B. Kwon,^1,2 S. Park,^1,3 K. Park.⁴
¹Biomedical Research Center, Ulsan University Hospital, School of Medicine, University of Ulsan, Ulsan, Republic of Korea; ²School of Biological Sciences, University of Ulsan, Ulsan, Republic of Korea; ³Department of Surgery, Ulsan University Hospital, School of Medicine, University of Ulsan, Ulsan, Republic of Korea; ⁴Department of Internal Medicine, Ulsan University Hospital, School of Medicine, University of Ulsan, Ulsan, Republic of Korea.
We have previously shown that tubular epithelial cells play a central role in regulating ischemia-reperfusion kidney injury (K-IRI). Tubular epithelial cells damaged by hypoxic insult…
2016 American Transplant Congress
Recall Alloantibody Production Is Driven by CD138⁺ Cells Proliferating in the Spleens: An Indication for Long-Lived Plasma Cell Activities and Potential Therapeutic Target.
I. Kim, N.-N. Chai, A. Klein, S. Jordan, G. Wu.
Comprehensive Transplantation Center/Surgery, Cedars-Sinai Medical Center, Los Angeles, CA.
Background Donor-specific antibodies (DSA) generated in recall responses are produced by long-lived plasma cells (L-PC) residing in the bone marrows (BM). Mechanisms of L-PC activation,…
2016 American Transplant Congress
The Property of Modulatory T Cells Generated by Mixed Lymphocyte Culture with CD154 Blockade.
K. Hotta, T. Oura, B. Cosimi, T. Kawai.
Center for Transplantation Science, Massachusetts General Hospital, Boston, MA.
Background:Regulatory T cell (Treg) immunotherapy has been applied to minimize the immunosuppressive drugs in clinical transplantation. To avoid contamination of CD4+CD25- T cells, only highly…
2016 American Transplant Congress
Eliminating Xenoantigen Expression on Swine Red Blood Cells.
Z.-Y. Wang,¹ G. Martens,¹ R. Blankenship,¹ R. Sidner,¹ P. Li,¹ J. Estrada,¹ M. Tector,² A. Tector.^1,3
¹Surgery, Indiana University School of Medicine, Indianapolis, IN; ²Surgery, Indiana University Health, Indianapolis, IN; ³Indiana University Health Transplant Institute, Indianapolis, IN.
Background:The rapidly improving tools of genetic engineering may make it possible to overcome humoral immune barrier that prevents xenotransplantation. We hypothesize that levels of human…
2016 American Transplant Congress
Effect on Endothelial function when Hyperglycemia Is Reversed by Single Pancreas Transplantation.
T. Halden,^1,2 I. Eide,^1,2 D. Dahle,¹ A. Åsberg,^1,3 A. Reisæter,¹ T. Jenssen,^1,4 A. Hartmann.^1,2
¹Department of Transplant Medicine, Section of Nephrology, Oslo University Hospital, Rikshospitalet, Oslo, Norway; ²Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; ³Department of Pharmaceutical Biosciences, School of Pharmacy, University of Oslo, Oslo, Norway; ⁴Metabolic and Renal Research Group, UiT, The Arctic University of Norway, Tromsø, Norway.
Background: Endothelial dysfunction is a predictor for future cardiovascular disease. We have previously published that endothelial function improves in renal transplant recipients with post-transplantation diabetes…
2016 American Transplant Congress
What Is the Decline Rate of Pancreata Attributed to Donation After Cardiac Death When the Accompanied Kidney Is Transplanted?
T. Alhamad,¹ K. Lentine,² A. Taha,² J. Wellen,¹ D. Brennan.¹
¹Washington University in St. Louis, St. Louis; ²Saint Louis University, St. Louis.
Background:Pancreas transplantation in the U.S. has declined steadily in the U.S. over the past decade despite international growth of the practice. Reasons for this decline…
2016 American Transplant Congress
Assessing the Induction of Tolerance to Vascularized Composite Allotransplantation in Miniature Swine.
J. Walch, J. Alonso-Escalante, H. Wang, B. Oh, M. Iglesias, A. Lee, G. Brandacher, G. Raimondi.
Plastic and Reconstructive Surgery, Johns Hopkins Medical Institute, Baltimore, MD.
Purpose: Miniature swine is a pre-clinical large animal model well suited to validate protocols of tolerance induction to vascularized composite allotransplantation (VCA). However, tools to…
2016 American Transplant Congress
ABO-Incompatible Living Kidney Transplantation at Multicenter Japanese Case Series: Evolution of Outcomes and Immunosuppressive Management.
K. Tanabe,¹ M. Okumi,¹ M. Furusawa,¹ K. Unagami,¹ T. Hirai,¹ H. Shirakawa,² T. Shimizu,¹ K. Omoto,³ M. Inui,¹ H. Ishida.¹
¹Urology, Tokyo Women's Medical University, Tokyo, Japan; ²Urology, Ohkubo Hospital, Tokyo, Japan; ³Urology, Todachuo General Hospital, Saitama, Japan.
[lsaquo]Background[rsaquo]ABO-incompatible living kidney transplantation (ABO-ILKT) has been performed to broaden the range of donor types used for living related kidney transplantation (LKT). Recently, ABO-ILKT has…