Am J Transplant, Volume 16, Suppl 3 Archives - Page 12 of 180 - ATC Abstracts

2016 American Transplant Congress
Diffuse Extent of Peritubular Capillaritis in Late Antibody Mediated Rejection Is Associated with More Severe Chronic Allograft Damage.
Z. Kikić,¹ F. Eskandary,¹ H. Herkner,² R. Oberbauer,¹ G. Bond,¹ H. Regele,³ G. Böhmig,¹ N. Kozakowski.³
¹Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria; ²Emergency Medicine, Medical University of Vienna, Vienna, Austria; ³Institute of Clinical Pathology, Medical University of Vienna, Vienna, Austria.
Peritubular capillaritis (ptc) is a widely accepted histologic criterion of antibody-mediated rejection (ABMR), and while the ptc score is incorporated in current diagnostic recommendations, the…
2016 American Transplant Congress
iNKT Cell Ligands Administered with Bone Marrow Cells Expand Allo-Specific Regulatory T Cells In Vivo and Establish Transplant Tolerance.
S. Miyairi,^1,2 T. Hirai,¹ M. Okumi,¹ Y. Ishii,³ K. Yamazaki,² K. Tanabe.¹
¹Urology, Tokyo Women's Medical University, Tokyo, Japan; ²Cardiovascular Surgery, Tokyo Women's Medical University, Tokyo, Japan; ³Vaccine Design, RIKEN IMS-RCAI, Yokohama, Japan.
Invariant natural killer T(iNKT) cells have the powerful potential to expand regulatory T cells(Tregs), especially when they are presented α-galactosylceramide(aGC) by B cells. We previously…
2016 American Transplant Congress
Citrate-Based Thermoresponsive Hydrogel as a Versatile Platform for Extrahepatic Islet Transplantation.
Y. Zhu,¹ X. Zhang,² A. Guillermo,¹ X. Luo.²
¹McCormick School of Engineering, Northwestern University, Chicago, IL; ²Comprehensive Transplant Center, Northwestern University, Chicago, IL.
Introduction: Islets transplantation in the liver often results in limited islets survival presumably due to abnormal blood flow dynamics and acute inflammatory response. The objective…
2016 American Transplant Congress
Resveratrol Attenuates Liver IRI by Regulating Macrophage Activation Through SIRT1/p19/p53 Pathway.
K. Nakamura,¹ M. Zhang,² B. Ke,¹ S. Kageyama,¹ R. Busuttil,¹ J. Araujo,² J. Kupiec-Weglinski.¹
¹Surgery, Liver Transplant, University of California-Los Angeles, Los Angeles, CA; ²Medicine, Division of Cardiology, University of California-Los Angeles, Los Angeles, CA.
Background/Aim: Sirtuin1 (SIRT1), a NAD+-dependent type III histone/protein deacetylase, plays a key role in inflammation responses and stress resistance. Although SIRT1 may regulate innate activation…
2016 American Transplant Congress
Establishment of SCID Pigs Cell Lines to Prevent Immunodeficiency Using RGEN System.
D.-H. Kim,¹ J.-S. Ahn,¹ S. Hwang,² J.-W. Lee.¹
¹Functional Genomics Reaserch Center, KRIBB, Daejeon, Korea; ²Animal Biotechnology Division, RDA, Wanju-gun, Jeollabuk-do, Korea.
Severe immune disorder is the biggest problem in xenotransplantation. To overcome the the problem, producing severe combined immune deficiency (SCID) pigs which lack T cell…
2016 American Transplant Congress
Shifts of Etiology in Patients with in Bacteremic Liver Transplant Recipients.
S. Kim,¹ Y. Kim,¹ J. Choi,¹ S. Yoon,¹ G. Na,² J. Kim,² I. Moon,² Y. Yoo,² D. Kim.²
¹Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; ²Department of Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
BackgroundBacteremias are the most frequently occurring infectious complications after liver transplantation. The spectrum of pathogens and patters of antibiotics susceptibility can vary owing to the…
2016 American Transplant Congress
A Decade of Donor-Derived Disease: A Report of the OPTN Ad Hoc Disease Transmission Advisory Committee (DTAC).
D. Kaul,¹ S. Tlusty,² A. Wilk,² C. Wolfe.¹
¹OPTN Ad Hoc Disease Transmission Advisory Committee, Richmond, VA; ²United Network for Organ Sharing, Richmond, VA.
Intro: The OPTN DTAC evaluates potential donor derived transmission events (PDDTE), including infections & malignancies, to assess for donor transmitted events.Methods: Reports of unexpected PDDTE…
2016 American Transplant Congress
Acute Rejection by Belatacept (Bela) Dosing Frequency: Results from a Phase II Study of Kidney Transplant Recipients.
F. Vincenti,¹ G. Blancho,² A. Durrbach,³ G. Grannas,⁴ J. Grinyó,⁵ U. Meier-Kriesche,⁶ M. Polinsky,⁶ H. Zhao,⁶ C. Larsen.⁷
¹UCSF, San Francisco, CA; ²University Hospital of Nantes, Nantes, France; ³University Hôpital of Bicêtre, Le Kremlin-Bicêtre, France; ⁴Medizinische Hochschule Hannover, Hannover, Germany; ⁵University Hospital of Bellvitge, Bellvitge, Spain; ⁶Bristol-Myers Squibb, Lawrenceville, NJ; ⁷Emory University Transplant Center, Atlanta, GA.
Background: At 1 year post transplant in IM103-100 (NCT00035555), bela-treated patients had similar acute rejection (AR) rates and significantly improved renal function vs cyclosporine A…
2016 American Transplant Congress
Incidence of Post-Transplant Malignancy (PTM) After Pediatric Kidney Transplantation (PKTx).
O. Serrano,¹ A. Bangdiwala,² D. Vock,² W. Payne,¹ T. Dunn,¹ S. Chinnakotla,¹ E. Finger,¹ R. Kandaswamy,¹ T. Pruett,¹ A. Matas,¹ B. Chavers.³
¹Surgery, Univ. of Minnesota, Minneapolis, MN; ²Biostatistics, Univ. of Minnesota, Minneapolis, MN; ³Pediatrics, Univ. of Minnesota, Minneapolis, MN.
PURPOSE: Post-transplant immunosuppression is associated with an increase in cancer rates. To date, the long-term incidence of PTM among PKTx recipients has not been well-characterized.METHODOLOGY:…
2016 American Transplant Congress
Barriers to Living Donor Kidney Transplant in the Pediatric Population.
S. Taormina,¹ M. Galloway,² A. Jain.³
¹Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI; ²Department of Psychiatry and Behavioral Neurosciences and Department of Anesthesiology, Wayne State University School of Medicine, Detroit, MI; ³Division of Pediatric Nephrology and Hypertension, Wayne State University School of Medicine, Detroit, MI.
Objective:A shift from living donor transplants to deceased donor transplants has been noted nationwide and is more prominent at some centers than others. Our objective…