Am J Transplant, Volume 16, Suppl 3 Archives - Page 12 of 180 - ATC Abstracts

2016 American Transplant Congress
Deceased Organ Donor Management: Does Hospital Volume Matter?
M. Patel,¹ J. Mohebali,¹ M. Sally,² T. Groat,² P. Vagefi,¹ D. Chang,¹ D. Malinoski.²
¹Massachusetts General Hospital, Boston; ²Portland Veterans Affairs Medical Center and Oregon Health & Science University, Portland.
Purpose: Despite the association between hospital volume and outcomes for various diseases, there have been no studies to assess the impact of hospital organ donor…
2016 American Transplant Congress
Viral Gastroenteritis in Adult and Pediatric Solid Organ Transplant (SOT) Patients.
C. Hernández Garcia,¹ B. Lee,¹ X. Pang,² H. Yuan Zhou,¹ J. Preikisatis.¹
¹Medicine, University of Alberta, Edmonton, AB, Canada; ²Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada.
BACKGROUND. Diarrhea in SOT recipients is common and often attributed to immunosuppressive drug side effects. However, enteric viruses are important causes of acute gastroenteritis and…
2016 American Transplant Congress
The Quilty Effect in Pediatric Heart Transplant Recipients.
A. Joong,¹ M. Richmond,¹ K. Stack,² R. Rodriguez,¹ J. McAllister,² W. Zuckerman,¹ T. Lee,¹ S. Law,¹ L. Addonizio.¹
¹Pediatric Cardiology, Columbia University, New York, NY; ²Surgery, Columbia University, New York, NY.
Purpose: The Quilty effect is defined as the presence of a nodular endocardial infiltrate of lymphocytes in an endomyocardial biopsy (EMB), and has been described…
2016 American Transplant Congress
IL-2 Therapy Restores the Impaired Function of Regulatory T Cells Induced by Calcineurin Inhibitors in Liver Transplantation.
G. Whitehouse, E. Gray, S. Mastoridis, E. Kodela, A. Sanchez-Fueyo, M. Martinez-Llordella.
Liver Science Department, King's College London, London, United Kingdom.
CD4+CD25+FOXP3+ regulatory T cells (Tregs) have an essential role in immune regulation and constitute a key target for cellular immunotherapies in transplantation. IL-2 is critical…
2016 American Transplant Congress
Long-Lasting Skin Allograft Tolerance Induced and Maintained by Short-Term Vascularized Bone Marrow Transplant in a Mouse Model.
C.-H. Lin,¹ M. Anggelia,¹ H.-Y. Cheng,¹ Y.-L. Wang,¹ W.-Y. Chuang,¹ C.-H. Lin,¹ G. Brandacher.²
¹Center for Vascularized Composite Allotransplantation, Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan; ²Department of Plastic and Reconstructive Surgery, Vascularized Composite Allotransplantation (VCA) Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD.
Background: Accumulating evidences indicate that vascularized bone marrow transplantation (VBMT) plays a critical role in inducing tolerance of vascularized composite allografts (VCA). Recipients with long-term…
2016 American Transplant Congress
Targeting IFN-g-Expressing TIM-4⁺B Effector (Beff) Cells as a Novel Strategy to Prevent Allograft Rejection.
Q. Ding,¹ K. Mohib,¹ S. Xiao,² V. Kuchroo,² D. Rothstein.¹
¹University of Pittsburgh, Pittsburgh; ²Harvard Medical School, Boston.
B cell depletion can augment or inhibit auto- and allo- immune responses in humans and mice without altering Ig levels. This is likely due to…
2016 American Transplant Congress
Mechanistic Insights into How Targeting of HDAC10 Promotes Foxp3+ Treg Cell Suppressive Activity, Gene Expression and Metabolism, and Enhances Allograft Survival.
S. Dahiya,¹ L. Wang,¹ U. Beier,^1,2 A. Angelin,¹ R. Han,¹ D. Wallace,^1,2 W. Hancock.^1,2
¹Children's Hospital of Philadelphia, Philadelphia; ²University of Pennsylvania, Philadelphia.
Foxp3+ T-regulatory (Treg) cells are key regulators of immune responses that can result in unwarranted inflammation and promote allograft rejection. From a theoretical perspective, targeting…
2016 American Transplant Congress
Characteristics and Outcomes of Vancomycin Resistant Enterococcus Bacteremia After Liver Transplant.
R. Odrobina,¹ C. Kovacs,¹ R. Butler,² C. Koval.¹
¹Department of Infectious Diseases, Cleveland Clinic, Cleveland, OH; ²Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH.
Vancomycin Resistant Enterococcus (VRE) infection is reported in 5-20% of liver transplant (LT) recipients and is associated with decreased survival. Published data includes infections of…
2016 American Transplant Congress
Biliary Epithelial Damage, Regenerative Capacity and Local Immune Response After Cold Storage of DBD Livers Determine Biliary Complications After Liver Transplantation.
S. Brunner, H. Junger, H. Schlitt, S. Fichtner-Feigl.
Department of Surgery, University Medical Center Regensburg, Regensburg, Germany.
Background: The aim of this study was to examine the development and molecular mechanisms of bile duct (BD) damage between organ retrieval and transplantation and…
2016 American Transplant Congress
Effect of mTOR Inhibitors on the Risk of Cancer Development After Kidney Transplantation in Chinese Population.
C.-C. Kao,¹ J.-S. Liu,² M.-H. Lin,² F.-C. Chang,¹ Y.-C. Lin,¹ H.-H. Chen,¹ T.-W. Chen,¹ C.-C. Hsu,² M.-S. Wu.¹
¹Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan; ²Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
Introduction The mTOR inhibitor is an immunosuppressive drug used in kidney transplantation. Whether the mTOR inhibitors is associated with reduced risk of cancer development in…